Publications by authors named "Dean Madden"

Claim this Profile
S
Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
Jeanine F Amacher, Patrick R Cushing, Lars Vouilleme, Sierra N Cullati, Bin Deng, Dean R Madden

J Mol Biol· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
Jeanine F Amacher, Patrick R Cushing, Lars Vouilleme, Sierra N Cullati, Bin Deng, Dean R Madden

bioRxiv· September 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in Pseudomonas aeruginosa.
Susu He, Noor M Taher, Adam R Simard, Kelli L Hvorecny, Michael J Ragusa, Dean R Madden

Nucleic Acids Res· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Molecular basis for the transcriptional regulation of an epoxide-based virulence circuit in .
Susu He, Noor M Taher, Kelli L Hvorecny, Michael J Ragusa, Christopher D Bahl, Dean R Madden

bioRxiv· January 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Unigems: plasmids and parts to facilitate teaching on assembly, gene expression control and logic in .
Alex Siddall, Abbie Ann Williams, Jason Sanders, Jai A Denton, Dean Madden

Access Microbiol· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.
Elise F Tahti, Jadon M Blount, Sophie N Jackson, Melody Gao, Nicholas P Gill, Dean R Madden

Protein Sci· April 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets.
Elise F Tahti, Jadon M Blount, Sophie N Jackson, Melody Gao, Nicholas P Gill, Dean R Madden

bioRxiv· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10.
Colin T Sheehan, Thomas H Hampton, Dean R Madden

J Biol Chem· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
George A O'Toole, Aurélie Crabbé, Rolf Kümmerli, John J LiPuma, Jennifer M Bomberger, Dean R Madden

mBio· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Biochemical and structural characterization of two cif-like epoxide hydrolases from .
Noor M Taher, Kelli L Hvorecny, Cassandra M Burke, Morgan S A Gilman, Gary E Heussler, Dean R Madden

Curr Res Struct Biol· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Specificity in PDZ-peptide interaction networks: Computational analysis and review.
Jeanine F Amacher, Lionel Brooks, Thomas H Hampton, Dean R Madden

J Struct Biol X· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Computational Analysis of Energy Landscapes Reveals Dynamic Features That Contribute to Binding of Inhibitors to CFTR-Associated Ligand.
Graham T Holt, Jonathan D Jou, Nicholas P Gill, Anna U Lowegard, Jeffrey W Martin, Dean R Madden

J Phys Chem B· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).
Natalia Vasylieva, Seiya Kitamura, Jiexian Dong, Bogdan Barnych, Kelli L Hvorecny, Dean R Madden

Anal Chim Acta· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev, Dean R Madden

Biosci Rep· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction: Cysteine modification reveals an allosteric inhibitory site on the CAL PDZ domain.
Yu Zhao, Patrick R Cushing, David C Smithson, Maria Pellegrini, Alexandre A Pletnev, Dean R Madden

Biosci Rep· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to "A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch".
Jeanine F Amacher, Fangfang Zhong, George P Lisi, Michael Q Zhu, Stephanie L Alden, Dean R Madden

J Am Chem Soc· March 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Kelli L Hvorecny, Emily Dolben, Sophie Moreau-Marquis, Thomas H Hampton, Tamer B Shabaneh, Dean R Madden

Am J Physiol Lung Cell Mol Physiol· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of the process of inverted peptides (PIPE) to screen PDZ domain ligands.
Quentin Seisel, Marisa Rädisch, Nicholas P Gill, Dean R Madden, Prisca Boisguerin

Bioorg Med Chem Lett· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.
Carol A Bertrand, Shalini Mitra, Sanjay K Mishra, Xiaohui Wang, Yu Zhao, Dean R Madden

Am J Physiol Lung Cell Mol Physiol· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
Kelli L Hvorecny, Christopher D Bahl, Seiya Kitamura, Kin Sing Stephen Lee, Bruce D Hammock, Dean R Madden

Structure· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
Christopher D Bahl, Jessica D St Laurent, R Siva Ganesa Karthikeyan, J Lakshmi Priya, Lalitha Prajna, Dean R Madden

Cornea· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.
Becca A Flitter, Kelli L Hvorecny, Emiko Ono, Taylor Eddens, Jun Yang, Dean R Madden

Proc Natl Acad Sci U S A· January 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain.
Rasmus P Clausen, Andreas Ø Mohr, Erik Riise, Anders A Jensen, Avinash Gill, Dean R Madden

Int J Biol Macromol· November 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.
Seiya Kitamura, Kelli L Hvorecny, Jun Niu, Bruce D Hammock, Dean R Madden

J Med Chem· May 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.
Christopher D Bahl, Kelli L Hvorecny, Christophe Morisseau, Scott A Gerber, Dean R Madden

Biochemistry· February 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis