Publications by authors named "David D Christ"

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Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).
Bertrand Le Bourdonnec, Rolf T Windh, Christopher W Ajello, Lara K Leister, Minghua Gu, David D Christ

J Med Chem· October 2008

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N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.
Kan He, Mingxin Qian, Harvey Wong, Stephen A Bai, Bing He, David D Christ

J Pharm Sci· July 2008

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Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Gregory R Ott, Naoyuki Asakawa, Zhonghui Lu, Rajan Anand, Rui-Qin Liu, David D Christ

Bioorg Med Chem Lett· March 2008

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Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Zhonghui Lu, Gregory R Ott, Rajan Anand, Rui-Qin Liu, Maryanne B Covington, David D Christ

Bioorg Med Chem Lett· March 2008

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Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Gregory R Ott, Naoyuki Asakawa, Rui-Qin Liu, Maryanne B Covington, Mingxin Qian, David D Christ

Bioorg Med Chem Lett· February 2008

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Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
James J-W Duan, Lihua Chen, Zhonghui Lu, Chu-Biao Xue, Rui-Qin Liu, David D Christ

Bioorg Med Chem Lett· January 2008

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Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Gregory R Ott, Naoyuki Asakawa, Zhonghui Lu, Rui-Qin Liu, Maryanne B Covington, David D Christ

Bioorg Med Chem Lett· January 2008

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Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Mingxin Qian, Stephen A Bai, Bernice Brogdon, Jing-Tao Wu, Rui-Qin Liu, David D Christ

Drug Metab Dispos· October 2007

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CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
James R Pruitt, Douglas G Batt, Dean A Wacker, Lori L Bostrom, Shon K Booker, David D Christ

Bioorg Med Chem Lett· June 2007

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A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Xiao-Tao Chen, Bahman Ghavimi, Ronald L Corbett, Chu-Biao Xue, Rui-Qin Liu, David D Christ

Bioorg Med Chem Lett· April 2007

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The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
Harvey Wong, Scott J Grossman, Stephen A Bai, Sharon Diamond, Matthew R Wright, David D Christ

Drug Metab Dispos· December 2004

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Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, Karl D Hardman, Rui-Qin Liu, David D Christ

J Med Chem· June 2004

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Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Chu-Biao Xue, Xiaohua He, John Roderick, Ronald L Corbett, James J-W Duan, David D Christ

Bioorg Med Chem Lett· December 2003

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Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Robert J Cherney, James J-W Duan, Matthew E Voss, Lihua Chen, Li Wang, David D Christ

J Med Chem· May 2003

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Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Robert J Cherney, Ruowei Mo, Dayton T Meyer, Li Wang, Wenqing Yao, David D Christ

Bioorg Med Chem Lett· April 2003

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Development of a dog microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by methotrexate.
Mingxin Qian, Wanda West, Jing-Tao Wu, Bing Lu, David D Christ

Pharm Res· April 2003

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Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography.
Eric G Solon, Suresh K Balani, Gang Luo, Tian J Yang, Paula J Haines, David D Christ

Drug Metab Dispos· November 2002

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Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
James J-W Duan, Lihua Chen, Zelda R Wasserman, Zhonghui Lu, Rui-Qin Liu, David D Christ

J Med Chem· November 2002

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