Publications by authors named "Deborah F Smith"

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Novel Thienopyrimidine Inhibitors of -Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.
Andrew S Bell, Zhiyong Yu, Jennie A Hutton, Megan H Wright, James A Brannigan, Deborah F Smith

J Med Chem· July 2020

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Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.
Daniel Paape, Catriona T Prendergast, Helen P Price, Johannes S P Doehl, Deborah F Smith

Parasit Vectors· March 2020

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A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH.
Mohamed Osman, Anoop Mistry, Ada Keding, Rhian Gabe, Elizabeth Cook, Deborah F Smith

PLoS Negl Trop Dis· May 2017

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Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host.
Johannes S P Doehl, Jovana Sádlová, Hamide Aslan, Kateřina Pružinová, Sonia Metangmo, Deborah F Smith

PLoS Pathog· January 2017

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Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite .
Megan H Wright, Daniel Paape, Helen P Price, Deborah F Smith, Edward W Tate

ACS Infect Dis· June 2016

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Discovery of high affinity inhibitors of -myristoyltransferase.
Mark D Rackham, Zhiyong Yu, James A Brannigan, William P Heal, Daniel Paape, Deborah F Smith

Medchemcomm· October 2015

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Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World.
Kayla C King, Rike B Stelkens, Joanne P Webster, Deborah F Smith, Michael A Brockhurst

PLoS Pathog· September 2015

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Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.
Megan H Wright, Daniel Paape, Elisabeth M Storck, Remigiusz A Serwa, Deborah F Smith

Chem Biol· March 2015

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Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.
Daniel Paape, Andrew S Bell, William P Heal, Jennie A Hutton, Robin J Leatherbarrow, Deborah F Smith

PLoS Negl Trop Dis· December 2014

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Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
Jennie A Hutton, Victor Goncalves, James A Brannigan, Daniel Paape, Megan H Wright, Deborah F Smith

J Med Chem· October 2014

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Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.
James A Brannigan, Shirley M Roberts, Andrew S Bell, Jennie A Hutton, Michael R Hodgkinson, Deborah F Smith

IUCrJ· July 2014

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Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population.
Matthew B Rogers, Tim Downing, Barbara A Smith, Hideo Imamura, Mandy Sanders, Deborah F Smith

PLoS Genet· January 2014

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The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host.
Helen P Price, Daniel Paape, Michael R Hodgkinson, Katie Farrant, Johannes Doehl, Deborah F Smith

Mol Microbiol· November 2013

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Functional analysis of Leishmania cyclopropane fatty acid synthetase.
Samuel O Oyola, Krystal J Evans, Terry K Smith, Barbara A Smith, James D Hilley, Deborah F Smith

PLoS One· June 2013

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Identification of Drosophila gene products required for phagocytosis of Leishmania donovani.
Adam Peltan, Laura Briggs, Gareth Matthews, Sean T Sweeney, Deborah F Smith

PLoS One· June 2013

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Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei.
Glyn R Hemsworth, Helen P Price, Deborah F Smith, Keith S Wilson

Protein Sci· February 2013

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Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
Andrew S Bell, James E Mills, Gareth P Williams, James A Brannigan, Anthony J Wilkinson, Deborah F Smith

PLoS Negl Trop Dis· August 2012

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A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Helen P Price, Michael R Hodgkinson, Megan H Wright, Edward W Tate, Barbara A Smith, Deborah F Smith

Biochim Biophys Acta· July 2012

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The orthologue of Sjögren's syndrome nuclear autoantigen 1 (SSNA1) in Trypanosoma brucei is an immunogenic self-assembling molecule.
Helen P Price, Michael R Hodgkinson, Rachel S Curwen, Lorna M MacLean, James A Brannigan, Barbara A Smith, Deborah F Smith

PLoS One· June 2012

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Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion.
Lorna M Maclean, Peter J O'Toole, Meg Stark, Jo Marrison, Claudia Seelenmeyer, Deborah F Smith

Cell Microbiol· May 2012

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Therapeutic vaccination with recombinant adenovirus reduces splenic parasite burden in experimental visceral leishmaniasis.
Asher Maroof, Najmeeyah Brown, Barbara Smith, Michael R Hodgkinson, Alice Maxwell, Deborah F Smith

J Infect Dis· March 2012

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GeneDB--an annotation database for pathogens.
Flora J Logan-Klumpler, Nishadi De Silva, Ulrike Boehme, Matthew B Rogers, Giles Velarde, Deborah F Smith

Nucleic Acids Res· January 2012

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Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Matthew B Rogers, James D Hilley, Nicholas J Dickens, Jon Wilkes, Paul A Bates, Deborah F Smith

Genome Res· December 2011

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Structural basis of molecular recognition of the Leishmania small hydrophilic endoplasmic reticulum-associated protein (SHERP) at membrane surfaces.
Benjamin Moore, Andrew J Miles, Cristina Guerra-Giraldez, Peter Simpson, Momi Iwata, Deborah F Smith

J Biol Chem· March 2011

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Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.
Daniel P Depledge, Lorna M MacLean, Michael R Hodgkinson, Barbara A Smith, Andrew P Jackson, Deborah F Smith

PLoS Negl Trop Dis· September 2010

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