Publications by authors named "Deborah H Spector"

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SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus.
Emilie Branche, Ying-Ting Wang, Karla M Viramontes, Joan M Valls Cuevas, Jialei Xie, Deborah H Spector

Nat Commun· September 2022

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Zika virus is transmitted in neural progenitor cells via cell-to-cell spread and infection is inhibited by the autophagy inducer trehalose.
Alex E Clark, Zhe Zhu, Florian Krach, Jeremy N Rich, Gene W Yeo, Deborah H Spector

J Virol· March 2021

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A vaccine containing highly purified virus particles in adjuvant provides high level protection against genital infection and disease in guinea pigs challenged intravaginally with homologous and heterologous strains of herpes simplex virus type 2.
David I Bernstein, Christopher S Morello, Rhonda D Cardin, Fernando J Bravo, Kimberly A Kraynyak, Deborah H Spector

Vaccine· January 2020

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Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms.
Alex E Clark, Maite Sabalza, Philip L S M Gordts, Deborah H Spector

J Virol· March 2018

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RNA-binding protein CPEB1 remodels host and viral RNA landscapes.
Ranjan Batra, Thomas J Stark, Alex E. Clark, Jean-Philippe Belzile, Emily C Wheeler, Deborah H Spector

Nat Struct Mol Biol· December 2016

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Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.
Jean-Philippe Belzile, Maite Sabalza, Megan Craig, Alex E Clark, Christopher S Morello, Deborah H Spector

J Virol· February 2016

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Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5.
Alex E Clark, Deborah H Spector

J Virol· July 2015

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Human cytomegalovirus riding the cell cycle.
Deborah H Spector

Med Microbiol Immunol· June 2015

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IUGR and congenital cytomegalovirus infection.
Deborah H Spector

J Infect Dis· May 2014

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Human cytomegalovirus infection of human embryonic stem cell-derived primitive neural stem cells is restricted at several steps but leads to the persistence of viral DNA.
Jean-Philippe Belzile, Thomas J Stark, Gene W Yeo, Deborah H Spector

J Virol· April 2014

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25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.
Norihito Shibata, Aaron F Carlin, Nathanael J Spann, Kaoru Saijo, Christopher S Morello, Deborah H Spector

J Biol Chem· December 2013

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Infection of vascular endothelial cells with human cytomegalovirus under fluid shear stress reveals preferential entry and spread of virus in flow conditions simulating atheroprone regions of the artery.
Jenny B DuRose, Julie Li, Shu Chien, Deborah H Spector

J Virol· December 2012

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A mutation deleting sequences encoding the amino terminus of human cytomegalovirus UL84 impairs interaction with UL44 and capsid localization.
Blair L Strang, Brian J Bender, Mayuri Sharma, Jean M Pesola, Rebecca L Sanders, Deborah H Spector

J Virol· October 2012

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Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge.
Christopher S Morello, Kimberly A Kraynyak, Michael S Levinson, Zhijiang Chen, Kuo-Fen Lee, Deborah H Spector

Vaccine· October 2012

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High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection.
Thomas J Stark, Justin D Arnold, Deborah H Spector, Gene W Yeo

J Virol· January 2012

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Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32.
Sarah W Burgdorf, Charles L Clark, James R Burgdorf, Deborah H Spector

J Virol· November 2011

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Immunization with herpes simplex virus 2 (HSV-2) genes plus inactivated HSV-2 is highly protective against acute and recurrent HSV-2 disease.
Christopher S Morello, Michael S Levinson, Kimberly A Kraynyak, Deborah H Spector

J Virol· April 2011

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Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1.
Karen Tran, Jeremy P Kamil, Donald M Coen, Deborah H Spector

J Virol· October 2010

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Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.
Rebecca L Sanders, Deborah H Spector

J Virol· May 2010

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Proteasome subunits relocalize during human cytomegalovirus infection, and proteasome activity is necessary for efficient viral gene transcription.
Karen Tran, Jeffrey A Mahr, Deborah H Spector

J Virol· March 2010

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Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription.
Anokhi J Kapasi, Charles L Clark, Karen Tran, Deborah H Spector

J Virol· June 2009

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Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomes.
Rebecca L Sanders, Christia J Del Rosario, Elizabeth A White, Deborah H Spector

J Virol· November 2008

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Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.
Rebecca L Sanders, Charles L Clark, Christopher S Morello, Deborah H Spector

J Virol· July 2008

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Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.
Karen Tran, Jeffrey A Mahr, Jiwon Choi, Jose G Teodoro, Michael R Green, Deborah H Spector

J Virol· January 2008

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A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.
Finn Grey, Heather Meyers, Elizabeth A White, Deborah H Spector, Jay Nelson

PLoS Pathog· November 2007

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