Publications by authors named "Emma Scaletti"

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Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.
Emily C Hank, Nicholas D D'Arcy-Evans, Emma Rose Scaletti, Carlos Benítez-Buelga, Olov Wallner

RSC Chem Biol· October 2025

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Virtual fragment screening for DNA repair inhibitors in vast chemical space.
Andreas Luttens, Duc Duy Vo, Emma R Scaletti, Elisée Wiita, Ingrid Almlöf

Nat Commun· February 2025

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Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.
Emma R Scaletti, Judith E Unterlass, Ingrid Almlöf, Tobias Koolmeister, Karl S Vallin

FEBS J· October 2024

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Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
Emma R Scaletti, Pontus Pettersson, Joan Patrick, Patrick J Shilling, Robert Gustafsson Westergren

J Biol Chem· October 2023

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Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
Olov Wallner, Armando Cázares-Körner, Emma Rose Scaletti, Geoffrey Masuyer, Tove Bekkhus

ChemMedChem· January 2023

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The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.
Emma R Scaletti, Robert Gustafsson Westergren, Yasmin Andersson, Elisee Wiita, Martin Henriksson

ChemMedChem· September 2022

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Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.
Ann-Sofie Jemth, Emma Rose Scaletti, Evert Homan, Pål Stenmark, Thomas Helleday

J Biol Chem· August 2022

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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Maurice Michel, Carlos Benítez-Buelga, Patricia A Calvo, Bishoy M F Hanna, Oliver Mortusewicz, Emma R Scaletti

Science· June 2022

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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nadilly Bonagas, Nina M S Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Emma R Scaletti

Nat Cancer· February 2022

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Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile .
Daniel Rehling, Emma Rose Scaletti, Inna Rozman Grinberg, Daniel Lundin, Margareta Sahlin

Biochemistry· January 2022

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Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives.
Emma Scaletti, Franziska U Huschmann, Uwe Mueller, Manfred S Weiss, Norbert Sträter

Purinergic Signal· December 2021

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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Emma Scaletti

J Biol Chem· August 2021

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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors.
Ehesan U Sharif, Jaroslaw Kalisiak, Kenneth V Lawson, Dillon H Miles, Eric Newcomb, Emma R Scaletti

J Med Chem· January 2021

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Discovery of AB680: A Potent and Selective Inhibitor of CD73.
Kenneth V Lawson, Jaroslaw Kalisiak, Erick A Lindsey, Eric T Newcomb, Manmohan Reddy Leleti, Emma Scaletti

J Med Chem· October 2020

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MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
Emma Rose Scaletti, Karl S Vallin, Lars Bräutigam, Antonio Sarno, Ulrika Warpman Berglund

J Biol Chem· April 2020

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2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
Sanjay Bhattarai, Jan Pippel, Emma Scaletti, Riham Idris, Marianne Freundlieb

J Med Chem· March 2020

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Massively parallel variant characterization identifies alleles associated with thiopurine toxicity.
Chase C Suiter, Takaya Moriyama, Kenneth A Matreyek, Wentao Yang, Emma Rose Scaletti

Proc Natl Acad Sci U S A· March 2020

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The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Emma Scaletti, Magnus Claesson, Thomas Helleday, Ann-Sofie Jemth, Pål Stenmark

J Mol Biol· February 2020

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Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Emma Scaletti, Ann-Sofie Jemth, Thomas Helleday, Pål Stenmark

FEBS Lett· July 2019

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Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Ann-Sofie Jemth, Emma Scaletti, Megan Carter, Thomas Helleday, Pål Stenmark

Biochemistry· February 2019

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Structural features and kinetic characterization of alanine racemase from Staphylococcus aureus (Mu50).
Emma R Scaletti, Sylvia R Luckner, Kurt L Krause

Acta Crystallogr D Biol Crystallogr· January 2012

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