Publications by authors named "Dieter Edbauer"

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Homozygosity for the C allele at rs12608932 seems to compromise cognition in ALS independently of the cognitive domains.
Annaliis Lehto, Andreas Zapf, Andreas Hermann, Judith Machts, Stefan Vielhaber, Dieter Edbauer

Amyotroph Lateral Scler Frontotemporal Degener· January 2026

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Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding.
Francesca Simonetti, Weijia Zhong, Saskia Hutten, Federico Uliana, Martina Schifferer, Dieter Edbauer

EMBO J· December 2025

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Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control.
Geraldine Rodschinka, Sergio Forcelloni, Felix M Kühner, Sascha Wani, Henrick Riemenschneider, Dieter Edbauer

Nat Struct Mol Biol· October 2025

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Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.
Ali Rezaei, Virág Kocsis-Jutka, Zeynep I Gunes, Qing Zeng, Georg Kislinger, Dieter Edbauer

Nat Commun· April 2025

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Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing.
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Dieter Edbauer

Nat Commun· April 2025

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Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects.
Hortense de Calbiac, Solène Renault, Grégoire Haouy, Vincent Jung, Kevin Roger, Dieter Edbauer

Autophagy· October 2024

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Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.
Kohji Mori, Thomas Arzberger, Friedrich A Grässer, Ilse Gijselinck, Stephanie May, Dieter Edbauer

Acta Neuropathol· October 2024

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Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Dieter Edbauer

Nat Neurosci· September 2024

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Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Dieter Edbauer

EMBO Rep· July 2024

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Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
Marvin Reich, Matthew J Simon, Beate Polke, Iñaki Paris, Georg Werner, Dieter Edbauer

Sci Transl Med· June 2024

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Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target.
Lucas Caldi Gomes, Sonja Hänzelmann, Fabian Hausmann, Robin Khatri, Sergio Oller, Dieter Edbauer

Nat Commun· June 2024

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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits.
Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K Schmidt, Dieter Edbauer

Mol Neurodegener· June 2024

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Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing.
Cyril Pottier, Fahri Küçükali, Matt Baker, Anthony Batzler, Gregory D Jenkins, Dieter Edbauer

medRxiv· June 2024

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Development and Preclinical Evaluation of a Copper-64-Labeled Antibody Targeting Glycine-Alanine Dipeptides for PET Imaging of C9orf72-Associated Amyotrophic Lateral Sclerosis/Frontotemporal Dementia.
Monireh Shojaei, Qihui Zhou, Giovanna Palumbo, Rebecca Schaefer, Janne Kaskinoro, Dieter Edbauer

ACS Pharmacol Transl Sci· May 2024

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A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosis.
Fabian Hausmann, Lucas Caldi Gomes, Sonja Hänzelmann, Robin Khatri, Sergio Oller, Dieter Edbauer

Gigascience· January 2024

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C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.
Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep· August 2023

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Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo.
Henrick Riemenschneider, Francesca Simonetti, Udit Sheth, Eszter Katona, Stefan Roth, Dieter Edbauer

Acta Neuropathol Commun· July 2023

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Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased , and .
Katrin Hipke, Bettina Pitter, Alexander Hruscha, Frauke van Bebber, Miha Modic, Dieter Edbauer

Front Cell Dev Biol· June 2023

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Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.
Laura Strohm, Zehan Hu, Yongwon Suk, Alina Rühmkorf, Erin Sternburg, Dieter Edbauer

Life Sci Alliance· November 2022

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A perturbed network in neurodegeneration.
Jean-Marc Gallo, Dieter Edbauer

Science· October 2022

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Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons.
Henrick Riemenschneider, Qiang Guo, Jakob Bader, Frédéric Frottin, Daniel Farny, Dieter Edbauer

EMBO Rep· June 2022

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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (GC) expression in C9orf72 ALS/FTD.
Mareike Czuppa, Ashutosh Dhingra, Qihui Zhou, Carina Schludi, Laura König, Dieter Edbauer

Cell Rep· June 2022

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Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation.
Lara A Gruijs da Silva, Francesca Simonetti, Saskia Hutten, Henrick Riemenschneider, Erin L Sternburg, Dieter Edbauer

EMBO J· April 2022

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The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene.
Kohji Mori, Shiho Gotoh, Tomoko Yamashita, Ryota Uozumi, Yuya Kawabe, Dieter Edbauer

J Biol Chem· October 2021

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Clinico-genetic findings in 509 frontotemporal dementia patients.
Matias Wagner, Georg Lorenz, Alexander E Volk, Theresa Brunet, Dieter Edbauer

Mol Psychiatry· October 2021

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