Publications by authors named "Manuel Merlos"

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Resilience to Pain-Related Depression in σ Receptor Knockout Mice Is Associated with the Reversal of Pain-Induced Brain Changes in Affect-Related Genes.
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela, Manuel Merlos

ACS Chem Neurosci· October 2023

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Discovery of WLB-89462, a New Drug-like and Highly Selective σ Receptor Ligand with Neuroprotective Properties.
Ute Christmann, José Luis Díaz, Rosalia Pascual, Magda Bordas, Inés Álvarez, Manuel Merlos

J Med Chem· September 2023

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Development of a Novel σ Receptor Biosensor Based on Its Heterodimerization with Binding Immunoglobulin Protein in Living Cells.
Xavier Morató, Víctor Fernández-Dueñas, Pilar Pérez-Villamor, Marta Valle-León, José Miguel Vela, Manuel Merlos

ACS Chem Neurosci· June 2023

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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids.
Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Manuel Merlos

Acta Pharm Sin B· January 2023

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Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models.
Beltrán Álvarez-Pérez, Anna Bagó-Mas, Meritxell Deulofeu, José Miguel Vela, Manuel Merlos

Int J Mol Sci· October 2022

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Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition.
Beltrán Álvarez-Pérez, Meritxell Deulofeu, Judit Homs, Manuel Merlos, José Miguel Vela

Sci Rep· June 2022

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EST79232 and EST79376, Two Novel Sigma-1 Receptor Ligands, Exert Neuroprotection on Models of Motoneuron Degeneration.
Núria Gaja-Capdevila, Neus Hernández, Sandra Yeste, Raquel F Reinoso, Javier Burgueño, Manuel Merlos

Int J Mol Sci· June 2022

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Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor.
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela, Manuel Merlos

ACS Pharmacol Transl Sci· April 2022

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Identification of Sodium Transients Through Na1.5 Channels as Regulators of Differentiation in Immortalized Dorsal Root Ganglia Neurons.
Antón L Martínez, José Brea, Eduardo Domínguez, María J Varela, Catarina Allegue, Manuel Merlos

Front Cell Neurosci· April 2022

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Development of a novel in vitro assay to screen for neuroprotective drugs against iatrogenic neurite shortening.
Antón L Martínez, José Brea, Mateo Barro, Xavier Monroy, Manuel Merlos

PLoS One· October 2021

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Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain.
Antón L Martínez, José Brea, Eduardo Domínguez, María J Varela, Marta Cimadevila, Manuel Merlos

ACS Chem Neurosci· July 2021

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Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice.
Núria Gaja-Capdevila, Neus Hernández, Daniel Zamanillo, Jose Miguel Vela, Manuel Merlos

Int J Mol Sci· June 2021

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Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ Receptor Antagonist Clinical Candidate for the Treatment of Pain.
Mónica García, Marina Virgili, Mònica Alonso, Carles Alegret, Joan Farran, Manuel Merlos

J Med Chem· December 2020

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The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception.
Pilar Sánchez-Blázquez, Elsa Cortés-Montero, María Rodríguez-Muñoz, Manuel Merlos, Javier Garzón-Niño

Mol Brain· November 2020

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Urinary bladder sigma-1 receptors: A new target for cystitis treatment.
Rafael González-Cano, Antonia Artacho-Cordón, Lucía Romero, Miguel A Tejada, Francisco R Nieto, Manuel Merlos

Pharmacol Res· May 2020

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Outside-in regulation of the readily releasable pool of synaptic vesicles by α2δ-1.
Pablo Martínez San Segundo, Beatrice Terni, Javier Burgueño, Xavier Monroy, Albert Dordal, Manuel Merlos

FASEB J· January 2020

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Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
Mireia Carcolé, Sami Kummer, Leonor Gonçalves, Daniel Zamanillo, Manuel Merlos

Br J Pharmacol· October 2019

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Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.
Elsa Cortés-Montero, Pilar Sánchez-Blázquez, Yara Onetti, Manuel Merlos, Javier Garzón

Front Pharmacol· June 2019

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Co-crystal of tramadol-celecoxib: preclinical and clinical evaluation of a novel analgesic.
Neus Gascon, Carmen Almansa, Manuel Merlos, José Miguel Vela, Gregorio Encina

Expert Opin Investig Drugs· May 2019

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Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain.
Mireia Carcolé, Daniel Zamanillo, Manuel Merlos, Begoña Fernández-Pastor, David Cabañero

Front Pharmacol· May 2019

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Supraspinal and Peripheral, but Not Intrathecal, σR Blockade by S1RA Enhances Morphine Antinociception.
Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos

Front Pharmacol· April 2019

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May a sigma-1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
Nancy Paniagua, Carlos Goicoechea, Raquel Abalo, Visitacion López-Miranda, J Miguel Vela, Manuel Merlos

Eur J Pain· March 2019

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Repeated Sigma-1 Receptor Antagonist MR309 Administration Modulates Central Neuropathic Pain Development After Spinal Cord Injury in Mice.
Sílvia Castany, Xavier Codony, Daniel Zamanillo, Manuel Merlos, Enrique Verdú

Front Pharmacol· March 2019

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A New Model of Sensorial Neuron-Like Cells for HTS of Novel Analgesics for Neuropathic Pain.
Antón L Martínez, José Brea, Xavier Monroy, Manuel Merlos, Javier Burgueño

SLAS Discov· February 2019

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Administration of a co-crystal of tramadol and celecoxib in a 1:1 molecular ratio produces synergistic antinociceptive effects in a postoperative pain model in rats.
Manuel Merlos, Enrique Portillo-Salido, Alex Brenchat, Bertrand Aubel, Jordi Buxens

Eur J Pharmacol· August 2018

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