Publications by authors named "David Perlin"

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Molecular landscape of the fungal plasma membrane and implications for antifungal action.
Jennifer Jiang, Mikhail V Keniya, Anusha Puri, Xueying Zhan, Jeff Cheng, David S Perlin

Nat Commun· October 2025

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replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability.
Ariel A Aptekmann, Nathaly Cabrera, Melody C Hayman, Ruth Watson, Joseph A Stewart, David S Perlin

bioRxiv· September 2025

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Omicron Subvariants Infection Kinetics and Nirmatrelvir Efficacy in Transgenic K18-hACE2 Mice.
Vijeta Sharma, Enriko Dolgov, Taylor Tillery, Camila Mendez Romero, Alberto Rojas-Triana, David S Perlin

Int J Mol Sci· September 2025

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A novel cellular tool for screening human pan-coronavirus antivirals.
Ching-Wen Chang, Neelam Oswal, Madhuvika Murugan, Kira Goldgirsh, Wenshan Tsao, David S Perlin

Antiviral Res· August 2025

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Expression of 1,3-β-glucan synthase subunits in is regulated by the cell cycle and growth conditions and at both transcriptional and post-transcriptional levels.
Irene Gonzalez-Jimenez, Mikhail V Keniya, Ariel A Aptekmann, Christopher Quinteros, Alexis Wilkerson, David S Perlin

Antimicrob Agents Chemother· August 2025

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Omicron Subvariants Infection Kinetics and Nirmatrelvir Efficacy in Transgenic K18-hACE2 Mice.
Vijeta Sharma, Enriko Dolgov, Taylor Tillery, Camila MendezRomero, Alberto Rojas-Triana, David S Perlin

bioRxiv· July 2025

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Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi.
Satish R Malwal, Rocio Garcia-Rubio, Milena Kordalewska, Hoja Patterson, Chi Zhang, David S Perlin

ACS Infect Dis· June 2025

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Genetic and Immunological Profiling of Recent SARS-CoV-2 Omicron Subvariants: Insights into Immune Evasion and Infectivity in Monoinfections and Coinfections.
Nadine Alvarez, Irene Gonzalez-Jimenez, Risha Rasheed, Kira Goldgirsh, Steven Park, David S Perlin

Viruses· June 2025

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Tolerance and heteroresistance to echinocandins in : conceptual issues, clinical implications, and outstanding questions.
Erika Shor, David S Perlin, Dimitrios P Kontoyiannis

mSphere· May 2025

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Rapid luminescence-based screening method for SARS- CoV-2 inhibitors discovery.
Abdeldjalil Madani, Nadine Alvarez, Steven Park, Madhuvika Murugan, David S Perlin

SLAS Discov· March 2025

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Broad-Spectrum Activity and Mechanisms of Action of SQ109 on a Variety of Fungi.
Satish R Malwal, Rocio Garcia-Rubio, Milena Kordalewska, Hoja Patterson, Chi Zhang, David S Perlin

bioRxiv· February 2025

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Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase.
Cindy Meyer, Aitor Garzia, Michael W Miller, David J Huggins, Robert W Myers, David S Perlin

Nature· January 2025

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In vivo antiviral efficacy of LCTG-002, a pooled, purified human milk secretory IgA product, against SARS-CoV-2 in a murine model of COVID-19.
Viraj Mane, Rikin Mehta, Nadine Alvarez, Vijeta Sharma, Steven Park, David S Perlin

Hum Vaccin Immunother· December 2024

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Evolutionary dynamics in gut-colonizing Candida glabrata during caspofungin therapy: Emergence of clinically important mutations in sphingolipid biosynthesis.
Yasmine Hassoun, Ariel A Aptekmann, Mikhail V Keniya, Rosa Y Gomez, Nicole Alayo, David S Perlin

PLoS Pathog· September 2024

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CTC-177, a novel drug-Fc conjugate, shows promise as an immunoprophylactic agent against multidrug-resistant Gram-negative bacterial infections.
Arianne Lovey, Annie Lee, Allison Yu, Mila Krel, Mingming Wang, David S Perlin

JAC Antimicrob Resist· August 2024

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Novel Pan-Coronavirus 3CL Protease Inhibitor MK-7845: Biological and Pharmacological Profiling.
Nadine Alvarez, Gregory C Adam, John A Howe, Vijeta Sharma, Matthew D Zimmerman, David S Perlin

Viruses· July 2024

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Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in .
Jennifer Jiang, Mikhail V Keniya, Anusha Puri, Xueying Zhan, Jeff Cheng, David S Perlin

bioRxiv· May 2024

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Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus .
Amir Arastehfar, Farnaz Daneshnia, Daniel J Floyd, Nathan Elias Jeffries, Mostafa Salehi, David S Perlin

mBio· April 2024

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Humoral and cellular immune responses against SARS-CoV-2 post-vaccination in immunocompetent and immunocompromised cancer populations.
Elizabeth Titova, Veronica W Kan, Tara Lozy, Andrew Ip, Kileen Shier, David S Perlin

Microbiol Spectr· March 2024

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Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
Valerie W Shurtleff, Mark E Layton, Craig A Parish, James J Perkins, John D Schreier, David S Perlin

J Med Chem· March 2024

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Genes Modulating Echinocandin Susceptibility of Caspofungin-Adapted Mutants Are Constitutively Expressed in Clinical Isolates with Intermediate or Full Resistance to Echinocandins.
Anshuman Yadav, Sudisht K Sah, David S Perlin, Elena Rustchenko

J Fungi (Basel)· March 2024

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Correction: Jiménez-Ortigosa et al. Cryo-Electron Tomography of Plasma Membrane Proteins. 2021, , 120.
Cristina Jiménez-Ortigosa, Jennifer Jiang, Muyuan Chen, Xuyuan Kuang, Kelley R Healey, David S Perlin

J Fungi (Basel)· March 2024

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Fungicide-tolerant persister formation during cryptococcal pulmonary infection.
Weixin Ke, Yuyan Xie, Yingying Chen, Hao Ding, Leixin Ye, David S Perlin

Cell Host Microbe· February 2024

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Small Molecule Benzothiophene with Efficacy in a Mouse Model of Drug-Resistant Infection.
Ricardo Gallardo-Macias, Riccardo Russo, Matthew Sherwood, Mark Jaskowski, Wissam Nasser, David Perlin

J Med Chem· January 2024

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A multidimensional assessment of in-host fitness costs of drug resistance in the opportunistic fungal pathogen Candida glabrata.
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan, Nathaly Cabrera, Macit Ilkit, David S Perlin

FEMS Yeast Res· January 2024

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