Publications by authors named "David Borchelt"

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Basic Science and Pathogenesis.
Conner D Angelle, Guilian Xu, Andrea Iturbe, Patricia Sacilotto, Susan Fromholt, David R Borchelt

Alzheimers Dement· December 2025

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Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits.
Guilian Xu, Conner Angelle, Divya Huilgol, Patricia Sacilotto, Karen N McFarland, David R Borchelt

Neurobiol Dis· November 2025

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Acetylation Mimetic and Null Mutations Within the Filament Core of P301L Tau Have Varied Effects on Susceptibility to Seeding and Aggregation.
Ethan D Smith, Jose Torrellas, Robert McKenna, Quan Vo, Mario Mietzsch, David R Borchelt

J Neurochem· September 2025

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Acetylation mimetic and null mutations within the filament core of P301L tau have varied effects on susceptibility to seeding and aggregation.
Ethan D Smith, Jose Torrellas, Robert McKenna, Quan Vo, Mario Mietzsch, David R Borchelt

bioRxiv· August 2025

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Progressive Supranuclear Palsy PERK haplotype B selectively translates DLX1 promoting tau toxicity.
Christian B Lessard, Diego Rubio-Rubio, Samantha Tolton, Marangelie Criado-Marrero, Sakthivel Ravi, David R Borchelt

bioRxiv· July 2025

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Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease.
Yona Levites, Eric B Dammer, Yong Ran, Wangchen Tsering, Duc Duong, David R Borchelt

Cell Rep Med· August 2024

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Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
Grace M Lloyd, Jess-Karan S Dhillon, Kimberly-Marie M Gorion, Cara Riffe, Susan E Fromholt, David R Borchelt

Mol Neurodegener· February 2024

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Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease.
Yona Levites, Eric B Dammer, Yong Ran, Wangchen Tsering, Duc Duong, David R Borchelt

bioRxiv· December 2023

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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau.
Ethan D Smith, Quan Vo, Benoit I Giasson, David R Borchelt, Stefan Prokop

Acta Neuropathol Commun· October 2023

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice.
Jacob I Ayers, Guilian Xu, Qing Lu, Kristy Dillon, Susan Fromholt, David R Borchelt

Viruses· August 2023

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Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis.
Grace M Lloyd, Brooke Long, Stephan Quintin, Zachary A Sorrentino, Kimberly-Marie M Gorion, David Borchelt

Acta Neuropathol Commun· July 2023

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Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, David R Borchelt

Acta Neuropathol Commun· June 2023

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Modeling the Competition between Misfolded Aβ Conformers That Produce Distinct Types of Amyloid Pathology in Alzheimer's Disease.
Guilian Xu, Susan Fromholt, David R Borchelt

Biomolecules· June 2022

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Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice.
Yuxing Xia, Stefan Prokop, Brach M Bell, Kimberly-Marie M Gorion, Cara L Croft, David R Borchelt

Commun Biol· May 2022

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TAPPing into the potential of inducible tau/APP transgenic mice.
Guilian Xu, Brittany S Ulm, John Howard, Susan E Fromholt, Qing Lu, David R Borchelt

Neuropathol Appl Neurobiol· April 2022

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Impact of APOE genotype on prion-type propagation of tauopathy.
Tristan Williams, Alejandra Jolie Ruiz, Angelica Maria Ruiz, Quan Vo, Wangchen Tsering, David R Borchelt

Acta Neuropathol Commun· April 2022

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Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis.
Kim A Staats, David R Borchelt, Malú Gámez Tansey, James Wymer

Mol Neurodegener· January 2022

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Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.
Brenda D Moore, Yona Levites, Guilian Xu, Hailey Hampton, Munir F Adamo, David R Borchelt

Free Neuropathol· January 2022

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Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model.
Grace M Lloyd, Jess-Karan S Dhillon, Kimberly-Marie M Gorion, Cara Riffe, Susan E Fromholt, David R Borchelt

Mol Neurodegener· September 2021

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Reactive astrocytes as treatment targets in Alzheimer's disease-Systematic review of studies using the APPswePS1dE9 mouse model.
Tamar Smit, Natasja A C Deshayes, David R Borchelt, Willem Kamphuis, Jinte Middeldorp

Glia· August 2021

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Supercharging Prions via Amyloid-Selective Lysine Acetylation.
Katelyn M Baumer, Christopher D Cook, Collin T Zahler, Alexandra A Beard, Zhijuan Chen, David R Borchelt

Angew Chem Int Ed Engl· June 2021

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Astrocytic apoE4 and tau: Deadly combination for neurons.
Paramita Chakrabarty, David R Borchelt

Cell Rep Med· June 2021

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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence.
Jacob I Ayers, Guilian Xu, Kristy Dillon, Qing Lu, Zhijuan Chen, David R Borchelt

Acta Neuropathol Commun· May 2021

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Il-10 signaling reduces survival in mouse models of synucleinopathy.
Samuel G Cockey, Karen N McFarland, Emily J Koller, Mieu M T Brooks, Elsa Gonzalez De La Cruz, David R Borchelt

NPJ Parkinsons Dis· March 2021

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Remodeling Alzheimer-amyloidosis models by seeding.
Brittany S Ulm, David R Borchelt, Brenda D Moore

Mol Neurodegener· February 2021

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