Publications by authors named "Dominic Walsh"

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A manifesto for Alzheimer's disease drug discovery in the era of disease-modifying therapies.
Heike Hering, Thierry Bussiere, Chia-Chen Liu, Kelly E Glajch, Andreas Weihofen, Dominic M Walsh

Mol Neurodegener· August 2025

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Dominic M Walsh

Science· August 2025

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Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region.
Tomas Ondrejcak, Neng-Wei Hu, Emily Coode, Tom Campbell, Grant T Corbett, Dominic M Walsh

Acta Neuropathol· June 2025

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Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity.
Simin Song, Qianmin Liu, Ruixiang Chen, Ping Chen, Min Tao, Dominic M Walsh

Acta Neuropathol Commun· May 2025

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Patient-derived tau and amyloid-β facilitate long-term depression : role of tumour necrosis factor-α and the integrated stress response.
Neng-Wei Hu, Tomas Ondrejcak, Igor Klyubin, Yin Yang, Dominic M Walsh

Brain Commun· September 2024

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Two mouse models of Alzheimer's disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein.
Silvia A Purro, Michael Farmer, Elizabeth Noble, Claire J Sarell, Megan Powell, Dominic Walsh

PLoS One· November 2023

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Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation .
Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Dominic M Walsh

J Neurosci· August 2023

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Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Dominic M Walsh

Acta Neuropathol Commun· March 2023

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Methods for the isolation and analysis of Aβ from postmortem brain.
Wei Hong, Wen Liu, Alexandra O Desousa, Tracy Young-Pearse, Dominic M Walsh

Front Neurosci· January 2023

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NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression.
David Mengel, Tze How Mok, Akin Nihat, Wen Liu, Robert A Rissman, Dominic M Walsh

Cells· December 2021

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Laboratory evolution of a sortase enzyme that modifies amyloid-β protein.
Christopher J Podracky, Chihui An, Alexandra DeSousa, Brent M Dorr, Dominic M Walsh

Nat Chem Biol· March 2021

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Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease.
Niklas Mattsson-Carlgren, Shorena Janelidze, Sebastian Palmqvist, Nicholas Cullen, Anna L Svenningsson, Dominic M Walsh

Brain· December 2020

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Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease.
David Mengel, Shorena Janelidze, Robert J Glynn, Wen Liu, Oskar Hansson, Dominic M Walsh

Ann Neurol· November 2020

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Amyloid β-protein and beyond: the path forward in Alzheimer's disease.
Dominic M Walsh, Dennis J Selkoe

Curr Opin Neurobiol· April 2020

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PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Dominic M Walsh

Acta Neuropathol· March 2020

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Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase.
David Mengel, Wen Liu, Robert J Glynn, Dennis J Selkoe, Andre Strydom, Dominic M Walsh

Alzheimers Res Ther· March 2020

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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients.
Diana J Cha, David Mengel, Maja Mustapic, Wen Liu, Dennis J Selkoe, Dominic M Walsh

Front Neurosci· November 2019

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Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.
Ting Yang, Yifan Dang, Beth Ostaszewski, David Mengel, Verena Steffen, Dominic M Walsh

Ann Neurol· August 2019

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A vicious cycle of β amyloid-dependent neuronal hyperactivation.
Benedikt Zott, Manuel M Simon, Wei Hong, Felix Unger, Hsing-Jung Chen-Engerer, Dominic M Walsh

Science· August 2019

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Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo.
Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T Corbett, Dominic M Walsh

Neurobiol Dis· July 2019

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PrP-grafted antibodies bind certain amyloid β-protein aggregates, but do not prevent toxicity.
David Mengel, Wei Hong, Grant T Corbett, Wen Liu, Alexandra DeSousa, Dominic M Walsh

Brain Res· May 2019

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Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.
Gunnar Brinkmalm, Wei Hong, Zemin Wang, Wen Liu, Tiernan T O'Malley, Dominic M Walsh

Brain· May 2019

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Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.
Zhicheng Chen, David Mengel, Ashvini Keshavan, Robert A Rissman, Andrew Billinton, Dominic M Walsh

Alzheimers Dement· March 2019

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Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau .
Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Dominic M Walsh

J Neurosci· December 2018

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Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.
Silvia A Purro, Mark A Farrow, Jacqueline Linehan, Tamsin Nazari, David X Thomas, Dominic M Walsh

Nature· December 2018

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