Publications by authors named "David Swinney"

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Lessons learned from phenotypic drug discovery efforts.
David C Swinney

Expert Opin Drug Discov· February 2025

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Why medicines work.
David C Swinney

Pharmacol Ther· October 2022

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Fluxes for Unraveling Complex Binding Mechanisms.
Georges Vauquelin, Dominique Maes, David C Swinney

Trends Pharmacol Sci· December 2020

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Recent advances in phenotypic drug discovery.
David C Swinney, Jonathan A Lee

F1000Res· October 2020

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Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT).
Brad A Haubrich, Chakk Ramesha, David C Swinney

SLAS Discov· January 2020

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Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.
Brad A Haubrich, David C Swinney

Curr Drug Discov Technol· December 2016

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Insights into kinetic mechanism of Janus kinase 3 and its inhibition by tofacitinib.
Mohammad Hekmatnejad, Sara Conwell, Stephen M Lok, Alan Kutach, David Shaw, David C Swinney

Arch Biochem Biophys· December 2016

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Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome.
Paul J Guyett, Shuangluo Xia, David C Swinney, Michael P Pollastri, Kojo Mensa-Wilmot

ACS Infect Dis· July 2016

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The Role of Binding Kinetics in GPCR Drug Discovery.
David C Swinney, Brad A Haubrich, Isabelle Van Liefde, Georges Vauquelin

Curr Top Med Chem· May 2016

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On the different experimental manifestations of two-state 'induced-fit' binding of drugs to their cellular targets.
Georges Vauquelin, Isabelle Van Liefde, David C Swinney

Br J Pharmacol· April 2016

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A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β.
Zachary T Swinney, Brad A Haubrich, Shuangluo Xia, Chakk Ramesha, Stephen R Gomez, David C Swinney

PLoS Negl Trop Dis· March 2016

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Correction: Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
Simon P Fletcher, Daniel J Chin, Lore Gruenbaum, Hans Bitter, Erik Rasmussen, David C Swinney

PLoS Pathog· March 2016

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Radioligand binding to intact cells as a tool for extended drug screening in a representative physiological context.
Georges Vauquelin, Isabelle Van Liefde, David C Swinney

Drug Discov Today Technol· October 2015

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Intrahepatic Transcriptional Signature Associated with Response to Interferon-α Treatment in the Woodchuck Model of Chronic Hepatitis B.
Simon P Fletcher, Daniel J Chin, Lore Gruenbaum, Hans Bitter, Erik Rasmussen, David C Swinney

PLoS Pathog· September 2015

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Collaboration for rare disease drug discovery research.
Nadia K Litterman, Michele Rhee, David C Swinney, Sean Ekins

F1000Res· February 2015

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The biopharmaceutics risk assessment roadmap for optimizing clinical drug product performance.
Arzu Selen, Paul A Dickinson, Anette Müllertz, John R Crison, Hitesh B Mistry, David C Swinney

J Pharm Sci· November 2014

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands.
David C Swinney, Paul Beavis, Kai-Ting Chuang, Yue Zheng, Ina Lee

Br J Pharmacol· July 2014

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The value of translational biomarkers to phenotypic assays.
David C Swinney

Front Pharmacol· July 2014

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The discovery of medicines for rare diseases.
David C Swinney, Shuangluo Xia

Future Med Chem· June 2014

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The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines.
David C Swinney

J Biomol Screen· December 2013

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Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
Seungtaek Kim, Hisashi Ishida, Daisuke Yamane, MinKyung Yi, David C Swinney

J Virol· April 2013

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Transcriptomic analysis of the woodchuck model of chronic hepatitis B.
Simon P Fletcher, Daniel J Chin, Yongmei Ji, A Leonardo Iniguez, Bruce Taillon, David C Swinney

Hepatology· September 2012

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3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Michael Soth, Sarah Abbot, Allassan Abubakari, Nidhi Arora, Humberto Arzeno, David C Swinney

Bioorg Med Chem Lett· June 2011

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How were new medicines discovered?
David C Swinney, Jason Anthony

Nat Rev Drug Discov· June 2011

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Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity.
Zhinan Jin, Jerome Deval, Kenneth A Johnson, David C Swinney

J Biol Chem· January 2011

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