Publications by authors named "Edward Meek"

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Model acetylcholinesterase-Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure.
Thomas G Biel, Talia Faison, Alicia M Matthews, Uriel Ortega-Rodriguez, Vincent M Falkowski, Edward Meek

Bioeng Transl Med· September 2024

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Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates.
Joshua P Bennett, Edward C Meek, Janice E Chambers

J Biochem Mol Toxicol· July 2024

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The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases.
Sohaib Habiballah, Janice Chambers, Edward Meek, Brad Reisfeld

J Comput Aided Mol Des· December 2023

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Alterations of Systemic and Hepatic Metabolic Function Following Exposure to Trans-nonachlor in Low and High Fat Diet Fed Male Sprague Dawley Rats.
Erin McDevitt, Lucie Henein, Anna Crawford, Sandeep Kondakala, Darian Young, Edward Meek

Int J Toxicol· November 2023

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The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases.
Sohaib Habiballah, Janice Chambers, Edward Meek, Brad Reisfeld

Res Sq· July 2023

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Pharmacokinetics of three novel pyridinium aldoxime acetylcholinesterase reactivators in female rats.
Brian S Backer, Edward C Meek, Matthew K Ross, Janice E Chambers

Toxicol Appl Pharmacol· July 2022

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Inhibition Kinetics of 16 Organophosphorus Pesticides or Their Active Metabolites on Erythrocyte Acetylcholinesterase From Humans and Rats.
Edward C Meek, Richard Reiss, John Allen Crow, Janice E Chambers

Toxicol Sci· September 2021

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In vitro age-related differences in rats to organophosphates.
Edward C Meek, Russell L Carr, Janice E Chambers

Toxicol In Vitro· April 2021

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Novel pyridinium oximes enhance 24-h survivability against a lethal dose of nerve agent surrogate in adult female rats.
Jason M Garcia, Edward C Meek, Janice E Chambers

Toxicology· December 2020

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Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.
Janice E Chambers, Edward C Meek

Ann N Y Acad Sci· November 2020

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Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.
Janice E Chambers, Mary B Dail, Edward C Meek

Neuropharmacology· September 2020

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Association of serum levels of - Dichlorodiphenyldichloroethylene (DDE) with type 2 diabetes in African American and Caucasian adult men from agricultural (Delta) and non-agricultural (non-Delta) regions of Mississippi.
Edward C Meek, Dana Dale Jones, J Allen Crow, Robert W Wills, William H Cooke

J Toxicol Environ Health A· May 2020

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Novel centrally active oxime reactivators of acetylcholinesterase inhibited by surrogates of sarin and VX.
Janice E Chambers, Edward C Meek

Neurobiol Dis· January 2020

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In vitro P-glycoprotein activity does not completely explain in vivo efficacy of novel centrally effective oxime acetylcholinesterase reactivators.
Mary Beth Dail, Edward Caldwell Meek, Howard Wayne Chambers, Janice Elaine Chambers

Drug Chem Toxicol· July 2019

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Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus.
Mary B Dail, Charles A Leach, Edward C Meek, Alicia K Olivier, Ronald B Pringle

Toxicol Sci· June 2019

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Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain.
Ronald B Pringle, Edward C Meek, Howard W Chambers, Janice E Chambers

Toxicol Sci· December 2018

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A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.
J Allen Crow, Edward C Meek, Robert W Wills, Janice E Chambers

Diabetes Metab Res Rev· March 2018

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Effects of Chlorpyrifos or Methyl Parathion on Regional Cholinesterase Activity and Muscarinic Receptor Subtype Binding in Juvenile Rat Brain.
Shirley X Guo-Ross, Edward C Meek, Janice E Chambers, Russell L Carr

J Toxicol Pharmacol· December 2017

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Association of type 2 diabetes mellitus with plasma organochlorine compound concentrations.
Paul R Eden, Edward C Meek, Robert W Wills, Eric V Olsen, J Allen Crow

J Expo Sci Environ Epidemiol· December 2016

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Efficacy of novel phenoxyalkyl pyridinium oximes as brain-penetrating reactivators of cholinesterase inhibited by surrogates of sarin and VX.
Janice E Chambers, Howard W Chambers, Kristen E Funck, Edward C Meek, Ronald B Pringle

Chem Biol Interact· November 2016

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The association of serum trans-nonachlor levels with atherosclerosis.
Lee C Mangum, Lauren H Mangum, Janice E Chambers, Matthew K Ross, Edward C Meek

J Toxicol Environ Health A· August 2016

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Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates.
Janice E Chambers, Edward C Meek, Howard W Chambers

Ann N Y Acad Sci· June 2016

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Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates.
Janice E Chambers, Edward C Meek, Joshua P Bennett, W Shane Bennett, Howard W Chambers

Toxicology· January 2016

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The effect of PON1 enhancers on reducing acetylcholinesterase inhibition following organophosphate anticholinesterase exposure in rats.
Edward C Meek, Howard W Chambers, Ronald B Pringle, Janice E Chambers

Toxicology· October 2015

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Effect of chronic p,p'-dichlorodiphenyldichloroethylene (DDE) exposure on high fat diet-induced alterations in glucose and lipid metabolism in male C57BL/6H mice.
George E Howell, Charlee Mulligan, Edward Meek, Janice E Chambers

Toxicology· February 2015

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