Publications by authors named "David Lamb"

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New Generation Modified Azole Antifungals against Multidrug-Resistant .
Yiyuan Chen, Yunxiao Li, Kazi S Nahar, Md Mahbub Hasan, Caleb Marsh, David C Lamb

J Med Chem· July 2025

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Unique Structural Features Relate to Evolutionary Adaptation of Cytochrome P450 in the Abyssal Zone.
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, George Minasov, Jared V Goldstone

Int J Mol Sci· June 2025

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Structure-Function Analysis of the Steroid-Hydroxylating Cytochrome P450 109 (CYP109) Enzyme Family.
Siphesihle M Msweli, Tiara Padayachee, Thembeka Khumalo, David R Nelson, David C Lamb

Int J Mol Sci· June 2025

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Artificial ER-Mitochondrion Tethering Restores Erg6 Localization and Lipid Droplet Formation in and Cells.
Haiqiong Chen, Rinse de Boer, David C Lamb, Steven L Kelly, Ida J van der Klei

Contact (Thousand Oaks)· April 2025

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Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio-selective oxidation of antifungal macrolides.
Vidhi C Murarka, Jenny S Kim, David C Lamb, Steven L Kelly, Thomas L Poulos

J Biol Chem· March 2025

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Structure-Function Analysis of the Self-Sufficient CYP102 Family Provides New Insights into Their Biochemistry.
Tiara Padayachee, David C Lamb, David R Nelson, Khajamohiddin Syed

Int J Mol Sci· February 2025

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Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota.
David C Lamb, Jared V Goldstone, Djamal Brahim Belhaouari, Julien Andréani, Ayesha Farooqi

Npj Viruses· February 2025

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Unique structural features in a deep-sea CYP51 relate to high pressure adaptation.
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, George Minasov, Jared V Goldstone

Res Sq· December 2024

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Vertebrate endocrine disruptors induce sex-reversal in blue mussels.
K Garrett Evensen, Emily Rusin, William E Robinson, Claire L Price, Steven L Kelly, David C Lamb

Sci Rep· October 2024

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Cytochromes b5 Occurrence in Viruses Belonging to the Order Megavirales.
David C Lamb, Jared V Goldstone, Djamal Brahim Belhaouari, Julien Andréani, Ayesha Farooqi

Res Sq· October 2024

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Identification of Potent and Selective Inhibitors of : Structural Insights into Sterol 14α-Demethylase as a Key Drug Target.
Tatiana Y Hargrove, David C Lamb, Zdzislaw Wawrzak, Marcus Hull, Steven L Kelly

J Med Chem· May 2024

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Biosynthesis of a new skyllamycin in : a cytochrome P450 forms an epoxide in the cinnamoyl chain.
Yuhao Song, Jose A Amaya, Vidhi C Murarka, Hugo Mendez, Mark Hogan, David C Lamb

Org Biomol Chem· April 2024

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Structure-Function Analysis of the Essential P450 Drug Target, CYP121A1.
Tiara Padayachee, David C Lamb, David R Nelson, Khajamohiddin Syed

Int J Mol Sci· April 2024

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Structure-Function Analysis of the Biotechnologically Important Cytochrome P450 107 (CYP107) Enzyme Family.
Tiara Padayachee, David C Lamb, David R Nelson, Khajamohiddin Syed

Biomolecules· December 2023

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Structural modeling of cytochrome P450 51 from a deep-sea fish points to a novel structural feature in other CYP51s.
Jared V Goldstone, David C Lamb, Steven L Kelly, Galina I Lepesheva, John J Stegeman

J Inorg Biochem· August 2023

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Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics.
Tatiana Y Hargrove, David C Lamb, Jarrod A Smith, Zdzislaw Wawrzak, Steven L Kelly

Sci Rep· September 2022

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Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injury.
Eva Griesser, Tanja Schönberger, Birgit Stierstorfer, Hannah Wyatt, Wolfgang Rist, David Lamb

Am J Physiol Lung Cell Mol Physiol· August 2022

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Characterization of a Virally Encoded Flavodoxin That Can Drive Bacterial Cytochrome P450 Monooxygenase Activity.
David C Lamb, Jared V Goldstone, Bin Zhao, Li Lei, Jonathan G L Mullins

Biomolecules· August 2022

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Metabolic arsenal of giant viruses: Host hijack or self-use?
Djamal Brahim Belhaouari, Gabriel Augusto Pires De Souza, David C Lamb, Steven L Kelly, Jared V Goldstone

Elife· July 2022

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Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.
Jose A Amaya, David C Lamb, Steven L Kelly, Patrick Caffrey, Vidhi C Murarka

J Biol Chem· April 2022

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Incomplete tricarboxylic acid cycle and proton gradient in Pandoravirus massiliensis: is it still a virus?
Sarah Aherfi, Djamal Brahim Belhaouari, Lucile Pinault, Jean-Pierre Baudoin, Philippe Decloquement, David C Lamb

ISME J· March 2022

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Orphan cytochrome P450 20a1 CRISPR/Cas9 mutants and neurobehavioral phenotypes in zebrafish.
Nadja R Brun, Matthew C Salanga, Francisco X Mora-Zamorano, David C Lamb, Jared V Goldstone

Sci Rep· December 2021

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Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.
Anissa A Widjaja, Sivakumar Viswanathan, Dong Jinrui, Brijesh K Singh, Jessie Tan, David Lamb

Front Mol Biosci· September 2021

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An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury.
Huy Q Le, Matthew A Hill, Ines Kollak, Martina Keck, Victoria Schroeder, David Lamb

EMBO Rep· August 2021

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RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma.
David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S Erjefält

Respir Res· May 2021

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