Publications by authors named "David Plouffe"

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Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.
Matthew Abraham, Kerstin Gagaring, Marisa L Martino, Manu Vanaerschot, David M Plouffe

ACS Infect Dis· April 2020

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Liver-Targeted Toll-Like Receptor 7 Agonist Combined With Entecavir Promotes a Functional Cure in the Woodchuck Model of Hepatitis B Virus.
Kyle E Korolowizc, Bin Li, Xu Huang, Changsuek Yon, Evelyn Rodrigo, David M Plouffe

Hepatol Commun· October 2019

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8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity.
Michael Leven, Jana Held, Sandra Duffy, Leandro A Alves Avelar, Stephan Meister, David Plouffe

ChemMedChem· February 2019

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Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.
Yevgeniya Antonova-Koch, Stephan Meister, Matthew Abraham, Madeline R Luth, Sabine Ottilie, David Plouffe

Science· December 2018

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Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance.
Gregory LaMonte, Michelle Yi-Xiu Lim, Melanie Wree, Christin Reimer, Marie Nachon, David Plouffe

mBio· July 2016

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Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, David M Plouffe

PLoS Pathog· July 2016

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High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
Justine Swann, Victoria Corey, Christina A Scherer, Nobutaka Kato, Eamon Comer, David Plouffe

ACS Infect Dis· April 2016

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High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
David M Plouffe, Melanie Wree, Alan Y Du, Stephan Meister, Fengwu Li

Cell Host Microbe· January 2016

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KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro.
Anne-Marie Zeeman, Sandra M van Amsterdam, Case W McNamara, Annemarie Voorberg-van der Wel, Els J Klooster, David M Plouffe

Antimicrob Agents Chemother· October 2014

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KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.
Kelli L Kuhen, Arnab K Chatterjee, Matthias Rottmann, Kerstin Gagaring, Rachel Borboa, David Plouffe

Antimicrob Agents Chemother· September 2014

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Targeting Plasmodium PI(4)K to eliminate malaria.
Case W McNamara, Marcus Cs Lee, Chek Shik Lim, Siau Hoi Lim, Jason Roland, David M Plouffe

Nature· December 2013

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Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families.
Selina E R Bopp, Micah J Manary, A Taylor Bright, Geoffrey L Johnston, Neekesh V Dharia, David Plouffe

PLoS Genet· June 2013

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Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.
Dominic Hoepfner, Case W McNamara, Chek Shik Lim, Christian Studer, Ralph Riedl, David M Plouffe

Cell Host Microbe· June 2012

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Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
Advait Nagle, Tao Wu, Kelli Kuhen, Kerstin Gagaring, Rachel Borboa, David Plouffe

J Med Chem· May 2012

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The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites.
Michael Delves, David Plouffe, Christian Scheurer, Stephan Meister, Sergio Wittlin

PLoS Med· February 2012

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Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Stephan Meister, David M Plouffe, Kelli L Kuhen, Ghislain M C Bonamy, Tao Wu

Science· December 2011

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A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.
Tae-Gyu Nam, Case W McNamara, Selina Bopp, Neekesh V Dharia, Stephan Meister, David M Plouffe

ACS Chem Biol· November 2011

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Imidazolopiperazines: hit to lead optimization of new antimalarial agents.
Tao Wu, Advait Nagle, Kelli Kuhen, Kerstin Gagaring, Rachel Borboa, David Plouffe

J Med Chem· July 2011

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Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites.
Neekesh V Dharia, David Plouffe, Selina E R Bopp, Gonzalo E González-Páez, Carmen Lucas

Genome Res· November 2010

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Spiroindolones, a potent compound class for the treatment of malaria.
Matthias Rottmann, Case McNamara, Bryan K S Yeung, Marcus C S Lee, Bin Zou, David M Plouffe

Science· September 2010

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.
Kevin Pethe, Patricia C Sequeira, Sanjay Agarwalla, Kyu Rhee, Kelli Kuhen, David Plouffe

Nat Commun· August 2010

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Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
Bryan K S Yeung, Bin Zou, Matthias Rottmann, Suresh B Lakshminarayana, Shi Hua Ang, David Plouffe

J Med Chem· July 2010

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Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.
Xianming Deng, Advait Nagle, Tao Wu, Tomoyo Sakata, Kerstin Henson, David Plouffe

Bioorg Med Chem Lett· July 2010

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Cell-based optimization of novel benzamides as potential antimalarial leads.
Tao Wu, Advait Nagle, Tomoyo Sakata, Kerstin Henson, Rachel Borboa, David Plouffe

Bioorg Med Chem Lett· December 2009

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Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Neekesh V Dharia, Amar Bir Singh Sidhu, María Belén Cassera, Scott J Westenberger, Selina Er Bopp, David Plouffe

Genome Biol· February 2009

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