Publications by authors named "Eric A Toth"

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Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO Cells.
Mina Ying Min Wu, Frances Rocamora, Caressa M Robinson, Seunghyeon Shin, Svetlana Maurya, Eric A Toth

Biotechnol J· September 2025

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Polyphosphazene-Mediated Assembly of TLR4 and TLR7/8 Agonists Enables a Potent Nano-Adjuvant Delivery System for Hepatitis C Virus Vaccine Antigens.
Alexander K Andrianov, Alexander Marin, Sarah Jeong, Liudmila Kulakova, Ananda Chowdhury, Eric A Toth

Vaccines (Basel)· September 2025

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Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity.
Liudmila Kulakova, Kiki H Li, Austin W T Chiang, Michael P Schwoerer, Saori Suzuki, Eric A Toth

NPJ Vaccines· June 2025

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Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Salman Shahid, Sharanbasappa S Karade, S Saif Hasan, Rui Yin, Liqun Jiang, Eric A Toth

Commun Biol· May 2025

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Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design.
Linling He, Yi-Zong Lee, Yi-Nan Zhang, Maddy L Newby, Benjamin M Janus, Eric A Toth

bioRxiv· May 2025

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Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells.
Mina Ying Min Wu, Frances Rocamora, Caressa M Robinson, Seunghyeon Shin, Eric A Toth

bioRxiv· May 2025

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Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity.
Liudmila Kulakova, Kiki H Li, Austin W T Chiang, Michael P Schwoerer, Sanne Schoffelen, Eric A Toth

bioRxiv· April 2025

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Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist-Synthesis, Characterization, and In Vivo Activity.
Thomas R Fuerst, Alexander Marin, Sarah Jeong, Liudmila Kulakova, Raman Hlushko, Eric A Toth

J Funct Biomater· January 2025

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Site-directed neutralizing antibodies targeting structural sites on SARS-CoV-2 spike protein.
Xiaofeng Li, Liudmila Kulakova, Kezzia Jones, Eric A Toth, Marina Kirkland Mitchell

N Biotechnol· May 2024

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Hepatitis C Virus E1E2 Structure, Diversity, and Implications for Vaccine Development.
Brian G Pierce, Nathaniel Felbinger, Matthew Metcalf, Eric A Toth, Gilad Ofek

Viruses· May 2024

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Glycoengineered recombinant alpha1-antitrypsin results in comparable and activities to human plasma-derived protein.
Frances Rocamora, Sanne Schoffelen, Johnny Arnsdorf, Eric A Toth, Yunus Abdul

bioRxiv· March 2024

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Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies.
Frances Rocamora, Angelo G Peralta, Seunghyeon Shin, James Sorrentino, Mina Ying Min Wu, Eric A Toth

Biotechnol Adv· October 2023

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Prospects for developing an Hepatitis C virus E1E2-based nanoparticle vaccine.
Eric A Toth, Alexander K Andrianov, Thomas R Fuerst

Rev Med Virol· September 2023

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Structure of engineered hepatitis C virus E1E2 ectodomain in complex with neutralizing antibodies.
Matthew C Metcalf, Benjamin M Janus, Rui Yin, Ruixue Wang, Johnathan D Guest, Eric A Toth

Nat Commun· July 2023

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Skin Vaccination with Ebola Virus Glycoprotein Using a Polyphosphazene-Based Microneedle Patch Protects Mice against Lethal Challenge.
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M Janus, Eric I Felner, Eric A Toth

J Funct Biomater· December 2022

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Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate.
Ruixue Wang, Saori Suzuki, Johnathan D Guest, Brigitte Heller, Maricar Almeda, Eric A Toth

Proc Natl Acad Sci U S A· March 2022

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Structural and Biophysical Characterization of the HCV E1E2 Heterodimer for Vaccine Development.
Eric A Toth, Andrezza Chagas, Brian G Pierce, Thomas R Fuerst

Viruses· May 2021

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Engineering subtilisin proteases that specifically degrade active RAS.
Yingwei Chen, Eric A Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman

Commun Biol· March 2021

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Design of a native-like secreted form of the hepatitis C virus E1E2 heterodimer.
Johnathan D Guest, Ruixue Wang, Khadija H Elkholy, Andrezza Chagas, Kinlin L Chao, Eric A Toth

Proc Natl Acad Sci U S A· January 2021

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Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.
Brian G Pierce, Zhen-Yong Keck, Ruixue Wang, Patrick Lau, Kyle Garagusi, Eric A Toth

J Virol· October 2020

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Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site.
Lakshmi Swarna Mukhi Pidugu, Heather Neu, Tin Lok Wong, Edwin Pozharski, John L Molloy, Eric A Toth

Acta Crystallogr D Struct Biol· April 2017

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Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein.
Maryanna E Lanning, Wenbo Yu, Jeremy L Yap, Jay Chauhan, Lijia Chen, Eric A Toth

Eur J Med Chem· May 2016

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Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations.
Michael C Cavalier, Mohd Imran Ansari, Adam D Pierce, Paul T Wilder, Laura E McKnight, Eric A Toth

J Med Chem· January 2016

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Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2.
Rena G Lapidus, Brandon A Carter-Cooper, Mariola Sadowska, Eun Yong Choi, Omasiri Wonodi, Eric A Toth

Pharmaceuticals (Basel)· January 2016

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A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
Lakshmi Swarna Mukhi Pidugu, J C Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A Sausville, Eric A Toth

BMC Struct Biol· January 2016

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