Publications by authors named "David A Six"

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PenI β-lactamase and variants are potently inhibited by taniborbactam.
Maria F Mojica, Scott A Becka, Mitchell Edwards, Cullen Myers, Kyoko Uehara, David A Six

Antimicrob Agents Chemother· October 2025

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Structure and mechanism of taniborbactam inhibition of the cefepime-hydrolyzing, partial R2-loop deletion -derived cephalosporinase variant PDC-88.
Andrew R Mack, Vijay Kumar, Christopher R Bethel, Magdalena A Taracila, Brittany A Miller, David A Six

Antimicrob Agents Chemother· July 2025

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Spectrum of cefepime-taniborbactam coverage against 190 β-lactamases defined in engineered isogenic strains.
Tsuyoshi Uehara, Cassandra L Chatwin, Brittany Miller, Mitchell Edwards, Annie Stevenson, David A Six

Antimicrob Agents Chemother· May 2025

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Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
James A Karlowsky, Mark G Wise, Meredith A Hackel, David A Six, Tsuyoshi Uehara

J Antimicrob Chemother· December 2024

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ARGONAUT-IV: susceptibility of carbapenemase-producing to the oral bicyclic boronate β-lactamase inhibitor ledaborbactam combined with ceftibuten.
Michael R Jacobs, Caryn E Good, Ayman M Abdelhamed, Andrew R Mack, Christopher R Bethel, David A Six

Antimicrob Agents Chemother· December 2024

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Cefepime-taniborbactam demonstrates potent activity vs with .
Maria F Mojica, Elise T Zeiser, Scott A Becka, David A Six, Greg Moeck

Microbiol Spectr· November 2024

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ARGONAUT-III and -V: susceptibility of carbapenem-resistant and multidrug-resistant to the bicyclic boronate β-lactamase inhibitor taniborbactam combined with cefepime.
Michael R Jacobs, Ayman M Abdelhamed, Caryn E Good, Andrew R Mack, Christopher R Bethel, David A Six

Antimicrob Agents Chemother· September 2024

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Examining the activity of cefepime-taniborbactam against complex and isolated from cystic fibrosis patients in the United States.
Maria F Mojica, Elise T Zeiser, Scott A Becka, John J LiPuma, David A Six

Antimicrob Agents Chemother· November 2023

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Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program.
James A Karlowsky, Meredith A Hackel, Mark G Wise, David A Six, Tsuyoshi Uehara

Antimicrob Agents Chemother· January 2023

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Metabolic Incorporation of Azido-Sugars into LPS to Enable Live-Cell Fluorescence Imaging.
Inga Nilsson, David A Six

Methods Mol Biol· September 2022

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Fluorescent sensors of siderophores produced by bacterial pathogens.
Ashish Kumar, Taihao Yang, Somnath Chakravorty, Aritri Majumdar, Brittany L Nairn, David A Six

J Biol Chem· March 2022

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The Next-Generation β-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli.
Elyse J Roach, Tsuyoshi Uehara, Denis M Daigle, David A Six, Cezar M Khursigara

Microbiol Spectr· October 2021

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Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics.
Phillip E Klebba, Salete M C Newton, David A Six, Ashish Kumar, Taihao Yang

Chem Rev· May 2021

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Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes.
Inga Nilsson, Sheng Y Lee, William S Sawyer, Christopher M Baxter Rath, Guillaume Lapointe, David A Six

J Lipid Res· June 2020

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VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in and Pseudomonas aeruginosa.
Jodie C Hamrick, Jean-Denis Docquier, Tsuyoshi Uehara, Cullen L Myers, David A Six

Antimicrob Agents Chemother· February 2020

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Defects in Efflux (), β-Lactamase (), and Lipopolysaccharide Transport () Genes Mediate Antibiotic Hypersusceptibility of Strain Z61.
Xiaoyu Shen, Nicole V Johnson, Naomi N K Kreamer, S Whitney Barnes, John R Walker, David A Six

Antimicrob Agents Chemother· July 2019

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Development and Optimization of a Higher-Throughput Bacterial Compound Accumulation Assay.
Marcella Widya, William D Pasutti, Meena Sachdeva, Robert L Simmons, Pramila Tamrakar, David A Six

ACS Infect Dis· March 2019

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The sialic acid transporter NanT is necessary and sufficient for uptake of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) and its azido analog in Escherichia coli.
Inga Nilsson, Ramadevi Prathapam, Kerri Grove, Guillaume Lapointe, David A Six

Mol Microbiol· October 2018

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Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria.
Benjamin Spangler, Dustin Dovala, William S Sawyer, Katherine V Thompson, David A Six

ACS Infect Dis· September 2018

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A pathway-directed positive growth restoration assay to facilitate the discovery of lipid A and fatty acid biosynthesis inhibitors in Acinetobacter baumannii.
Daryl L Richie, Lisha Wang, Helen Chan, Gianfranco De Pascale, David A Six

PLoS One· June 2018

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Advances and challenges in bacterial compound accumulation assays for drug discovery.
David A Six, Thomas Krucker, Jennifer A Leeds

Curr Opin Chem Biol· June 2018

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Molecular characterization and verification of azido-3,8-dideoxy-d--oct-2-ulosonic acid incorporation into bacterial lipopolysaccharide.
Inga Nilsson, Kerri Grove, Dustin Dovala, Tsuyoshi Uehara, Guillaume Lapointe, David A Six

J Biol Chem· December 2017

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Subcellular Chemical Imaging of Antibiotics in Single Bacteria Using C-Secondary Ion Mass Spectrometry.
Hua Tian, David A Six, Thomas Krucker, Jennifer A Leeds, Nicholas Winograd

Anal Chem· May 2017

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Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.
Jade Bojkovic, Daryl L Richie, David A Six, Christopher M Rath, William S Sawyer

J Bacteriol· December 2015

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Deletion of the β-acetoacetyl synthase FabY in Pseudomonas aeruginosa induces hypoacylation of lipopolysaccharide and increases antimicrobial susceptibility.
David A Six, Yanqiu Yuan, Jennifer A Leeds, Timothy C Meredith

Antimicrob Agents Chemother· September 2014

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