Publications by authors named "Dimitry Ofengeim"

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Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T-cell-mediated cytotoxicity.
Syed Ali Raza, Yoshimi Enose-Akahata, Anna Blazier, Lauren M Guerra, Erin S Beck, Dimitry Ofengeim

Res Sq· September 2025

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Uncovering New Therapeutic Targets for Amyotrophic Lateral Sclerosis and Neurological Diseases Using Real-World Data.
Mohammadali Alidoost, Jeremy Y Huang, Georgia Dermentzaki, Anna S Blazier, Giorgio Gaglia, Dimitry Ofengeim

Clin Pharmacol Ther· July 2025

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Maintenance of chronic neuroinflammation in multiple sclerosis via interferon signaling and CD8 T cell-mediated cytotoxicity.
Syed Ali Raza, Yoshimi Enose-Akahata, Anna Blazier, Lauren M Guerra, Erin S Beck, Dimitry Ofengeim

bioRxiv· June 2025

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Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis.
Matija Zelic, Anna Blazier, Fabrizio Pontarelli, Michael LaMorte, Jeremy Huang, Dimitry Ofengeim

Immunity· April 2025

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Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.
Ali Rezaei, Virág Kocsis-Jutka, Zeynep I Gunes, Qing Zeng, Georg Kislinger, Dimitry Ofengeim

Nat Commun· April 2025

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BTK regulates microglial function and neuroinflammation in human stem cell models and mouse models of multiple sclerosis.
Ross C Gruber, Gregory S Wirak, Anna S Blazier, Lan Lee, Michael R Dufault, Dimitry Ofengeim

Nat Commun· November 2024

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Glucosylceramide synthase modulation ameliorates murine renal pathologies and promotes macrophage effector function in vitro.
Agnes Cheong, Florin Craciun, Hervé Husson, Joseph Gans, Javier Escobedo, Dimitry Ofengeim

Commun Biol· August 2024

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Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.
Zhaohui Du, Samuel Lessard, Tejaswi Iyyanki, Michael Chao, Timothy Hammond, Dimitry Ofengeim

HGG Adv· July 2024

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Comparative CNS Pharmacology of the Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib Versus Other BTK Inhibitor Candidates for Treating Multiple Sclerosis.
Timothy J Turner, Pricilla Brun, Ross C Gruber, Dimitry Ofengeim

Drugs R D· June 2024

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A guide to cell death pathways.
Junying Yuan, Dimitry Ofengeim

Nat Rev Mol Cell Biol· May 2024

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Safety, pharmacokinetics, and target engagement of a brain penetrant RIPK1 inhibitor, SAR443820 (DNL788), in healthy adult participants.
Agnes Hincelin-Mery, Xavier Nicolas, Cathy Cantalloube, Robert Pomponio, Pascale Lewanczyk, Dimitry Ofengeim

Clin Transl Sci· January 2024

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Protocol for establishing a global ischemia model using a 4-vessel occlusion in rats.
Hyunha Kim, Rachael Urquhart, Fabrizio Pontarelli, Teresa Jover-Mengual, Dimitry Ofengeim

STAR Protoc· December 2023

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Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dimitry Ofengeim

Cell Death Differ· May 2023

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Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration.
Sean K Ryan, Matija Zelic, Yingnan Han, Erin Teeple, Luoman Chen, Dimitry Ofengeim

Nat Neurosci· January 2023

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The SARS-CoV-2 main protease M causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Jan Wenzel, Josephine Lampe, Helge Müller-Fielitz, Raphael Schuster, Marietta Zille, Dimitry Ofengeim

Nat Neurosci· November 2021

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RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis.
Matija Zelic, Fabrizio Pontarelli, Lisa Woodworth, Cheng Zhu, Amy Mahan, Dimitry Ofengeim

Cell Rep· May 2021

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Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Mehrnoosh Jafari, Adrian-Minh Schumacher, Nicolas Snaidero, Emily M Ullrich Gavilanes, Tradite Neziraj, Dimitry Ofengeim

Nat Neurosci· March 2021

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CSF1R signaling is a regulator of pathogenesis in progressive MS.
Nellwyn Hagan, John L Kane, Deepak Grover, Lisa Woodworth, Charlotte Madore, Dimitry Ofengeim

Cell Death Dis· October 2020

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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.
Lauren Mifflin, Dimitry Ofengeim, Junying Yuan

Nat Rev Drug Discov· August 2020

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ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Zhenyi Su, Slawomir A Dziedzic, Die Hu, Vica Jean Barrett, Nicole Broekema, Dimitry Ofengeim

Cell Death Differ· June 2019

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Targeting RIPK1 for the treatment of human diseases.
Alexei Degterev, Dimitry Ofengeim, Junying Yuan

Proc Natl Acad Sci U S A· May 2019

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Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases.
Junying Yuan, Palak Amin, Dimitry Ofengeim

Nat Rev Neurosci· January 2019

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim

Cell· September 2018

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Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis.
Palak Amin, Marcus Florez, Ayaz Najafov, Heling Pan, Jiefei Geng, Dimitry Ofengeim

Proc Natl Acad Sci U S A· June 2018

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Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD.
Hongbo Chen, Mark W Kankel, Susan C Su, Steve W S Han, Dimitry Ofengeim

Cell Death Differ· March 2018

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