Publications by authors named "Elizabeth Sprague"

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A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes.
Benika J Pinch, Dennis L Buckley, Scott Gleim, Scott M Brittain, Laura Tandeske, Elizabeth R Sprague

Cell Chem Biol· January 2022

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The impact of structural biology in medicine illustrated with four case studies.
Tiancen Hu, Elizabeth R Sprague, Michelle Fodor, Travis Stams, Kirk L Clark

J Mol Med (Berl)· January 2018

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Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
Grazia Piizzi, David T Parker, Yunshan Peng, Markus Dobler, Anup Patnaik, Elizabeth R Sprague

J Med Chem· June 2017

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"Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.
Xin Chen, John Giraldes, Elizabeth R Sprague, Subarna Shakya, Zhuoliang Chen

J Med Chem· March 2017

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Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
B Barry Touré, John Giraldes, Troy Smith, Elizabeth R Sprague, Yaping Wang

J Med Chem· May 2016

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Konstantinos J Mavrakis, E Robert McDonald, Michael R Schlabach, Eric Billy, Gregory R Hoffman, Elizabeth R Sprague

Science· March 2016

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Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension.
Duncan Shaw, Greg Hollingworth, Nicolas Soldermann, Elizabeth Sprague, Walter Schuler

Bioorg Med Chem Lett· October 2014

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An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Andrew P Garner, Carl U Bialucha, Elizabeth R Sprague, Joan T Garrett, Qing Sheng

Cancer Res· October 2013

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Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the gram-negative pathogen Pseudomonas aeruginosa.
Ruth E Caughlan, Adriana K Jones, Angela M Delucia, Angela L Woods, Lili Xie, Elizabeth R Sprague

Antimicrob Agents Chemother· January 2012

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The human cytomegalovirus Fc receptor gp68 binds the Fc CH2-CH3 interface of immunoglobulin G.
Elizabeth R Sprague, Henrike Reinhard, Evelyn J Cheung, Alexander H Farley, Robin Deis Trujillo

J Virol· April 2008

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Crystal structure of the HSV-1 Fc receptor bound to Fc reveals a mechanism for antibody bipolar bridging.
Elizabeth R Sprague, Chu Wang, David Baker, Pamela J Bjorkman

PLoS Biol· June 2006

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pH dependence and stoichiometry of binding to the Fc region of IgG by the herpes simplex virus Fc receptor gE-gI.
Elizabeth R Sprague, W Lance Martin, Pamela J Bjorkman

J Biol Chem· April 2004

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