Publications by authors named "Lawrence Iben"

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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.
Alan S Robertson, Lawrence G Iben, Cong Wei, Jere E Meredith, Dieter M Drexler

Eur J Pharmacol· October 2017

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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Jeremy H Toyn, Lorin A Thompson, Kimberley A Lentz, Jere E Meredith, Catherine R Burton, Lawrence G Iben

Int J Alzheimers Dis· August 2014

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Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.
Guanglin Luo, Ling Chen, Shuanghua Hu, Yazhong Huang, Gail Mattson, Lawrence G Iben

Bioorg Med Chem Lett· July 2013

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Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
Samuel W Gerritz, Weixu Zhai, Shuhao Shi, Shirong Zhu, Jeremy H Toyn, Lawrence G Iben

J Med Chem· November 2012

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Discovery of a Novel Class of Bicyclo[3.1.0]hexanylpiperazines as Noncompetitive Neuropeptide Y Y1 Antagonists.
Shuanghua Hu, Yazhong Huang, Milind Deshpande, Guanglin Luo, Marc A Bruce, Lawrence G Iben

ACS Med Chem Lett· March 2012

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[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
Lawrence G Iben, Lisa Kopcho, Jovita Marcinkeviciene, Changsheng Zheng, Lorin A Thompson

Eur J Pharmacol· September 2008

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P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Jere E Meredith, Lorin A Thompson, Jeremy H Toyn, Lawrence Marcin, Donna M Barten, Lawrence Iben

J Pharmacol Exp Ther· August 2008

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Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y(1) receptor antagonist.
Ildiko Antal-Zimanyi, Marc A Bruce, Karen L Leboulluec, Lawrence G Iben, Gail K Mattson

Eur J Pharmacol· August 2008

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The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
Catherine R Burton, Jere E Meredith, Donna M Barten, Margi E Goldstein, Carol M Krause, Lawrence G Iben

J Biol Chem· August 2008

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Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.
Lawrence G Iben, Richard E Olson, Lynn A Balanda, Sukhanya Jayachandra, Barbara J Robertson

J Biol Chem· December 2007

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Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.
Margi E Goldstein, Yang Cao, Tracey Fiedler, Jeremy Toyn, Lawrence Iben

J Pharmacol Exp Ther· October 2007

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Synthesis and evaluation of 5,5-diphenylimidazolones as potent human neuropeptide Y5 receptor antagonists.
Kevin W Gillman, Mendi A Higgins, Graham S Poindexter, Marc Browning, Wendy J Clarke, Lawrence G Iben

Bioorg Med Chem· August 2006

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(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.
Li-Qiang Sun, Katherine Takaki, Jie Chen, Stephen Bertenshaw, Lawrence Iben

Bioorg Med Chem Lett· March 2005

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Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists.
George N Karageorge, Stephen Bertenshaw, Lawrence Iben, Cen Xu, Nathan Sarbin

Bioorg Med Chem Lett· December 2004

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N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist.
Li-Qiang Sun, Katherine Takaki, Jie Chen, Lawrence Iben, Jay O Knipe

Bioorg Med Chem Lett· October 2004

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Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity.
Kenneth M Boy, Michael Dee, Joseph Yevich, John Torrente, Qi Gao, Lawrence Iben

Bioorg Med Chem Lett· September 2004

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Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.
Li-Qiang Sun, Jie Chen, Marc Bruce, Jeffrey A Deskus, James R Epperson, Lawrence Iben

Bioorg Med Chem Lett· July 2004

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Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands.
Li-Qiang Sun, Jie Chen, Katherine Takaki, Graham Johnson, Lawrence Iben

Bioorg Med Chem Lett· March 2004

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4-Substituted anilides as selective melatonin MT2 receptor agonists.
James R Epperson, Jeffrey A Deskus, Anthony J Gentile, Lawrence G Iben, Elaine Ryan

Bioorg Med Chem Lett· February 2004

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beta-alanine dipeptides as MC4R agonists.
Réjean Ruel, Timothy F Herpin, Lawrence Iben, Guanglin Luo, Alain Martel

Bioorg Med Chem Lett· December 2003

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Heterocyclic aminopyrrolidine derivatives as melatoninergic agents.
Li-Qiang Sun, Jie Chen, Ronald J Mattson, James R Epperson, Jeffrey A Deskus, Lawrence Iben

Bioorg Med Chem Lett· December 2003

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Differentially functionalized diamines as novel ligands for the NPY2 receptor.
Charles J Andres, Ildiko Antal Zimanyi, Milind S Deshpande, Lawrence G Iben, Katharine Grant-Young

Bioorg Med Chem Lett· September 2003

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Indanyl piperazines as melatonergic MT2 selective agents.
Ronald J Mattson, John D Catt, Daniel Keavy, Charles P Sloan, James Epperson, Lawrence Iben

Bioorg Med Chem Lett· March 2003

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