Publications by authors named "David J Waugh"

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Metabolic reprogramming, malignant transformation and metastasis: Lessons from chronic lymphocytic leukaemia and prostate cancer.
Madison T Hindes, Anthony M McElligott, Oliver G Best, Mark P Ward, Stavros Selemidis, David J Waugh

Cancer Lett· January 2025

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Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer.
Blossom Mak, Hui-Ming Lin, Edmond M Kwan, Heidi Fettke, Ben Tran, David J Waugh

BMC Med· March 2022

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Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells.
Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E Steele, David J Waugh

Sci Rep· February 2021

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Prostate cancer heterogeneity assessment with multi-regional sampling and alignment-free methods.
Ross G Murphy, Aideen C Roddy, Shambhavi Srivastava, Esther Baena, David J Waugh

NAR Genom Bioinform· September 2020

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ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA.
Alan R Gilmore, Matthew Alderdice, Kienan I Savage, Paul G O'Reilly, Aideen C Roddy, David J Waugh

Cancer Res· April 2019

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Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists.
Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W D Armstrong, David J Waugh

Cell Death Dis· October 2018

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Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.
Steven M Walker, Laura A Knight, Andrena M McCavigan, Gemma E Logan, Viktor Berge, David J Waugh

Eur Urol· October 2017

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Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.
Philip D Dunne, Darragh G McArt, Conor A Bradley, Paul G O'Reilly, Helen L Barrett, David J Waugh

Clin Cancer Res· August 2016

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Delivering a research-enabled multistakeholder partnership for enhanced patient care at a population level: The Northern Ireland Comprehensive Cancer Program.
Mark Lawler, Anna Gavin, Manuel Salto-Tellez, Richard D Kennedy, Sandra Van Schaeybroeck, David J Waugh

Cancer· March 2016

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PTEN deficiency promotes macrophage infiltration and hypersensitivity of prostate cancer to IAP antagonist/radiation combination therapy.
Chris W D Armstrong, Pamela J Maxwell, Chee Wee Ong, Kelly M Redmond, Christopher McCann, David J J Waugh

Oncotarget· February 2016

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CD44-mediated activation of α5β1-integrin, cortactin and paxillin signaling underpins adhesion of basal-like breast cancer cells to endothelium and fibronectin-enriched matrices.
Suzanne McFarlane, Cheryl McFarlane, Nicola Montgomery, Ashleigh Hill, David J J Waugh

Oncotarget· November 2015

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CD44 increases the efficiency of distant metastasis of breast cancer.
Suzanne McFarlane, Jonathan A Coulter, Paul Tibbits, Anthony O'Grady, Cheryl McFarlane, David J J Waugh

Oncotarget· May 2015

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The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers.
Chee Wee Ong, Pei Yi Chong, Darragh G McArt, Jason Yongsheng Chan, Hwee Tong Tan, David J J Waugh

Oncotarget· May 2015

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Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells.
Pamela J Maxwell, Jessica Neisen, Johanna Messenger, David J J Waugh

Oncotarget· July 2014

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Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis.
Clare M McCourt, Darragh G McArt, Ken Mills, Mark A Catherwood, Perry Maxwell, David J Waugh

PLoS One· April 2014

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TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.
Zenobia C D'Costa, Catherine Higgins, Chee Wee Ong, Gareth W Irwin, David Boyle, David J J Waugh

Oncotarget· March 2014

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Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma.
Pamela J Maxwell, Jonathan Coulter, Steven M Walker, Melanie McKechnie, Jessica Neisen, David J J Waugh

Eur Urol· August 2013

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Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.
Reinhold J Medina, Christina L O'Neill, T Michelle O'Doherty, Sarah E J Chambers, Jasenka Guduric-Fuchs, David J Waugh

Stem Cells· August 2013

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Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer.
Laura M Campbell, Pamela J Maxwell, David J J Waugh

Pharmaceuticals (Basel)· August 2013

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Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.
Louise Ming, Niall M Byrne, Sarah Nicole Camac, Christopher A Mitchell, Claire Ward, David J Waugh

Int J Cancer· March 2013

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Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.
Catherine Wilson, Pamela J Maxwell, Daniel B Longley, Richard H Wilson, Patrick G Johnston, David J J Waugh

PLoS One· September 2012

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Elevation of c-FLIP in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy.
Clare McCourt, Pamela Maxwell, Roberta Mazzucchelli, Rodolfo Montironi, Marina Scarpelli, David J J Waugh

Clin Cancer Res· July 2012

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CD44 enhances invasion of basal-like breast cancer cells by upregulating serine protease and collagen-degrading enzymatic expression and activity.
Nicola Montgomery, Ashleigh Hill, Suzanne McFarlane, Jessica Neisen, Anthony O'Grady, David J J Waugh

Breast Cancer Res· May 2012

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FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism.
Andrea Valentine, Martin O'Rourke, Anita Yakkundi, Jenny Worthington, Michelle Hookham, David J J Waugh

Clin Cancer Res· March 2011

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The interleukin-8 pathway in cancer.
David J J Waugh, Catherine Wilson

Clin Cancer Res· November 2008

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