Publications by authors named "David Zembower"

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Methylenedioxy- and ethylenedioxy-fused indolocarbazoles: potent human topoisomerase I inhibitors and antitumor agents.
David E Zembower, Yongping Xie, Ali Koohang, Mary J Kuffel, Matthew M Ames

Anticancer Agents Med Chem· November 2012

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Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.
Vincent Sandanayaka, Bjorn Mamat, Rama K Mishra, Jennifer Winger, Michael Krohn, David E Zembower

J Med Chem· January 2010

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Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.
Jasbir Singh, Wayne Zeller, Nian Zhou, Georgeta Hategan, Rama K Mishra, David E Zembower

J Med Chem· January 2010

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Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051.
Livia A Enache, Jun Zhang, David W Sullins, Isaac Kennedy, Emmanuel Onua, David E Zembower

Bioorg Med Chem Lett· November 2009

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Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
Douglas R Davies, Bjorn Mamat, Olafur T Magnusson, Jeff Christensen, Magnus H Haraldsson, David Zembower

J Med Chem· August 2009

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Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.
Jasbir Singh, Wayne Zeller, Nian Zhou, Georgeta Hategen, Rama Mishra, David Zembower

ACS Chem Biol· February 2009

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Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Bart L Staker, Michael D Feese, Mark Cushman, Yves Pommier, David Zembower

J Med Chem· April 2005

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Efficient reversed-phase purification of a hydrophobic reaction product following Mitsunobu-mediated glycosylation.
Mani S Iyer, Martin Palomo, Kevin M Schilling, Yongping Xie, Leo Formanski, David E Zembower

J Chromatogr A· January 2002

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