Publications by authors named "Fabio Bertozzi"

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Molecular targeting of the deubiquitinase USP14 to circumvent cisplatin resistance in ovarian carcinoma and identification of novel inhibitors.
Cristina Corno, Debora Russo, Francesco Pignotti, Francesca De Giorgi, Ilaria Penna, Fabio Bertozzi

Cancer Drug Resist· October 2025

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Oxytocin seals the blood-brain barrier, improving 22q11.2 deletion syndrome trajectories.
Giulia Castellani, Mariasole Ciampoli, Arianna Benedetti, Valentina Ferretti, Gabriella Trigilio, Fabio Bertozzi

Brain· September 2025

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Target Identification with Live-Cell Photoaffinity Labeling and Mechanism of Action Elucidation of ARN23765, a Highly Potent CFTR Corrector.
Elisa Romeo, Francesco Saccoliti, Riccardo Ocello, Angela Andonaia, Caterina Allegretta, Fabio Bertozzi

J Med Chem· February 2025

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Combined in vivo effect of N-acylethanolamine-hydrolyzing acid amidase and glycogen synthase kinase-3β inhibition to treat multiple sclerosis.
Stefania Sgroi, Elisa Romeo, Ennio Albanesi, Federica Piccardi, Federico Catalano, Fabio Bertozzi

Biomed Pharmacother· June 2024

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Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening.
Michele Genovese, Daniela Guidone, Martina Buccirossi, Anna Borrelli, Alejandra Rodriguez-Gimeno, Fabio Bertozzi

PNAS Nexus· January 2023

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Editorial: Protein-Protein Interactions: Drug Discovery for the Future.
Simona Rapposelli, Eugenio Gaudio, Fabio Bertozzi, Sheraz Gul

Front Chem· November 2021

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Inhibition of N-acylethanolamine-hydrolyzing acid amidase reduces T cell infiltration in a mouse model of multiple sclerosis.
Stefania Sgroi, Elisa Romeo, Paolo Di Fruscia, Pier Francesca Porceddu, Debora Russo, Fabio Bertozzi

Pharmacol Res· October 2021

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Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent -Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration.
Paolo Di Fruscia, Anna Carbone, Giovanni Bottegoni, Francesco Berti, Francesca Giacomina, Sine Mandrup Bertozzi, Fabio Bertozzi

J Med Chem· September 2021

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Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment.
Valeria Capurro, Valeria Tomati, Elvira Sondo, Mario Renda, Anna Borrelli, Sine Mandrup Bertozzi, Fabio Bertozzi

Int J Mol Sci· May 2021

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Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1-pyrido[4,3-]indoles as a Novel Class of CFTR Potentiators.
Nicoletta Brindani, Ambra Gianotti, Simone Giovani, Francesca Giacomina, Paolo Di Fruscia, Sine Mandrup Bertozzi, Fabio Bertozzi

J Med Chem· October 2020

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Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.
Pasquale Linciano, Gregorio Cullia, Chiara Borsari, Matteo Santucci, Stefania Ferrari, Sine Mandrup Bertozzi, Fabio Bertozzi

Eur J Med Chem· March 2020

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Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel.
Nicoletta Pedemonte, Fabio Bertozzi, Emanuela Caci, Federico Sorana, Paolo Di Fruscia

Sci Adv· February 2020

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A European regulatory perspective on cystic fibrosis: current treatments, trends in drug development and translational challenges for CFTR modulators.
Stefano Ponzano, Giulia Nigrelli, Laura Fregonese, Irmgard Eichler, Fabio Bertozzi

Eur Respir Rev· June 2018

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Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies.
Andrea Nuzzi, Annalisa Fiasella, Jose Antonio Ortega, Chiara Pagliuca, Stefano Ponzano, Sine Mandrup Bertozzi, Fabio Bertozzi

Eur J Med Chem· March 2016

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Activity-Based Probe for N-Acylethanolamine Acid Amidase.
Elisa Romeo, Stefano Ponzano, Andrea Armirotti, Maria Summa, Fabio Bertozzi

ACS Chem Biol· September 2015

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A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.
Alison Ribeiro, Silvia Pontis, Luisa Mengatto, Andrea Armirotti, Valerio Chiurchiù, Fabio Bertozzi

ACS Chem Biol· August 2015

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Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors.
Stefano Ponzano, Anna Berteotti, Rita Petracca, Romina Vitale, Luisa Mengatto, Fabio Bertozzi

J Med Chem· December 2014

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3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration.
Annalisa Fiasella, Andrea Nuzzi, Maria Summa, Andrea Armirotti, Glauco Tarozzo, Fabio Bertozzi

ChemMedChem· July 2014

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Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors.
Romina Vitale, Giuliana Ottonello, Rita Petracca, Sine Mandrup Bertozzi, Stefano Ponzano, Fabio Bertozzi

ChemMedChem· February 2014

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Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors.
Stefano Ponzano, Fabio Bertozzi, Luisa Mengatto, Mauro Dionisi, Andrea Armirotti

J Med Chem· September 2013

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Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).
Daniela Pizzirani, Chiara Pagliuca, Natalia Realini, Davide Branduardi, Giovanni Bottegoni, Fabio Bertozzi

J Med Chem· May 2013

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β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine.
Andrea Armirotti, Elisa Romeo, Stefano Ponzano, Luisa Mengatto, Mauro Dionisi, Fabio Bertozzi

ACS Med Chem Lett· May 2012

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Neuropeptide FF receptors have opposing modulatory effects on nociception.
Jelveh Lameh, Fabio Bertozzi, Nicholas Kelly, Paula M Jacobi, Derek Nguyen

J Pharmacol Exp Ther· July 2010

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Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists.
Gilles Gaubert, Fabio Bertozzi, Nicholas M Kelly, Jan Pawlas, Audra L Scully

J Med Chem· November 2009

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Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Nathalie Schlienger, Birgitte W Lund, Jan Pawlas, Fabrizio Badalassi, Fabio Bertozzi

J Med Chem· November 2009

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