Publications by authors named "Ehsan Irajizad"

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SMAGS-LASSO: A Novel Feature Selection Method for Sensitivity Maximization in Early Cancer Detection.
Hamid Khoshfekr Rudsari, Sara Khorami-Sarvestani, Johannes F Fahrmann, James P Long, Samir Hanash, Ehsan Irajizad

Cancer Epidemiol Biomarkers Prev· December 2025

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Digital twins in healthcare: a comprehensive review and future directions.
Hamid Khoshfekr Rudsari, Becky Tseng, Hongxu Zhu, Lulu Song, Chunhui Gu, Ehsan Irajizad

Front Digit Health· December 2025

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Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy.
Yihui Chen, Rongzhang Dou, Monica J Hong, Hanwen Xu, Jody Vykoukal, Ehsan Irajizad

Cell Rep Med· December 2025

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Vesicle-mediated mitochondrial clearance presents an actionable metabolic vulnerability in triple-negative breast cancer.
Jody Vykoukal, Yihui Chen, Mingxin Zuo, Riccardo Ballarò, Monica J Hong, Ehsan Irajizad

Cell Rep Med· December 2025

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Validation of a blood test for multi-cancer risk stratification in a lung cancer screening cohort.
Johannes F Fahrmann, Ehsan Irajizad, Hamid Rudsari, Jody Vykoukal, Iakovos Toumazis

medRxiv· November 2025

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Breast cancer risk assessment: current challenges and the emerging role of blood-based protein biomarkers.
Ehsan Irajizad, Sam Hanash

J Natl Cancer Inst· October 2025

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Long-chain sulfatide enrichment is an actionable metabolic vulnerability in intraductal papillary mucinous neoplasm (IPMN)-associated pancreatic cancers.
Yihui Chen, Riccardo Ballarò, Marta Sans, Fredrik Ivar Thege, Mingxin Zuo, Ehsan Irajizad

Gut· September 2025

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Cyst fluid proteins stratify malignant risk of intraductal papillary mucinous neoplasm of the pancreas.
Chunliang Liu, Amber Mosley, Ehsan Irajizad, Michele Yip-Schneider, Huangbing Wu

Cancer Lett· August 2025

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Minimizing and quantifying uncertainty in AI-informed decisions: Applications in medicine.
Samuel D Curtis, Sambit Panda, Adam Li, Haoyin Xu, Yuxin Bai, Ehsan Irajizad

Proc Natl Acad Sci U S A· August 2025

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AUPRC: a metric for evaluating the performance of in-silico perturbation methods in identifying differentially expressed genes.
Hongxu Zhu, Amir Asiaee, Leila Azinfar, Jun Li, Han Liang, Ehsan Irajizad

Brief Bioinform· August 2025

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Mutation dynamics from diagnosis to relapse in acute myeloid leukemia with chromosomal 7 deletions.
Eitan Kugler, Enes Dasdemir, Alex Bataller, Bofei Wang, Courtney D DiNardo, Ehsan Irajizad

Leuk Lymphoma· July 2025

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Integrated Metabolomics and Spatial Transcriptomics of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism as a Biomarker of Progression.
Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider

Clin Cancer Res· June 2025

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Impact of Comorbidities on the Mortality Benefits of Lung Cancer Screening: A Post-Hoc Analysis of the PLCO and NLST Trials.
Sebastien Gendarme, Ehsan Irajizad, James P Long, Johannes F Fahrmann, Jennifer B Dennison

J Thorac Oncol· May 2025

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Elevated levels of circulating microbial-associated uremic toxins are associated with metastatic duodenopancreatic neuroendocrine tumors in patients with Multiple Endocrine Neoplasia Type 1.
Riccardo Ballarò, Amanda R Wasylishen, Carolina R C Pieterman, Courtney Olsen, Ehsan Irajizad

Cancer Lett· April 2025

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Grape-Pi: graph-based neural networks for enhanced protein identification in proteomics pipelines.
Chunhui Gu, Seyyed Mahmood Ghasemi, Yining Cai, Johannes F Fahrmann, James P Long, Ehsan Irajizad

Bioinform Adv· April 2025

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A Novel Sensitivity Maximization at a Given Specificity Method for Binary Classifications.
Seyyed Mahmood Ghasemi, Chunhui Gu, Johannes F Fahrmann, Samir Hanash, Kim-Anh Do, Ehsan Irajizad

Cancer Prev Res (Phila)· March 2025

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Lead time trajectory of blood-based protein biomarkers for detection of pancreatic cancer based on repeat testing.
Johannes F Fahrmann, Michele Yip-Schneider, Jody Vykoukal, Rachelle Spencer, Jennifer B Dennison, Ehsan Irajizad

Cancer Lett· March 2025

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AUC-PR is a More Informative Metric for Assessing the Biological Relevance of In Silico Cellular Perturbation Prediction Models.
Hongxu Zhu, Amir Asiaee, Leila Azinfar, Jun Li, Han Liang, Ehsan Irajizad

bioRxiv· March 2025

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Estimating sojourn time and sensitivity of screening for ovarian cancer using a Bayesian framework.
Sayaka Ishizawa, Jiangong Niu, Martin C Tammemagi, Ehsan Irajizad, Yu Shen

J Natl Cancer Inst· November 2024

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Validation of a prognostic blood-based sphingolipid panel for men with localized prostate cancer followed on active surveillance.
Justin R Gregg, Lisa Newcomb, Ranran Wu, Jennifer Dennison, John W Davis, Ehsan Irajizad

Biomark Res· November 2024

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Biomarker trajectory for earlier detection of lung cancer.
Ehsan Irajizad, Johannes F Fahrmann, Iakovos Toumazis, Jody Vykoukal, Jennifer B Dennison

EBioMedicine· October 2024

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A metabolite-based liquid biopsy for detection of ovarian cancer.
Johannes F Fahrmann, Seyyed Mahmood Ghasemi, Chae Y Han, Ranran Wu, Jennifer B Dennison, Ehsan Irajizad

Biomark Res· August 2024

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Validation of a Blood-Based Protein Biomarker Panel for a Risk Assessment of Lethal Lung Cancer in the Physicians' Health Study.
Lulu Song, Ehsan Irajizad, Andrew Rundle, Howard D Sesso, John Michael Gaziano

Cancers (Basel)· May 2024

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A novel method to guide biomarker combinations to optimize the sensitivity.
Seyyed Mahmood Ghasem, Johannes F Fahrmann, Samir Hanash, Kim-Anh Do, James P Long, Ehsan Irajizad

bioRxiv· April 2024

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A Blood-based Metabolite Signature for Personalized Risk Assessment of Pancreatic Cancer.
Ricardo A León-Letelier, Yihui Chen, Riccardo Ballaro, Ehsan Irajizad, Kim-An Do

J Cancer Immunol (Wilmington)· January 2024

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