Publications by authors named "Eric Feyfant"

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Discovery of Sulanemadlin (ALRN-6924), the First Cell-Permeating, Stabilized α-Helical Peptide in Clinical Development.
Vincent Guerlavais, Tomi K Sawyer, Luis Carvajal, Yong S Chang, Bradford Graves, Eric Feyfant

J Med Chem· July 2023

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The Role of Bridging Water and Hydrogen Bonding as Key Determinants of Noncovalent Protein-Carbohydrate Recognition.
Anatoly M Ruvinsky, Ishita Aloni, Daniel Cappel, Chris Higgs, Kyle Marshall, Eric Feyfant

ChemMedChem· December 2018

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Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
David J Hughes, Christian Tiede, Natalie Penswick, Anna Ah-San Tang, Chi H Trinh, Eric Feyfant

Sci Signal· November 2017

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Predicting the Effect of Amino Acid Single-Point Mutations on Protein Stability-Large-Scale Validation of MD-Based Relative Free Energy Calculations.
Thomas Steinbrecher, Chongkai Zhu, Lingle Wang, Robert Abel, Christopher Negron, Eric Feyfant

J Mol Biol· April 2017

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Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing.
Meera E Modi, Mark J Majchrzak, Kari R Fonseca, Angela Doran, Sarah Osgood, Eric Feyfant

J Pharmacol Exp Ther· August 2016

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A general approach to site-specific antibody drug conjugates.
Feng Tian, Yingchun Lu, Anthony Manibusan, Aaron Sellers, Hon Tran, Eric Feyfant

Proc Natl Acad Sci U S A· February 2014

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Development of an informatics platform for therapeutic protein and peptide analytics.
Mark R Hansen, Hugo O Villar, Eric Feyfant

J Chem Inf Model· October 2013

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Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
Yong S Chang, Bradford Graves, Vincent Guerlavais, Christian Tovar, Kathryn Packman, Eric Feyfant

Proc Natl Acad Sci U S A· September 2013

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Fragment-based drug design.
Eric Feyfant, Jason B Cross, Kevin Paris, Désirée H H Tsao

Methods Mol Biol· February 2011

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A protein relational database and protein family knowledge bases to facilitate structure-based design analyses.
Dominick Mobilio, Gary Walker, Natasja Brooijmans, Ramaswamy Nilakantan, R Aldrin Denny, Eric Feyfant

Chem Biol Drug Des· August 2010

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A structural informatics approach to mine kinase knowledge bases.
Natasja Brooijmans, Dominick Mobilio, Gary Walker, Ramaswamy Nilakantan, Rajiah A Denny, Eric Feyfant

Drug Discov Today· March 2010

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Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Darrin W Hopper, Matthew D Vera, David How, Joshua Sabatini, Jason S Xiang, Eric Feyfant

Bioorg Med Chem Lett· May 2009

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CONFIRM: connecting fragments found in receptor molecules.
David C Thompson, R Aldrin Denny, Ramaswamy Nilakantan, Christine Humblet, Diane Joseph-McCarthy, Eric Feyfant

J Comput Aided Mol Des· October 2008

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Modeling mutations in protein structures.
Eric Feyfant, Andrej Sali, András Fiser

Protein Sci· September 2007

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Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors.
Henry-Georges Lombart, Eric Feyfant, Diane Joseph-McCarthy, Adrian Huang, Frank Lovering

Bioorg Med Chem Lett· August 2007

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Lead optimization via high-throughput molecular docking.
Diane Joseph-McCarthy, J Christian Baber, Eric Feyfant, David C Thompson, Christine Humblet

Curr Opin Drug Discov Devel· May 2007

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Functional, biophysical, and structural bases for antibacterial activity of tigecycline.
Matthew W Olson, Alexey Ruzin, Eric Feyfant, Thomas S Rush, John O'Connell

Antimicrob Agents Chemother· June 2006

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