Publications by authors named "Derek Piper"

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Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
Essa Hu, Fang-Tsao Hong, Jennifer Aral, Jason Long, Derek E Piper

J Med Chem· March 2021

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BacMam production of active recombinant lecithin-cholesterol acyltransferase: Expression, purification and characterization.
William G Romanow, Derek E Piper, Preston Fordstrom, Stephen Thibault, Mingyue Zhou

Protein Expr Purif· September 2016

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Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism.
Ruwanthi N Gunawardane, Preston Fordstrom, Derek E Piper, Stephanie Masterman, Sophia Siu

J Biol Chem· February 2016

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The high-resolution crystal structure of human LCAT.
Derek E Piper, William G Romanow, Ruwanthi N Gunawardane, Preston Fordstrom, Stephanie Masterman

J Lipid Res· September 2015

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.
Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Derek E Piper

J Pharmacol Exp Ther· April 2015

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Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
Zhihong Li, Xianghong Wang, John Eksterowicz, Michael W Gribble, Grace Q Alba, Derek E Piper

J Med Chem· April 2014

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Discovery and optimization of a series of liver X receptor antagonists.
XianYun Jiao, David J Kopecky, Ben Fisher, Derek E Piper, Marc Labelle

Bioorg Med Chem Lett· September 2012

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Discovery of a new binding mode for a series of liver X receptor agonists.
David J Kopecky, Xian Yun Jiao, Ben Fisher, Sharon McKendry, Marc Labelle, Derek E Piper

Bioorg Med Chem Lett· April 2012

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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Joyce C Y Chan, Derek E Piper, Qiong Cao, Dongming Liu, Chadwick King

Proc Natl Acad Sci U S A· June 2009

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Molecular basis of PCSK9 function.
Gilles Lambert, Francesca Charlton, Kerry-Anne Rye, Derek E Piper

Atherosclerosis· March 2009

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The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol.
Derek E Piper, Simon Jackson, Qiang Liu, William G Romanow, Susan Shetterly

Structure· May 2007

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Novel inhibitors of hepatitis C virus RNA-dependent RNA polymerases.
Gary Lee, Derek E Piper, Zhulun Wang, John Anzola, Jay Powers

J Mol Biol· April 2006

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SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
Jay P Powers, Derek E Piper, Yang Li, Veronica Mayorga, John Anzola

J Med Chem· February 2006

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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
Sylvia Herter, Derek E Piper, Wade Aaron, Timothy Gabriele, Gene Cutler

Biochem J· August 2005

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Infections and severe sepsis in solid-organ transplant patients admitted from a university-based ED.
Stephen Trzeciak, Randall Sharer, Derek Piper, Therese Chan, Chad Kessler

Am J Emerg Med· November 2004

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