Publications by authors named "Joseph Raybon"

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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R Beno, Kyle Parcella, John A Bender, Katherine A Grant-Young, Joseph Raybon

J Med Chem· May 2017

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Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression.
Andrew P Degnan, George O Tora, Hong Huang, David A Conlon, Carl D Davis, Joseph Raybon

ACS Chem Neurosci· December 2016

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The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.
Holly D Soares, Maciej Gasior, Jeremy H Toyn, Jun-Sheng Wang, Quan Hong, Joseph Raybon

J Pharmacol Exp Ther· July 2016

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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
Jeremy H Toyn, Kenneth M Boy, Joseph Raybon, Jere E Meredith, Alan S Robertson

J Pharmacol Exp Ther· July 2016

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Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
Guanglin Luo, Ling Chen, Catherine R Burton, Hong Xiao, Prasanna Sivaprakasam, Joseph Raybon

J Med Chem· February 2016

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Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape.
Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, Valeriu Damian-Iordache, Christopher Gibson, Joseph Raybon

AAPS J· March 2015

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Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.
Jeremy H Toyn, Lorin A Thompson, Kimberley A Lentz, Jere E Meredith, Catherine R Burton, Joseph Raybon

Int J Alzheimers Dis· August 2014

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Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
Charles F Albright, Randy C Dockens, Jere E Meredith, Richard E Olson, Randy Slemmon, Joseph J Raybon

J Pharmacol Exp Ther· March 2013

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Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice.
Joseph J Raybon, Devin Pray, Daniel G Morgan, Mary Zoeckler, Ming Zheng

J Pharmacol Exp Ther· April 2011

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In response to "a gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system".
Joseph J Raybon, Charles F Albright

Ann Neurol· January 2010

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Pharmacokinetics and pharmacodynamics of gamma-hydroxybutyric acid during tolerance in rats: effects on extracellular dopamine.
Joseph J Raybon, Kathleen M K Boje

J Pharmacol Exp Ther· March 2007

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Alterations in neuronal transport but not blood-brain barrier transport are observed during gamma-hydroxybutyrate (GHB) sedative/hypnotic tolerance.
Indranil Bhattacharya, Joseph J Raybon, Kathleen M K Boje

Pharm Res· September 2006

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Liquid chromatographic-mass spectrometric determination of endogenous gamma-hydroxybutyrate concentrations in rat brain regions and plasma.
Ho-Leung Fung, Eric Haas, Joseph Raybon, Jian Xu, Sun-Mi Fung

J Chromatogr B Analyt Technol Biomed Life Sci· August 2004

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Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins.
Kathleen M K Boje, David Jaworowicz, Joseph J Raybon

J Pharmacol Exp Ther· January 2003

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