Publications by authors named "Evert Homan"

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Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1.
Marek Varga, Florian Ortis, Alicia Del Prado, Alice Eddershaw, Emma Scaletti Hutchinson, Evert J Homan

J Med Chem· November 2025

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Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.
Emily C Hank, Nicholas D D'Arcy-Evans, Emma Rose Scaletti, Carlos Benítez-Buelga, Olov Wallner, Evert J Homan

RSC Chem Biol· October 2025

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Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP-Lyase Function.
Mario Kehler, Kaixin Zhou, Aurino M Kemas, Alicia Del Prado, Emma Scaletti Hutchinson, Evert J Homan

Chemistry· June 2025

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Virtual fragment screening for DNA repair inhibitors in vast chemical space.
Andreas Luttens, Duc Duy Vo, Emma R Scaletti, Elisée Wiita, Ingrid Almlöf, Evert Homan

Nat Commun· February 2025

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GPCR Function in Autophagy Control: A Systematic Approach of Chemical Intervention.
Pablo Sanz-Martinez, Georg Tascher, Sara Cano-Franco, Paloma Cabrerizo-Poveda, Christian Münch, Evert J Homan

J Mol Biol· August 2024

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Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily.
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A M Mocking, Ulrich Goldmann, Evert J Homan

Front Pharmacol· July 2024

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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
Si Min Zhang, Cynthia B J Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Evert J Homan

iScience· February 2024

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PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands.
Icaro A Simon, Evert J Homan, Maikel Wijtmans, Michael Sundström, Rob Leurs

J Chem Inf Model· November 2023

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Target 2035 - an update on private sector contributions.
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Evert Homan

RSC Med Chem· June 2023

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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Alanna C Green, Petra Marttila, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Evert Homan

Nat Metab· April 2023

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Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
Olov Wallner, Armando Cázares-Körner, Emma Rose Scaletti, Geoffrey Masuyer, Tove Bekkhus, Evert Homan

ChemMedChem· January 2023

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The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.
Emma R Scaletti, Robert Gustafsson Westergren, Yasmin Andersson, Elisee Wiita, Martin Henriksson, Evert J Homan

ChemMedChem· September 2022

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Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.
Ann-Sofie Jemth, Emma Rose Scaletti, Evert Homan, Pål Stenmark, Thomas Helleday

J Biol Chem· August 2022

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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Maurice Michel, Carlos Benítez-Buelga, Patricia A Calvo, Bishoy M F Hanna, Oliver Mortusewicz, Evert J Homan

Science· June 2022

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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nadilly Bonagas, Nina M S Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Evert J Homan

Nat Cancer· February 2022

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Target 2035 - update on the quest for a probe for every protein.
Susanne Müller, Suzanne Ackloo, Arij Al Chawaf, Bissan Al-Lazikani, Albert Antolin, Evert Homan

RSC Med Chem· January 2022

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
Si Min Zhang, Daniel Rehling, Ann-Sofie Jemth, Adam Throup, Natalia Landázuri, Evert J Homan

Cell Chem Biol· December 2021

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Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
Daniel Rehling, Si Min Zhang, Ann-Sofie Jemth, Tobias Koolmeister, Adam Throup, Evert Homan

J Biol Chem· August 2021

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Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Torkild Visnes, Carlos Benítez-Buelga, Armando Cázares-Körner, Kumar Sanjiv, Bishoy M F Hanna, Evert J Homan

Nucleic Acids Res· December 2020

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Development of a chemical probe against NUDT15.
Si Min Zhang, Matthieu Desroses, Anna Hagenkort, Nicholas C K Valerie, Daniel Rehling, Evert J Homan

Nat Chem Biol· October 2020

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Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Jana Škerlová, Judith Unterlass, Mona Göttmann, Petra Marttila, Evert Homan

J Biol Chem· August 2020

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Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization.
Maurice Michel, Evert J Homan, Elisée Wiita, Kia Pedersen, Ingrid Almlöf

Front Chem· May 2020

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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Brent D G Page, Nicholas C K Valerie, Roni H G Wright, Olov Wallner, Rebecka Isaksson, Evert Homan

Nat Commun· November 2019

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Computational and Experimental Druggability Assessment of Human DNA Glycosylases.
Maurice Michel, Torkild Visnes, Evert J Homan, Brinton Seashore-Ludlow, Mattias Hedenström

ACS Omega· July 2019

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Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Torkild Visnes, Armando Cázares-Körner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Evert J Homan

Science· November 2018

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