Publications by authors named "Debra Dugger"

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Author Correction: Activity of caspase-8 determines plasticity between cell death pathways.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Rohit Reja

Nature· January 2026

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Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Kim Newton, Katherine E Wickliffe, Debra L Dugger, Allie Maltzman, Merone Roose-Girma

Nature· December 2025

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cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Juan Reyes

Cell Death Differ· December 2025

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Impairment of DET1 causes neurological defects and lethality in mice and humans.
Ozge Karayel, Allison Soung, Hem Gurung, Alexander F Schubert, Susan Klaeger, Debra L Dugger

Proc Natl Acad Sci U S A· February 2025

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Caspase cleavage of RIPK3 after Asp is dispensable for mouse embryogenesis.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Joshua D Webster

Cell Death Differ· February 2024

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XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death.
Axel Witt, Tatiana Goncharov, Yujung Michelle Lee, Matthias Kist, Monika Dohse, Debra Dugger

Cell Death Dis· April 2023

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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death.
Matthias Kist, László G Kőműves, Tatiana Goncharov, Debra L Dugger, Charles Yu

Cell Death Differ· March 2021

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Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D Webster, Hai Ngu, Debra L Dugger

Cell· September 2020

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.
Snahel Patel, Joshua D Webster, Eugene Varfolomeev, Youngsu C Kwon, Jason H Cheng, Debra L Dugger

Cell Death Differ· January 2020

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Activity of caspase-8 determines plasticity between cell death pathways.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Rohit Reja

Nature· November 2019

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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Kim Newton, Katherine E Wickliffe, Debra L Dugger, Allie Maltzman, Merone Roose-Girma

Nature· October 2019

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The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.
Nina Oberbeck, Victoria C Pham, Joshua D Webster, Rohit Reja, Christine S Huang, Debra L Dugger

Nature· October 2019

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Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.
Jieqiong Zhang, Joshua D Webster, Debra L Dugger, Tatiana Goncharov, Merone Roose-Girma

Cell Rep· May 2019

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Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1.
Meng He, Mira S Chaurushiya, Joshua D Webster, Sarah Kummerfeld, Rohit Reja, Debra L Dugger

Science· April 2019

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Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.
Kim Newton, Debra L Dugger, Arundhati Sengupta-Ghosh, Ronald E Ferrando, Felix Chu

Proc Natl Acad Sci U S A· October 2018

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OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Klaus Heger, Katherine E Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L Dugger

Nature· July 2018

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RIPK1 inhibits ZBP1-driven necroptosis during development.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Andreas Strasser

Nature· December 2016

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Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Ingrid E Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam, Debra Dugger

Nature· April 2016

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β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.
Rowena Suriben, Kelly A Kaihara, Magdalena Paolino, Mike Reichelt, Sarah K Kummerfeld, Debra L Dugger

Cell· December 2015

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Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Ingrid E Wertz, Kim Newton, Dhaya Seshasayee, Saritha Kusam, Cynthia Lam, Debra Dugger

Nature· December 2015

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Kim Newton, Debra L Dugger, Katherine E Wickliffe, Neeraj Kapoor, M Cristina de Almagro

Science· March 2014

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Is SIRT2 required for necroptosis?
Kim Newton, Joanne M Hildebrand, Zhirong Shen, Diego Rodriguez, Silvia Alvarez-Diaz, Debra L Dugger

Nature· February 2014

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Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer.
Jagath R Junutula, Kelly M Flagella, Richard A Graham, Kathryn L Parsons, Edward Ha, Debra L Dugger

Clin Cancer Res· October 2010

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Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice.
Nelson L Jumbe, Yan Xin, Douglas D Leipold, Lisa Crocker, Debra Dugger

J Pharmacokinet Pharmacodyn· June 2010

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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate.
Gail D Lewis Phillips, Guangmin Li, Debra L Dugger, Lisa M Crocker, Kathryn L Parsons

Cancer Res· November 2008

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