Publications by authors named "Elie Needle"

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Horizontal Transmission of Cytomegalovirus in a Rhesus Model Despite High-Level, Vaccine-Elicited Neutralizing Antibody and T-Cell Responses.
Julia Li, Sabine Wellnitz, Xiaoyuan S Chi, Yujuan Yue, Kimberli A Schmidt, Elie Needle

J Infect Dis· September 2022

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Long-term effectiveness of live herpes zoster vaccine in patients with rheumatoid arthritis subsequently treated with tofacitinib.
Kevin L Winthrop, Ann Wouters, Ernest H Choy, Connie Chen, Pinaki Biswas, Elie Needle

Ann Rheum Dis· May 2020

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LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits.
Marco A S Baptista, Kalpana Merchant, Ted Barrett, Sakshi Bhargava, Dianne K Bryce, Elie Needle

Sci Transl Med· April 2020

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The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
Kevin L Winthrop, Ann G Wouters, Ernest H Choy, Koshika Soma, Jennifer A Hodge, Elie Needle

Arthritis Rheumatol· October 2017

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Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Anastasia G Henry, Soheil Aghamohammadzadeh, Harry Samaroo, Yi Chen, Kewa Mou, Elie Needle

Hum Mol Genet· November 2015

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Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.
João P L Daher, Hisham A Abdelmotilib, Xianzhen Hu, Laura A Volpicelli-Daley, Mark S Moehle, Elie Needle

J Biol Chem· August 2015

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Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor.
Jaclyn L Henderson, Bethany L Kormos, Matthew M Hayward, Karen J Coffman, Jayasankar Jasti, Elie Needle

J Med Chem· January 2015

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Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold.
Paul Galatsis, Jaclyn L Henderson, Bethany L Kormos, Seungil Han, Ravi G Kurumbail, Elie Needle

Bioorg Med Chem Lett· September 2014

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Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1.
Gregory C Luerman, Chuong Nguyen, Harry Samaroo, Paula Loos, Hualin Xi, Elie Needle

J Neurochem· February 2014

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Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice.
Liam Scott, Jianlin Feng, Tamás Kiss, Elie Needle, Kevin Atchison

Neurobiol Aging· July 2012

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Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2.
Peter J Atkinson, Tammy Dellovade, David Albers, David Von Schack, Kathryn Saraf, Elie Needle

J Neurochem· March 2009

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Protein kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but phosphatidylinositol-3-kinase and mitogen-activated protein kinase independent.
Elie Needle, Kathy Piparo, Donna Cole, Carolyn Worrall, Ian Whitehead

Biol Reprod· July 2007

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