Publications by authors named "David Howland"

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Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.
Ella W Mathews, Sydney R Coffey, Annette Gärtner, Jillian Belgrad, Robert M Bragg, David Howland

Nat Commun· November 2025

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Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.
Jillian Belgrad, Ashley Summers, Christian Landles, Jonathan R Greene, Samuel Hildebrand, David Howland

bioRxiv· June 2025

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Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models.
Marina Sogorb-Gonzalez, Christian Landles, Nicholas S Caron, Anouk Stam, Georgina Osborne, David Howland

Brain· December 2024

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Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.
Ella W Mathews, Sydney R Coffey, Annette Gärtner, Jillian Belgrad, Robert M Bragg, David Howland

bioRxiv· November 2024

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Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreas.
Robert M Bragg, Ella W Mathews, Andrea Grindeland, Jeffrey P Cantle, David Howland

Life Sci Alliance· September 2024

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An evaluation of the effectiveness of an advanced practice physiotherapist in the emergency department setting in Ireland.
David Howland, Gráinne Cunniffe, Seamus Morris, Paul Staunton

Ir J Med Sci· June 2024

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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.
Robert M Bragg, Sydney R Coffey, Jeffrey P Cantle, Shikai Hu, Sucha Singh, David Howland

Life Sci Alliance· November 2023

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Huntingtin loss in hepatocytes is associated with altered metabolism, adhesion, and liver zonation.
Robert M Bragg, Sydney R Coffey, Jeffrey P Cantle, Shikai Hu, Sucha Singh, David Howland

bioRxiv· June 2023

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Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington's Disease Sheep Support a Prodromal Disease State.
Ellen Sapp, Adel Boudi, Suzanne J Reid, Bianca A Trombetta, Pia Kivisäkk, David Howland

J Huntingtons Dis· January 2023

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Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model.
Deanna M Marchionini, Jeh-Ping Liu, Alberto Ambesi-Impiombato, Kimberly Kerker, Kim Cirillo, David Howland

JCI Insight· October 2022

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Large Animal Models of Huntington's Disease: What We Have Learned and Where We Need to Go Next.
David Howland, Zdenka Ellederova, Neil Aronin, Deborah Fernau, Jill Gallagher

J Huntingtons Dis· August 2021

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Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.
Afshin Ghavami, Michael Olsen, Mei Kwan, Jose Beltran, John Shea, David Howland

J Huntingtons Dis· April 2021

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Mutations causing Lopes-Maciel-Rodan syndrome are huntingtin hypomorphs.
Roy Jung, Yejin Lee, Douglas Barker, Kevin Correia, Baehyun Shin, David Howland

Hum Mol Genet· April 2021

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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms.
Christian Landles, Rebecca E Milton, Alexandre Jean, Stuart McLarnon, Sean J McAteer, David Howland

Brain Commun· January 2021

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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Jacob M Loupe, Ricardo Mouro Pinto, Kyung-Hee Kim, Tammy Gillis, Jayalakshmi S Mysore, David Howland

Hum Mol Genet· November 2020

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Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.
Nicholas R Franich, Miriam A Hickey, Chunni Zhu, Georgina F Osborne, Nadira Ali, David Howland

J Neurosci Res· December 2019

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Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay.
Aikaterini S Papadopoulou, Casandra Gomez-Paredes, Michael A Mason, Bridget A Taxy, David Howland

Sci Rep· November 2019

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Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease.
Huei-Bin Wang, Dawn H Loh, Daniel S Whittaker, Tamara Cutler, David Howland

eNeuro· January 2019

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Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.
Edith L Pfister, Natalie DiNardo, Erica Mondo, Florie Borel, Faith Conroy, David Howland

Hum Gene Ther· June 2018

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Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs.
Jana Krizova, Hana Stufkova, Marie Rodinova, Monika Macakova, Bozena Bohuslavova, David S Howland

Neurodegener Dis· April 2018

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MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.
Peter Langfelder, Fuying Gao, Nan Wang, David Howland, Seung Kwak

PLoS One· February 2018

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Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.
Sevasti Gaspari, Immanuel Purushothaman, Valeria Cogliani, Farhana Sakloth, Rachael L Neve, David Howland

Proc Natl Acad Sci U S A· February 2018

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Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.
Marie K Bondulich, Nelly Jolinon, Georgina F Osborne, Edward J Smith, Ivan Rattray, David Howland

Sci Rep· October 2017

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The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.
Andreas Neueder, Christian Landles, Rhia Ghosh, David Howland, Richard H Myers

Sci Rep· May 2017

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High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.
Seth A Ament, Jocelynn R Pearl, Andrea Grindeland, Jason St Claire, John C Earls, David Howland

Hum Mol Genet· March 2017

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