Publications by authors named "Jeremy Toyn"

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Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.
Yunhui Zhang, Kenneth M Boy, Yong-Jin Wu, Antonio Ramirez, Jeremy H Toyn

Bioorg Med Chem Lett· November 2020

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Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481.
Kenneth M Boy, Jason M Guernon, Dmitry S Zuev, Li Xu, Yunhui Zhang, Jeremy H Toyn

ACS Med Chem Lett· March 2019

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Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.
Alan S Robertson, Lawrence G Iben, Cong Wei, Jere E Meredith, Dieter M Drexler, Jeremy H Toyn

Eur J Pharmacol· October 2017

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Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors.
Yong-Jin Wu, Jason Guernon, Ramkumar Rajamani, Jeremy H Toyn, Michael K Ahlijanian

Bioorg Med Chem Lett· December 2016

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Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
Yong-Jin Wu, Jason Guernon, Jianliang Shi, Lawrence Marcin, Mendi Higgins, Jeremy H Toyn

J Med Chem· September 2016

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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.
Holly D Soares, Maciej Gasior, Jeremy H Toyn, Jun-Sheng Wang, Quan Hong

J Pharmacol Exp Ther· July 2016

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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
Jeremy H Toyn, Kenneth M Boy, Joseph Raybon, Jere E Meredith, Alan S Robertson

J Pharmacol Exp Ther· July 2016

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Design and optimization of tricyclic gamma-secretase modulators.
Jianliang Shi, Dmitry Zuev, Li Xu, Kimberley A Lentz, James E Grace, Jeremy H Toyn

Bioorg Med Chem Lett· March 2016

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Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators.
Yong-Jin Wu, Yunhui Zhang, Jeremy H Toyn, John E Macor, Lorin A Thompson

Bioorg Med Chem Lett· March 2016

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Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.
Yong-Jin Wu, Jason Guernon, Fukang Yang, Lawrence Snyder, Jianliang Shi, Jeremy H Toyn

ACS Med Chem Lett· March 2016

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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE).
Kenneth M Boy, Jason M Guernon, Yong-Jin Wu, Yunhui Zhang, Joe Shi, Jeremy H Toyn

Bioorg Med Chem Lett· November 2015

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What lessons can be learned from failed Alzheimer's disease trials?
Jeremy Toyn

Expert Rev Clin Pharmacol· May 2015

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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Jeremy H Toyn, Lorin A Thompson, Kimberley A Lentz, Jere E Meredith, Catherine R Burton

Int J Alzheimers Dis· August 2014

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Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.
Jeremy H Toyn, Michael K Ahlijanian

Alzheimers Res Ther· July 2014

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γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
Jeremy H Toyn, Adele Rowley, Yasuji Matsuoka, Taisuke Tomita, Bruno P Imbimbo

Int J Alzheimers Dis· May 2013

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Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
Charles F Albright, Randy C Dockens, Jere E Meredith, Richard E Olson, Randy Slemmon, Jeremy H Toyn

J Pharmacol Exp Ther· March 2013

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Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
Samuel W Gerritz, Weixu Zhai, Shuhao Shi, Shirong Zhu, Jeremy H Toyn

J Med Chem· November 2012

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Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).
Kenneth M Boy, Jason M Guernon, Jianliang Shi, Jeremy H Toyn, Jere E Meredith

Bioorg Med Chem Lett· November 2011

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Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.
Lorin A Thompson, Jianliang Shi, Carl P Decicco, Andrew J Tebben, Richard E Olson, Jeremy H Toyn

Bioorg Med Chem Lett· November 2011

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Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.
Lawrence R Marcin, Mendi A Higgins, F Christopher Zusi, Yunhui Zhang, Michael F Dee, Jeremy H Toyn

Bioorg Med Chem Lett· January 2011

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Viable mouse gene ablations that robustly alter brain Aβ levels are rare.
Jeremy H Toyn, Xu-Alan Lin, Mark W Thompson, Valerie Guss, Jere E Meredith

BMC Neurosci· November 2010

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Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
Kevin W Gillman, John E Starrett, Michael F Parker, Kai Xie, Joanne J Bronson, Jeremy H Toyn

ACS Med Chem Lett· June 2010

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Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.
Joseph L Cantone, Alan Xu-Lin, Jeremy H Toyn, Dieter M Drexler

J Neurosci Methods· June 2009

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Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.
Yong-Jin Wu, Yunhui Zhang, Andrew C Good, Catherine R Burton, Jeremy H Toyn

Bioorg Med Chem Lett· May 2009

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[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.
Lawrence G Iben, Lisa Kopcho, Jovita Marcinkeviciene, Changsheng Zheng, Lorin A Thompson, Jeremy H Toyn

Eur J Pharmacol· September 2008

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