Publications by authors named "Dorothy Sims"

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Development and preclinical characterization of AMG 329: a human antibody neutralizing FLT3 ligand.
Annie Lau-Kilby, Michele Gunsior, Agata Bartczak, Susan Chyou, James Hester, Dorothy Sims

MAbs· December 2025

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FLT3L neutralization reduces dendritic cell numbers, T Cell activation, and salivary gland lymphocyte infiltration in the NOD.H2h4 Sjögren's mouse model.
Agata Bartczak, Dorothy Sims, Kamelia Zerrouki, Brian Naiman, Ariful Qadri

J Immunol· October 2025

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
Elizabeth England, D Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T Y Chan, Dorothy A Sims

Sci Rep· June 2023

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Characterization of Citrullination Sites in Neutrophils and Mast Cells Activated by Ionomycin via Integration of Mass Spectrometry and Machine Learning.
Raghothama Chaerkady, Yebin Zhou, Jared A Delmar, Shao Huan Samuel Weng, Junmin Wang, Dorothy Sims, Gary P Sims

J Proteome Res· June 2021

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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.
E Suzanne Cohen, Ian C Scott, Jayesh B Majithiya, Laura Rapley, Benjamin P Kemp, Dorothy A Sims

Nat Commun· September 2015

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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma.
E Suzanne Cohen, Claire L Dobson, Helena Käck, Bing Wang, Dorothy A Sims

MAbs· May 2015

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High-precision, high-throughput stability determinations facilitated by robotics and a semiautomated titrating fluorometer.
Marshall Hall Edgell, Dorothy A Sims, Gary J Pielak, Fang Yi

Biochemistry· June 2003

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Testing hypotheses about determinants of protein structure with high-precision, high-throughput stability measurements and statistical modeling.
Fang Yi, Dorothy A Sims, Gary J Pielak, Marshall Hall Edgell

Biochemistry· June 2003

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