Publications by authors named "Edwin Iwanowicz"

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Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax.
Sabrina C D Daglish, Owen G Canterbury, Paul R Graves, Sarah A Carter, Sydney M Beese, Edwin J Iwanowicz

Res Sq· November 2025

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TR-107, an Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells.
Michael Giarrizzo, Joseph F LaComb, Hetvi R Patel, Rohan G Reddy, John D Haley, Edwin J Iwanowicz

Mol Cancer Ther· December 2024

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The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells .
Narjis Fatima, Yandong Shen, Kyle Crassini, Olivia Burling, Lauren Thurgood, Edwin J Iwanowicz

Leuk Lymphoma· May 2024

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Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.
Emily M J Fennell, Lucas J Aponte-Collazo, Wimal Pathmasiri, Blake R Rushing, Natalie K Barker, Edwin J Iwanowicz

Front Pharmacol· March 2023

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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mark F Mabanglo, Keith S Wong, Marim M Barghash, Elisa Leung, Stephanie H W Chuang, Andrew A Iwanowicz, Edwin J Iwanowicz

Structure· February 2023

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Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis.
Yoshimi Endo Greer, Lidia Hernandez, Emily M J Fennell, Manjari Kundu, Donna Voeller, Edwin Iwanowicz

Cancer Res Commun· October 2022

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Correction to "Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues".
Paul R Graves, Lucas J Aponte-Collazo, Emily M J Fennell, Adam C Graves, Andrew E Hale, Edwin J Iwanowicz

ACS Chem Biol· August 2022

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Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
Emily M J Fennell, Lucas J Aponte-Collazo, Joshua D Wynn, Kristina Drizyte-Miller, Elisa Leung, Andrew A Iwanowicz, Edwin J Iwanowicz

Pharmacol Res Perspect· August 2022

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The ClpP activator ONC-212 (TR-31) inhibits BCL2 and B-cell receptor signaling in CLL.
Narjis Fatima, Yandong Shen, Kyle Crassini, Edwin J Iwanowicz, Henk Lang

EJHaem· February 2021

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Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues.
Paul R Graves, Lucas J Aponte-Collazo, Emily M J Fennell, Adam C Graves, Andrew E Hale, Edwin J Iwanowicz

ACS Chem Biol· May 2019

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Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Scott H Watterson, Ping Chen, Yufen Zhao, Henry H Gu, T G Murali Dhar, Edwin J Iwanowicz

J Med Chem· July 2007

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Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
Dominique Potin, Michele Launay, Francoise Monatlik, Patrice Malabre, Maud Fabreguettes, Edwin J Iwanowicz

J Med Chem· November 2006

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De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Dominique Potin, Michele Launay, Eric Nicolai, Maud Fabreguette, Patrice Malabre, Edwin J Iwanowicz

Bioorg Med Chem Lett· February 2005

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Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
Ping Chen, Arthur M Doweyko, Derek Norris, Henry H Gu, Steven H Spergel, Edwin J Iwanowicz

J Med Chem· August 2004

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3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
T G Murali Dhar, Zhongqi Shen, Henry H Gu, Ping Chen, Derek Norris, Edwin J Iwanowicz

Bioorg Med Chem Lett· October 2003

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Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Edwin J Iwanowicz, Scott H Watterson, Junqing Guo, William J Pitts, T G Murali Dhar

Bioorg Med Chem Lett· June 2003

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Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Scott H Watterson, T G Murali Dhar, Shelley K Ballentine, Zhongqi Shen, Joel C Barrish, Edwin J Iwanowicz

Bioorg Med Chem Lett· April 2003

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Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Ping Chen, Derek Norris, Kristin D Haslow, T G Murali Dhar, William J Pitts, Edwin J Iwanowicz

Bioorg Med Chem Lett· April 2003

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Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Scott H Watterson, Marianne Carlsen, T G Murali Dhar, Zhongqi Shen, William J Pitts, Edwin J Iwanowicz

Bioorg Med Chem Lett· February 2003

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Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
T G Murali Dhar, Scott H Watterson, Ping Chen, Zhongqi Shen, Henry H Gu, Edwin J Iwanowicz

Bioorg Med Chem Lett· February 2003

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A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
T G Murali Dhar, Chunjian Liu, William J Pitts, Junquing Guo, Scott H Watterson, Edwin J Iwanowicz

Bioorg Med Chem Lett· November 2002

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Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.
Ping Chen, Edwin J Iwanowicz, Derek Norris, Henry H Gu, James Lin

Bioorg Med Chem Lett· November 2002

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Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity.
Edwin J Iwanowicz, S David Kimball, James Lin, Wan Lau, W-C Han

Bioorg Med Chem Lett· November 2002

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The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.
T G Murali Dhar, Zhongqi Shen, Catherine A Fleener, Katherine A Rouleau, Joel C Barrish, Edwin J Iwanowicz

Bioorg Med Chem Lett· November 2002

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Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Edwin J Iwanowicz, Scott H Watterson, Chunjian Liu, Henry H Gu, Toomas Mitt

Bioorg Med Chem Lett· October 2002

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