Publications by authors named "David Loakes"

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S
Synthetic polymers and their potential as genetic materials.
Vitor B Pinheiro, David Loakes, Philipp Holliger

Bioessays· February 2013

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Translesion synthesis across the (6-4) photoproduct and its Dewar valence isomer by the Y-family and engineered DNA polymerases.
Junpei Yamamoto, David Loakes, Chikahide Masutani, Shizu Simmyo, Kumiko Urabe

Nucleic Acids Symp Ser (Oxf)· November 2010

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Kinetics of dCTP incorporation opposite to 7,8-dihydro-8-oxoguanine with different 5' nearest neighbors by yeast polymerase eta.
Chin Wei Yung, David Loakes, Sakae Arimoto, Kazuo Negishi, Tomoe Negishi

Nucleic Acids Symp Ser (Oxf)· November 2010

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Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release.
Hong Jin, Ann C Kelley, David Loakes, V Ramakrishnan

Proc Natl Acad Sci U S A· May 2010

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Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Sebastian Eustermann, Christoph Brockmann, Pawan Vinod Mehrotra, Ji-Chun Yang, David Loakes

Nat Struct Mol Biol· February 2010

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Evolving a polymerase for hydrophobic base analogues.
David Loakes, José Gallego, Vitor B Pinheiro, Eric T Kool, Philipp Holliger

J Am Chem Soc· October 2009

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Polymerase engineering: towards the encoded synthesis of unnatural biopolymers.
David Loakes, Philipp Holliger

Chem Commun (Camb)· August 2009

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Darwinian chemistry: towards the synthesis of a simple cell.
David Loakes, Philipp Holliger

Mol Biosyst· July 2009

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Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome.
Rebecca M Voorhees, Albert Weixlbaumer, David Loakes, Ann C Kelley, V Ramakrishnan

Nat Struct Mol Biol· May 2009

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Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53.
Tuck Seng Wong, Sridharan Rajagopalan, Fiona M Townsley, Stefan M Freund, Miriana Petrovich, David Loakes

Nucleic Acids Res· February 2009

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Influence of neighbouring base sequences on the mutagenesis induced by 7,8-dihydro-8-oxoguanine in yeast.
Chin-Wei Yung, Yoji Okugawa, Chie Otsuka, Keinosuke Okamoto, Sakae Arimoto, David Loakes

Mutagenesis· November 2008

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Nucleotide incorporation against 7,8-dihydro-8-oxoguanine is influenced by neighboring base sequences in TLS DNA polymerase reaction.
Chinwei Yung, Tetsuya Suzuki, Yoji Okugawa, Asako Kawakami, David Loakes

Nucleic Acids Symp Ser (Oxf)· April 2008

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Oligonucleotide transformation for the study of mutagenic specificities of DNA lesions in yeast.
Kazuo Negishi, Daijiro Sekine, Takumi Morimitsu, Tetsuya Suzuki, Yoji Okugawa, David Loakes

Nucleic Acids Symp Ser (Oxf)· April 2008

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Binding of MutS protein to oligonucleotides containing a methylated or an ethylated guanine residue, and correlation with mutation frequency.
Kentaro Taira, Shintaro Nakamura, Khota Nakano, Daisuke Maehara, Keinosuke Okamoto, David Loakes

Mutat Res· April 2008

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Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.
Jason D Graci, Kathleen Too, Eric D Smidansky, Jocelyn P Edathil, Eric W Barr, David Loakes

Antimicrob Agents Chemother· March 2008

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In vitro anti-malarial activity of N6-modified purine analogs.
Kathleen Too, Daniel M Brown, David Loakes, Emily Bongard, Livia Vivas

Nucleosides Nucleotides Nucleic Acids· February 2008

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Transversion-enriched sequence saturation mutagenesis (SeSaM-Tv+): a random mutagenesis method with consecutive nucleotide exchanges that complements the bias of error-prone PCR.
Tuck Seng Wong, Danilo Roccatano, David Loakes, Kang Lan Tee, Alexander Schenk

Biotechnol J· January 2008

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Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.
Jason D Graci, Daniel A Harki, Victoria S Korneeva, Jocelyn P Edathil, Kathleen Too, David Loakes

J Virol· October 2007

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Anti-malarial activity of N6-modified purine analogues.
Kathleen Too, Daniel M Brown, Emily Bongard, Vanessa Yardley, Livia Vivas, David Loakes

Bioorg Med Chem· August 2007

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Molecular breeding of polymerases for amplification of ancient DNA.
Marc d'Abbadie, Michael Hofreiter, Alexandra Vaisman, David Loakes, Didier Gasparutto

Nat Biotechnol· August 2007

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UVA-induced degradation of 8-hydroxyguanine in oligonucleotide and the effect on its activities in yeast oligonucleotide transformation assay.
Yoji Okugawa, Chie Otsuka, David Loakes, Hiroshi Sugiyama, Kazuo Negishi

Nucleic Acids Symp Ser (Oxf)· July 2007

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Mutagenic properties of ribonucleotide analogues in reverse transcription with HIV and AMV reverse transcriptases.
Tetsuya Suzuki, Toshiyuki Okada, Chie Otsuka, Kei Moriyama, David Loakes

Nucleic Acids Symp Ser (Oxf)· June 2007

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Solution structure and dynamics of DNA duplexes containing the universal base analogues 5-nitroindole and 5-nitroindole 3-carboxamide.
José Gallego, David Loakes

Nucleic Acids Res· June 2007

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Template properties of mutagenic cytosine analogues in reverse transcription.
Tetsuya Suzuki, Kei Moriyama, Chie Otsuka, David Loakes, Kazuo Negishi

Nucleic Acids Res· January 2007

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Directed evolution of DNA polymerase, RNA polymerase and reverse transcriptase activity in a single polypeptide.
Jennifer L Ong, David Loakes, Szymon Jaroslawski, Kathleen Too, Philipp Holliger

J Mol Biol· August 2006

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