Publications by authors named "David Pryde"

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Synthesis and structure-activity evaluation of a series of novel tricyclic STING activators.
Sourav Basu, Sandip Middya, Ritesh Shrivastava, David C Pryde, Rajib Ghosh

Eur J Med Chem· June 2025

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The discovery of potent small molecule cyclic urea activators of STING.
Sourav Basu, Sandip Middya, Monali Banerjee, Rajib Ghosh, David C Pryde

Eur J Med Chem· February 2022

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The discovery of potent small molecule activators of human STING.
David C Pryde, Sandip Middya, Monali Banerjee, Ritesh Shrivastava, Sourav Basu

Eur J Med Chem· January 2021

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G10 is a direct activator of human STING.
Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C Pryde

PLoS One· October 2020

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Valproic acid interactions with the NavMs voltage-gated sodium channel.
Geancarlo Zanatta, Altin Sula, Andrew J Miles, Leo C T Ng, Rubben Torella, David C Pryde

Proc Natl Acad Sci U S A· December 2019

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Design and Identification of a Novel, Functionally Subtype Selective GABA Positive Allosteric Modulator (PF-06372865).
Robert M Owen, David Blakemore, Lishuang Cao, Neil Flanagan, Rebecca Fish, David C Pryde

J Med Chem· June 2019

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A pharmacological master key mechanism that unlocks the selectivity filter gate in K channels.
Marcus Schewe, Han Sun, Ãœmit Mert, Alexandra Mackenzie, Ashley C W Pike, David C Pryde

Science· February 2019

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TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Wei Chou Tseng, David C Pryde, Katrina E Yoger, Karen M Padilla, Brett M Antonio

Proc Natl Acad Sci U S A· November 2018

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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes.
Lily T-Y Cho, Aristos J Alexandrou, Rubben Torella, John Knafels, Jake Hobbs, David C Pryde

Structure· April 2018

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Discovery of a Series of Indazole TRPA1 Antagonists.
David C Pryde, Brian E Marron, Christopher W West, Steven Reister, George Amato

ACS Med Chem Lett· June 2017

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Corrigendum to "Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1" [Bioorg. Med. Chem. Lett. 26 (2016) 4919-4924].
Aymeric Monteillier, Alexandre Loucif, Kiyoyuki Omoto, Edward B Stevens, Sergio Lainez, David C Pryde

Bioorg Med Chem Lett· May 2017

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Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.
Joshua Almond-Thynne, David C Blakemore, David C Pryde, Alan C Spivey

Chem Sci· January 2017

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Identification of Positive Allosteric Modulators of Glycine Receptors from a High-Throughput Screen Using a Fluorescent Membrane Potential Assay.
Clara Stead, Adam Brown, Cathryn Adams, Sarah J Nickolls, Gareth Young, David Pryde

J Biomol Screen· December 2016

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Analysis of Differential Efficacy and Affinity of GABA (α1/α2) Selective Modulators.
Qurrat U Ain, Robert M Owen, Kiyoyuki Omoto, Rubben Torella, Krishna C Bulusu, David C Pryde

Mol Pharm· November 2016

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Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K18.1.
Aymeric Monteillier, Alexandre Loucif, Kiyoyuki Omoto, Edward B Stevens, Sergio Lainez, David C Pryde

Bioorg Med Chem Lett· October 2016

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Structural basis for inhibition of a voltage-gated Ca channel by Ca antagonist drugs.
Lin Tang, Tamer M Gamal El-Din, Teresa M Swanson, David C Pryde, Todd Scheuer

Nature· September 2016

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Exploring the Dynamics of the TWIK-1 Channel.
Victoria Oakes, Simone Furini, David Pryde, Carmen Domene

Biophys J· August 2016

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Lateral Fenestrations in K(+)-Channels Explored Using Molecular Dynamics Simulations.
Christian Jorgensen, Leonardo Darré, Victoria Oakes, Rubben Torella, David Pryde

Mol Pharm· July 2016

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Azogabazine; a photochromic antagonist of the GABAA receptor.
Rosemary Huckvale, Martin Mortensen, David Pryde, Trevor G Smart, James R Baker

Org Biomol Chem· July 2016

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11th German Conference on Chemoinformatics (GCC 2015) : Fulda, Germany. 8-10 November 2015.
Uli Fechner, Chris de Graaf, Andrew E Torda, Stefan Güssregen, Andreas Evers, David C Pryde

J Cheminform· April 2016

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In silico identification of PAP-1 binding sites in the Kv1.2 potassium channel.
Christian Jorgensen, Leonardo Darré, Kenno Vanommeslaeghe, Kiyoyuki Omoto, David Pryde

Mol Pharm· April 2015

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Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain.
Mark D Andrews, Kerry Af Forselles, Kevin Beaumont, Sébastien R G Galan, Paul A Glossop, David C Pryde

ACS Med Chem Lett· April 2015

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A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-Ï€ interaction.
Timothy P C Rooney, Panagis Filippakopoulos, Oleg Fedorov, Sarah Picaud, Wilian A Cortopassi, David C Pryde

Angew Chem Int Ed Engl· June 2014

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Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.
Claire Bagnéris, Paul G DeCaen, Claire E Naylor, David C Pryde, Irene Nobeli

Proc Natl Acad Sci U S A· June 2014

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α-Ketophosphonates as ester surrogates: isothiourea-catalyzed asymmetric diester and lactone synthesis.
Siobhan R Smith, Stuart M Leckie, Reuben Holmes, James Douglas, Charlene Fallan, David Pryde

Org Lett· May 2014

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