Publications by authors named "Edward Ruediger"

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Medicinal Chemistry and NMR Driven Discovery of Novel UDP-glucuronosyltransferase 1A Inhibitors That Overcome Therapeutic Resistance in Cells.
Michael J Osborne, Anamika Sulekha, Biljana Culjkovic-Kraljacic, Jadwiga Gasiorek, Edward Ruediger

J Mol Biol· January 2024

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Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
E Scott Priestley, Jacques Banville, Daniel Deon, Laurence Dubé, Marc Gagnon, Edward Ruediger

J Med Chem· July 2022

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Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.
Jacynthe L Toulouse, Genbin Shi, Claudèle Lemay-St-Denis, Maximilian C C J C Ebert, Daniel Deon, Edward Ruediger

ACS Med Chem Lett· November 2020

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Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
Michael M Miller, Jacques Banville, Todd J Friends, Mark Gagnon, Jon J Hangeland, Edward Ruediger

J Med Chem· August 2019

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Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
Jacynthe L Toulouse, Brahm J Yachnin, Edward H Ruediger, Daniel Deon, Marc Gagnon

ACS Omega· June 2019

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Monomer-to-dimer transition of Brucella suis type IV secretion system component VirB8 induces conformational changes.
Mahzad Sharifahmadian, Tarun Arya, Benoit Bessette, Lauriane Lecoq, Edward Ruediger

FEBS J· April 2017

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Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.
Makonen Belema, Van N Nguyen, Carol Bachand, Dan H Deon, Jason T Goodrich, Edward H Ruediger

J Med Chem· March 2014

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The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.
Dike Qiu, Julie A Lemm, Donald R O'Boyle, Jin-Hua Sun, Peter T Nower, Edward Ruediger

J Gen Virol· November 2011

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New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Harold Mastalerz, Ming Chang, Ping Chen, Pierre Dextraze, Brian E Fink, Edward Ruediger

Bioorg Med Chem Lett· April 2007

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Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.
Francis Beaulieu, Carl Ouellet, Edward H Ruediger, Makonen Belema, Yuping Qiu

Bioorg Med Chem Lett· March 2007

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Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
Mark G Saulnier, Balu N Balasubramanian, Byron H Long, David B Frennesson, Edward Ruediger

J Med Chem· April 2005

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Novel 3',6'-anhydro and N12,N13-bridged glycosylated fluoroindolo[2,3-a]carbazoles as topoisomerase I inhibitors. Fluorine as a leaving group from sp3 carbon.
Mark G Saulnier, David R Langley, David B Frennesson, Byron H Long, Stella Huang, Edward Ruediger

Org Lett· March 2005

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Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
Balu N Balasubramanian, Denis R St Laurent, Mark G Saulnier, Byron H Long, Carol Bachand, Edward Ruediger

J Med Chem· March 2004

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beta-alanine dipeptides as MC4R agonists.
Réjean Ruel, Timothy F Herpin, Lawrence Iben, Guanglin Luo, Alain Martel, Edward H Ruediger

Bioorg Med Chem Lett· December 2003

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2-arylaminothiazoles as high-affinity corticotropin-releasing factor 1 receptor (CRF1R) antagonists: synthesis, binding studies and behavioral efficacy.
Gene M Dubowchik, Jodi A Michne, Dmitry Zuev, Wendy Schwartz, Paul M Scola, Edward H Ruediger

Bioorg Med Chem Lett· November 2003

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