Publications by authors named "Edward Garvey"

Claim this Profile
S
Safety and pharmacokinetics of antifungal agent VT-1598 and its primary metabolite, VT-11134, in healthy adult subjects: phase 1, first-in-human, randomized, double-blind, placebo-controlled study of single-ascending oral doses of VT-1598.
Kenan Gu, Robert Spitz, Erin Hammett, Anna Jaunarajs, Varduhi Ghazaryan, Edward P Garvey

Med Mycol· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
FDA Public Workshop Summary-Coccidioidomycosis (Valley Fever): Considerations for Development of Antifungal Drugs.
Elizabeth O'Shaughnessy, Yuliya Yasinskaya, Cheryl Dixon, Karen Higgins, Jason Moore, Edward Garvey

Clin Infect Dis· June 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.
Andrew T Nishimoto, Sarah G Whaley, Nathan P Wiederhold, Qing Zhang, Christopher M Yates, Edward P Garvey

Antimicrob Agents Chemother· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of .
Andrew T Nishimoto, Nathan P Wiederhold, Stephanie A Flowers, Qing Zhang, Steven L Kelly, Edward P Garvey

Antimicrob Agents Chemother· June 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates and Activity against Candida auris.
Nathan P Wiederhold, Shawn R Lockhart, Laura K Najvar, Elizabeth L Berkow, Rosie Jaramillo, Edward P Garvey

Antimicrob Agents Chemother· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues.
Binto Simon, Claire Walmsley, Victoria J Jackson, Edward P Garvey, Martin J Slater

Bioorg Med Chem Lett· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
Nathan P Wiederhold, Xin Xu, Amy Wang, Laura K Najvar, Edward P Garvey

Antimicrob Agents Chemother· November 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.
Nathan P Wiederhold, Laura K Najvar, Edward P Garvey, Stephen R Brand, Xin Xu

Antimicrob Agents Chemother· September 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.
Timothy J Break, Jigar V Desai, Kelley R Healey, Mukil Natarajan, Elise M N Ferre, Edward P Garvey

J Antimicrob Chemother· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.
Nathan P Wiederhold, Lisa F Shubitz, Laura K Najvar, Rosie Jaramillo, Marcos Olivo, Edward P Garvey

Antimicrob Agents Chemother· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
Fungal-specific Cyp51 inhibitor VT-1598 demonstrates in vitro activity against Candida and Cryptococcus species, endemic fungi, including Coccidioides species, Aspergillus species and Rhizopus arrhizus.
Nathan P Wiederhold, Hoja P Patterson, Bich Hue Tran, Christopher M Yates, Robert J Schotzinger, Edward P Garvey

J Antimicrob Chemother· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans.
Timothy J Break, Jigar V Desai, Mukil Natarajan, Elise M N Ferre, Christina Henderson, Edward P Garvey

J Antimicrob Chemother· January 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Teclegiorgis Gebremariam, Sondus Alkhazraji, Lin Lin, Nathan P Wiederhold, Edward P Garvey

Antimicrob Agents Chemother· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors.
Christopher M Yates, Edward P Garvey, Sammy R Shaver, Robert J Schotzinger, William J Hoekstra

Bioorg Med Chem Lett· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Tatiana Y Hargrove, Edward P Garvey, William J Hoekstra, Christopher M Yates, Zdzislaw Wawrzak

Antimicrob Agents Chemother· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.
Andrew G S Warrilow, Josie E Parker, Claire L Price, Edward P Garvey, William J Hoekstra

Antimicrob Agents Chemother· July 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Activity of VT-1129 against Cryptococcus neoformans clinical isolates with high fluconazole MICs.
Kirsten Nielsen, Priya Vedula, Kyle D Smith, David B Meya, Edward P Garvey

Med Mycol· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficacy of the Investigational Antifungal VT-1161 in Treating Naturally Occurring Coccidioidomycosis in Dogs.
Lisa F Shubitz, Michael E Roy, Hien T Trinh, William J Hoekstra, Robert J Schotzinger, Edward P Garvey

Antimicrob Agents Chemother· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
Andrew G S Warrilow, Josie E Parker, Claire L Price, W David Nes, Edward P Garvey

Antimicrob Agents Chemother· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii.
Shawn R Lockhart, Annette W Fothergill, Naureen Iqbal, Carol B Bolden, Nina T Grossman, Edward P Garvey

Antimicrob Agents Chemother· April 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of VT-1161 for Treatment of Coccidioidomycosis in Murine Infection Models.
Lisa F Shubitz, Hien T Trinh, John N Galgiani, Maria L Lewis, Annette W Fothergill, Edward P Garvey

Antimicrob Agents Chemother· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
V
VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
Teclegiorgis Gebremariam, Nathan P Wiederhold, Annette W Fothergill, Edward P Garvey, William J Hoekstra

Antimicrob Agents Chemother· December 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antiviral characteristics of GSK1265744, an HIV integrase inhibitor dosed orally or by long-acting injection.
Tomokazu Yoshinaga, Masanori Kobayashi, Takahiro Seki, Shigeru Miki, Chiaki Wakasa-Morimoto, Edward P Garvey

Antimicrob Agents Chemother· January 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and optimization of highly-selective fungal CYP51 inhibitors.
William J Hoekstra, Edward P Garvey, William R Moore, Stephen W Rafferty, Christopher M Yates

Bioorg Med Chem Lett· August 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups.
Brian A Johns, Takashi Kawasuji, Jason G Weatherhead, Eric E Boros, James B Thompson, Edward P Garvey

Bioorg Med Chem Lett· July 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis