Publications by authors named "Dominic James"

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The human experience of comprehending source code in virtual reality.
James Dominic, Brock Tubre, Deborah Kunkel, Paige Rodeghero

Empir Softw Eng· September 2022

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Regulation of ALT-associated homology-directed repair by polyADP-ribosylation.
Song My Hoang, Nicole Kaminski, Ragini Bhargava, Jonathan Barroso-González, Michelle L Lynskey, Dominic I James

Nat Struct Mol Biol· December 2020

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Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells.
Manqi Zhang, Yanhao Lai, Judy L Vasquez, Dominic I James, Kate M Smith

Sci Rep· March 2020

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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer.
Aditi Jain, Lebaron C Agostini, Grace A McCarthy, Saswati N Chand, AnnJosette Ramirez, Dominic I James

Cancer Res· September 2019

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Ewa Gogola, Alexandra A Duarte, Julian R de Ruiter, Wouter W Wiegant, Jonas A Schmid, Dominic I James

Cancer Cell· June 2019

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors.
Nisha Pillay, Anthony Tighe, Louisa Nelson, Samantha Littler, Camilla Coulson-Gilmer, Dominic I James

Cancer Cell· March 2019

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Ben Acton, Helen F Small, Kate M Smith, Alison McGonagle, Alexandra I J Stowell, Dominic I James, James R Hitchin

Bioorg Med Chem Lett· February 2019

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
Bohdan Waszkowycz, Kate M Smith, Alison E McGonagle, Allan M Jordan, Ben Acton, James R Hitchin, Dominic I James

J Med Chem· December 2018

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Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.
Ewa Gogola, Alexandra A Duarte, Julian R de Ruiter, Wouter W Wiegant, Jonas A Schmid, Dominic I James

Cancer Cell· June 2018

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Studying Catabolism of Protein ADP-Ribosylation.
Luca Palazzo, Dominic I James, Ian D Waddell, Ivan Ahel

Methods Mol Biol· April 2018

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Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.
Polly Gravells, James Neale, Emma Grant, Amit Nathubhai, Kate M Smith, Dominic I James

DNA Repair (Amst)· January 2018

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Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase.
Polly Gravells, Emma Grant, Kate M Smith, Dominic I James, Helen E Bryant

DNA Repair (Amst)· April 2017

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
Dominic I James, Kate M Smith, Allan M Jordan, Emma E Fairweather, Louise A Griffiths, James R Hitchin

ACS Chem Biol· November 2016

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A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase.
Alexandra I J Stowell, Dominic I James, Ian D Waddell, Neil Bennett, Caroline Truman

Anal Biochem· June 2016

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: An R package for the dose response analysis of live cell imaging data.
Philip J Chapman, Dominic I James, Amanda J Watson, Gemma V Hopkins, Ian D Waddell

F1000Res· May 2016

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An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.
Dominic I James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A Griffiths

F1000Res· April 2016

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Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
Niall M Hamilton, Martin Dawson, Emma E Fairweather, Nicola S Hamilton, James R Hitchin, Dominic I James

J Med Chem· May 2012

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The development of an immunohistochemical method to detect the autophagy-associated protein LC3-II in human tumor xenografts.
Sarah V Holt, Beata Wyspianska, Kevin J Randall, Dominic James, John R Foster

Toxicol Pathol· April 2011

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Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.
Julien Ackermann, Garry Ashton, Steve Lyons, Dominic James, Jean-Pierre Hornung

PLoS One· April 2011

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Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells.
Patrizia Sini, Dominic James, Christine Chresta, Sylvie Guichard

Autophagy· May 2010

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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
Christine M Chresta, Barry R Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Dominic James

Cancer Res· January 2010

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Mitochondrial dynamics and apoptosis: a painful separation.
Dominic I James, Jean-Claude Martinou

Dev Cell· September 2008

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Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.
Philippe A Parone, Sandrine Da Cruz, Daniel Tondera, Yves Mattenberger, Dominic I James

PLoS One· September 2008

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Mechanisms of mitochondrial outer membrane permeabilization.
Dominic James, Philippe A Parone, Olivier Terradillos, Safa Lucken-Ardjomande, Sylvie Montessuit

Novartis Found Symp· January 2008

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Mitochondrial bioenergetics and structural network organization.
Giovanni Benard, Nadège Bellance, Dominic James, Philippe Parrone, Helder Fernandez

J Cell Sci· March 2007

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