Publications by authors named "Duncan Miller"

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Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts.
Jorge Ruiz-Orera, Duncan C Miller, Johannes Greiner, Carolin Genehr, Aliki Grammatikaki

Nat Cardiovasc Res· October 2024

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Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure.
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Duncan C Miller

Nat Commun· August 2024

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SRRM2 splicing factor modulates cell fate in early development.
Silvia Carvalho, Luna Zea-Redondo, Tsz Ching Chloe Tang, Philipp Stachel-Braum, Duncan Miller

Biol Open· April 2024

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GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.
Hidekazu Ishida, Rie Saba, Ioannis Kokkinopoulos, Masakazu Hashimoto, Osamu Yamaguchi, Duncan Miller

Cell Rep· November 2023

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Generation of an induced pluripotent stem cell line from a Huntington's disease patient with a long HTT-PolyQ sequence.
Duncan C Miller, Pawel Lisowski, Carolin Genehr, Erich E Wanker, Josef Priller

Stem Cell Res· April 2023

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Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Duncan C Miller, Suzannah J Harnor, Mathew P Martin, Richard A Noble, Stephen R Wedge

J Med Chem· April 2023

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Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.
Maria Ercu, Michael B Mücke, Tamara Pallien, Lajos Markó, Anastasiia Sholokh, Duncan C Miller

Circulation· December 2022

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Generation of induced pluripotent stem cells from three individuals with Huntington's disease.
Duncan C Miller, Pawel Lisowski, Selene Lickfett, Barbara Mlody, Miriam Bünning

Stem Cell Res· December 2022

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Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
Gemma Davison, Mathew P Martin, Shannon Turberville, Selma Dormen, Richard Heath, Duncan C Miller

J Med Chem· November 2022

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Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes.
Philipp Gmach, Marc Bathe-Peters, Narasimha Telugu, Duncan C Miller, Paolo Annibale

Int J Mol Sci· September 2022

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Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes.
Loukia Yiangou, Albert Blanch-Asensio, Tessa de Korte, Duncan C Miller, Berend J van Meer

Stem Cells· July 2022

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Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
Duncan C Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J Cook

J Med Chem· May 2022

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Retrogene Duplication and Expression Patterns Shaped by the Evolution of Sex Chromosomes in Malaria Mosquitoes.
Duncan Miller, Jianhai Chen, Jiangtao Liang, Esther Betrán, Manyuan Long

Genes (Basel)· May 2022

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Disruptors of AKAP-Dependent Protein-Protein Interactions.
Ryan Walker-Gray, Tamara Pallien, Duncan C Miller, Andreas Oder, Martin Neuenschwander

Methods Mol Biol· March 2022

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Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS).
Janine Cernoch, Tanja Fisch, Iris Fischer, Kristin Fischer, Anna Iwanska, Duncan Miller

Stem Cell Res· July 2021

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An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase.
Islam Al-Khawaldeh, Mohammed J Al Yasiri, Gregory G Aldred, Christine Basmadjian, Cinzia Bordoni, Duncan C Miller

J Med Chem· July 2021

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
Gianni Chessari, Ian R Hardcastle, Jong Sook Ahn, Burcu Anil, Elizabeth Anscombe, Duncan C Miller

J Med Chem· April 2021

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Simple Workflow and Comparison of Media for hPSC-Cardiomyocyte Cryopreservation and Recovery.
Duncan C Miller, Carolin Genehr, Narasimha S Telugu, Silke Kurths, Sebastian Diecke

Curr Protoc Stem Cell Biol· December 2020

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Methods for Automated Single Cell Isolation and Sub-Cloning of Human Pluripotent Stem Cells.
Valeria Fernandez Vallone, Narasimha Swamy Telugu, Iris Fischer, Duncan Miller, Sandra Schommer

Curr Protoc Stem Cell Biol· December 2020

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Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias.
Karina O Brandão, Lettine van den Brink, Duncan C Miller, Catarina Grandela, Berend J van Meer

Stem Cell Reports· November 2020

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Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Stephanie M Myers, Duncan C Miller, Lauren Molyneux, Mercedes Arasta, Ruth H Bawn

Eur J Med Chem· September 2019

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FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
Daniel J Wood, J Daniel Lopez-Fernandez, Leanne E Knight, Islam Al-Khawaldeh, Conghao Gai, Duncan C Miller

J Med Chem· April 2019

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The discovery and optimization of benzimidazoles as selective Na1.8 blockers for the treatment of pain.
Alan D Brown, Sharan K Bagal, Paul Blackwell, David C Blakemore, Bruce Brown, Duncan Miller

Bioorg Med Chem· January 2019

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.
Duncan C Miller, Mathew P Martin, Santosh Adhikari, Alfie Brennan, Jane A Endicott

Org Biomol Chem· March 2018

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Ajmaline blocks I and I without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters.
Duncan C Miller, Stephen C Harmer, Ariel Poliandri, Muriel Nobles, Elizabeth C Edwards

Stem Cell Res· December 2017

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