Publications by authors named "David V Hansen"

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Cellf-deception: human microglia clone 3 (HMC3) cells exhibit more astrocyte-like than microglia-like gene expression.
Kylee K Rahm, Branden S Kinghorn, Myanna J Moody, Ben C Stone, Kenton C Strong, David V Hansen

Front Bioinform· November 2025

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High-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time.
Chao Wang, Hsien-Jung L Lin, Siqi Huang, Garrett D Haynie, Kenneth S Triggs, David V Hansen

Res Sq· November 2025

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Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.
Yi-Chun Hsiao, Heidi Ackerly Wallweber, Robert G Alberstein, Zhonghua Lin, Changchun Du, David V Hansen

Nat Commun· September 2024

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Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer's Disease and Multiple Sclerosis.
Ainhoa Etxeberria, Yun-An A Shen, Stephen Vito, Sean M Silverman, Jose Imperio, David V Hansen

J Neurosci· July 2024

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TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Seung-Hye Lee, Mitchell G Rezzonico, Brad A Friedman, Melanie H Huntley, William J Meilandt, David V Hansen

Cell Rep· December 2021

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Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Seung-Hye Lee, William J Meilandt, Luke Xie, Vineela D Gandham, Hai Ngu, David V Hansen

Neuron· April 2021

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Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.
Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, David V Hansen

Cell Rep· June 2020

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
William J Meilandt, Hai Ngu, Alvin Gogineni, Guita Lalehzadeh, Seung-Hye Lee, David V Hansen

J Neurosci· February 2020

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Genome-Wide Analysis of Differential Gene Expression and Splicing in Excitatory Neurons and Interneuron Subtypes.
Melanie A Huntley, Karpagam Srinivasan, Brad A Friedman, Tzu-Ming Wang, Ada X Yee, David V Hansen

J Neurosci· January 2020

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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Tiffany Wu, Borislav Dejanovic, Vineela D Gandham, Alvin Gogineni, Rose Edmonds, David V Hansen

Cell Rep· August 2019

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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.
Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, David V Hansen

PLoS Genet· November 2018

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A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains.
Patrick C G Haddick, Jessica L Larson, Nisha Rathore, Tushar R Bhangale, Qui T Phung, David V Hansen

J Alzheimers Dis· February 2018

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Microglia in Alzheimer's disease.
David V Hansen, Jesse E Hanson, Morgan Sheng

J Cell Biol· February 2018

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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models.
Brad A Friedman, Karpagam Srinivasan, Gai Ayalon, William J Meilandt, Han Lin, David V Hansen

Cell Rep· January 2018

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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation.
Michael C Chang, Karpagam Srinivasan, Brad A Friedman, Eric Suto, Zora Modrusan, David V Hansen

J Exp Med· September 2017

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TREM2, Microglia, and Neurodegenerative Diseases.
Felix L Yeh, David V Hansen, Morgan Sheng

Trends Mol Med· June 2017

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Interfering with the Chronic Immune Response Rescues Chronic Degeneration After Traumatic Brain Injury.
Ali Ertürk, Susanne Mentz, Erik E Stout, Maj Hedehus, Sara L Dominguez, David V Hansen

J Neurosci· September 2016

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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement.
Seung-Hye Lee, Claire E Le Pichon, Oskar Adolfsson, Valérie Gafner, Maria Pihlgren, David V Hansen

Cell Rep· August 2016

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Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses.
Karpagam Srinivasan, Brad A Friedman, Jessica L Larson, Benjamin E Lauffer, Leonard D Goldstein, David V Hansen

Nat Commun· April 2016

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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Monica K Wetzel-Smith, Julie Hunkapiller, Tushar R Bhangale, Karpagam Srinivasan, Janice A Maloney, David V Hansen

Nat Med· December 2014

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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences.
David V Hansen, Jan H Lui, Pierre Flandin, Kazuaki Yoshikawa, John L Rubenstein

Nat Neurosci· November 2013

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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex.
Bridget E LaMonica, Jan H Lui, David V Hansen, Arnold R Kriegstein

Nat Commun· October 2013

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A high-resolution enhancer atlas of the developing telencephalon.
Axel Visel, Leila Taher, Hani Girgis, Dalit May, Olga Golonzhka, David V Hansen

Cell· February 2013

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Development and evolution of the human neocortex.
Jan H Lui, David V Hansen, Arnold R Kriegstein

Cell· July 2011

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Deriving excitatory neurons of the neocortex from pluripotent stem cells.
David V Hansen, John L R Rubenstein, Arnold R Kriegstein

Neuron· May 2011

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