Publications by authors named "Fleckner Jan"

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Exploration of Multiple Non-Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients With MASH.
Louise Maymann Nitze, Vlad Ratziu, Arun J Sanyal, Vincent Wai-Sun Wong, Clare Balendran, Jan Fleckner

Aliment Pharmacol Ther· September 2025

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Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis.
Paul Horn, Jenny Norlin, Kasper Almholt, Birgitte M Viuff, Elisabeth D Galsgaard, Jan Fleckner

Elife· October 2024

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Hepatocyte mARC1 promotes fatty liver disease.
Lara C Lewis, Lingyan Chen, L Shahul Hameed, Robert R Kitchen, Cyrielle Maroteau, Shilpa R Nagarajan, Jan Fleckner

JHEP Rep· May 2023

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Exome-Based Rare-Variant Analyses in CKD.
Sophia Cameron-Christie, Charles J Wolock, Emily Groopman, Slavé Petrovski, Sitharthan Kamalakaran, Jan Fleckner

J Am Soc Nephrol· June 2019

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Diagnostic Utility of Exome Sequencing for Kidney Disease.
Emily E Groopman, Maddalena Marasa, Sophia Cameron-Christie, Slavé Petrovski, Vimla S Aggarwal, Debanjana Chatterjee, Jan Fleckner

N Engl J Med· January 2019

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GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.
Claus H Bang-Berthelsen, Thomas L Holm, Charles Pyke, Lotte Simonsen, Rolf Søkilde, Jan Fleckner

Inflamm Bowel Dis· September 2016

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Applying genetics in inflammatory disease drug discovery.
Lasse Folkersen, Shameek Biswas, Klaus Stensgaard Frederiksen, Pernille Keller, Brian Fox, Jan Fleckner

Drug Discov Today· October 2015

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Cytokine detection and simultaneous assessment of rheumatoid factor interference in human serum and synovial fluid using high-sensitivity protein arrays on plasmonic gold chips.
Manfè Valentina, Fleckner Jan, Nørby Lisby Peder, Zhang Bo, Dai Hongjie

BMC Biotechnol· August 2015

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Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.
Katherine E Pinnick, George Nicholson, Konstantinos N Manolopoulos, Siobhán E McQuaid, Philippe Valet, Jan Fleckner

Diabetes· November 2014

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Detection of gene expression signatures related to underlying disease and treatment in rheumatoid arthritis patients.
Kyle A Serikawa, Søren Jacobsen, Dorthe Lundsgaard, Brian A Fox, Lone Hummelshoj, Jan Fleckner

Mod Rheumatol· July 2013

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Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Jane Cheeseman, Jan Fleckner

PLoS Genet· February 2013

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MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.
Mattias Rantalainen, Blanca M Herrera, George Nicholson, Rory Bowden, Quin F Wills, Jan Fleckner

PLoS One· May 2012

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Functional importance of GLP-1 receptor species and expression levels in cell lines.
Lotte Bjerre Knudsen, Sven Hastrup, Christina Rye Underwood, Birgitte Schjellerup Wulff, Jan Fleckner

Regul Pept· April 2012

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Dissociation of antihyperglycaemic and adverse effects of partial perioxisome proliferator-activated receptor (PPAR-gamma) agonist balaglitazone.
Philip J Larsen, Kirsten Lykkegaard, Leif K Larsen, Jan Fleckner, Per Sauerberg

Eur J Pharmacol· October 2008

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Design of potent PPARalpha agonists.
Per Sauerberg, John P Mogensen, Lone Jeppesen, Paul S Bury, Jan Fleckner

Bioorg Med Chem Lett· June 2007

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Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Per Sauerberg, Grith S Olsen, Lone Jeppesen, John P Mogensen, Ingrid Pettersson, Jan Fleckner

J Med Chem· April 2007

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The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice.
Andreas Petri, Jonas Ahnfelt-Rønne, Klaus Stensgaard Frederiksen, David George Edwards, Dennis Madsen, Jan Fleckner

J Mol Endocrinol· October 2006

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Proteome profiling in the rat Harderian gland.
Jae-Won Yang, Leila Afjehi-Sadat, Ellen Gelpi, Markus Kunze, Harald Höger, Jan Fleckner

J Proteome Res· July 2006

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Selective PPAR agonists for the treatment of type 2 diabetes.
Jan O Nehlin, John P Mogensen, Ingrid Petterson, Lone Jeppesen, Jan Fleckner

Ann N Y Acad Sci· May 2006

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Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats.
Sophia G Moesgaard, Christian L Brand, Jeppe Sturis, Bo Ahrén, Michael Wilken, Jan Fleckner

Am J Physiol Endocrinol Metab· June 2005

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Structure-activity relationships of dimeric PPAR agonists.
Per Sauerberg, John P Mogensen, Lone Jeppesen, L Anders Svensson, Jan Fleckner, Jan Nehlin

Bioorg Med Chem Lett· March 2005

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Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas.
Mads Wichmann Matthiessen, Gitte Pedersen, Tatjana Albrektsen, Sven Adamsen, Jan Fleckner

Scand J Gastroenterol· February 2005

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Artifactual insulin release from differentiated embryonic stem cells.
Mattias Hansson, Anna Tonning, Ulrik Frandsen, Andreas Petri, Jayaraj Rajagopal, Jan Fleckner

Diabetes· October 2004

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Array-A-Lizer: a serial DNA microarray quality analyzer.
Andreas Petri, Jan Fleckner, Mads Wichmann Matthiessen

BMC Bioinformatics· February 2004

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Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process.
Lise Madsen, Rasmus K Petersen, Morten B Sørensen, Claus Jørgensen, Philip Hallenborg, Jan Fleckner

Biochem J· November 2003

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