Publications by authors named "Daniel Zamanillo"

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Generation and phenotypic characterization of a sigma-1 receptor knockout rat.
Miguel Á Huerta, Xavier Codony, M Carmen Ruiz-Cantero, Mónica Porras, Miguel Á Tejada, Daniel Zamanillo

Life Sci· November 2025

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Resilience to Pain-Related Depression in σ Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes.
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela

ACS Chem Neurosci· October 2023

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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Daniel Zamanillo

Acta Pharm Sin B· January 2023

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Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor.
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela

ACS Pharmacol Transl Sci· April 2022

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Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice.
Núria Gaja-Capdevila, Neus Hernández, Daniel Zamanillo, Jose Miguel Vela, Manuel Merlos

Int J Mol Sci· June 2021

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Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Mireia Carcolé, Sami Kummer, Leonor Gonçalves, Daniel Zamanillo, Manuel Merlos

Br J Pharmacol· October 2019

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Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain.
Mireia Carcolé, Daniel Zamanillo, Manuel Merlos, Begoña Fernández-Pastor, David Cabañero

Front Pharmacol· May 2019

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Supraspinal and Peripheral, but Not Intrathecal, σR Blockade by S1RA Enhances Morphine Antinociception.
Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanillo

Front Pharmacol· April 2019

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Repeated Sigma-1 Receptor Antagonist MR309 Administration Modulates Central Neuropathic Pain Development After Spinal Cord Injury in Mice.
Sílvia Castany, Xavier Codony, Daniel Zamanillo, Manuel Merlos, Enrique Verdú

Front Pharmacol· March 2019

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Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.
Ángeles Montilla-García, Miguel Á Tejada, M Carmen Ruiz-Cantero, Inmaculada Bravo-Caparrós, Sandra Yeste, Daniel Zamanillo

Front Pharmacol· February 2019

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Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
Manuel Merlos, Enrique Portillo-Salido, Alex Brenchat, Bertrand Aubel, Jordi Buxens, Daniel Zamanillo

Eur J Pharmacol· August 2018

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Somatic Accumulation of GluA1-AMPA Receptors Leads to Selective Cognitive Impairments in Mice.
David M Bannerman, Thilo Borchardt, Vidar Jensen, Andrey Rozov, Nadia N Haj-Yasein, Daniel Zamanillo

Front Mol Neurosci· June 2018

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Sigma-1 Receptor and Pain.
Manuel Merlos, Luz Romero, Daniel Zamanillo, Carlos Plata-Salamán, José Miguel Vela

Handb Exp Pharmacol· April 2018

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Pharmacological sensitivity of reflexive and nonreflexive outcomes as a correlate of the sensory and affective responses to visceral pain in mice.
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, José M Vela, Manuel Merlos

Sci Rep· October 2017

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The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats.
Georgia Gris, Enrique Portillo-Salido, Bertrand Aubel, Yassine Darbaky, Kristof Deseure, Daniel Zamanillo

Sci Rep· April 2016

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Changes in saccharin preference behavior as a primary outcome to evaluate pain and analgesia in acetic acid-induced visceral pain in mice.
Beatriz de la Puente, Elizabeth Romero-Alejo, José Miguel Vela, Manuel Merlos, Daniel Zamanillo

J Pain Res· October 2015

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Sigma-1 receptor and inflammatory pain.
Georgia Gris, Enrique José Cobos, Daniel Zamanillo, Enrique Portillo-Salido

Inflamm Res· June 2015

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The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Pilar Sánchez-Blázquez, María Rodríguez-Muñoz, Raquel Herrero-Labrador, Javier Burgueño, Daniel Zamanillo

Int J Neuropsychopharmacol· December 2014

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S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
Georgia Gris, Manuel Merlos, José M Vela, Daniel Zamanillo, Enrique Portillo-Salido

Behav Pharmacol· June 2014

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Effects of the selective sigma-1 receptor antagonist S1RA on formalin-induced pain behavior and neurotransmitter release in the spinal cord in rats.
Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanillo

J Neurochem· May 2014

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Predicting the antinociceptive efficacy of σ(1) receptor ligands by a novel receptor fluorescence resonance energy transfer (FRET) based biosensor.
Maricel Gómez-Soler, Víctor Fernández-Dueñas, Enrique Portillo-Salido, Pilar Pérez, Daniel Zamanillo

J Med Chem· January 2014

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Sigma 1 receptor: a new therapeutic target for pain.
Daniel Zamanillo, Luz Romero, Manuel Merlos, José Miguel Vela

Eur J Pharmacol· September 2013

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Potentiation of morphine-induced mechanical antinociception by σ₁ receptor inhibition: role of peripheral σ₁ receptors.
Cristina Sánchez-Fernández, Francisco Rafael Nieto, Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Daniel Zamanillo

Neuropharmacology· July 2013

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Sigma-1 receptor antagonism as opioid adjuvant strategy: enhancement of opioid antinociception without increasing adverse effects.
Alba Vidal-Torres, Beatriz de la Puente, Maria Rocasalbas, Clara Touriño, Simona Andreea Bura, Daniel Zamanillo

Eur J Pharmacol· July 2013

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Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice.
Francisco Rafael Nieto, Cruz Miguel Cendán, Cristina Sánchez-Fernández, Enrique José Cobos, José Manuel Entrena, Daniel Zamanillo

J Pain· November 2012

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