Publications by authors named "Frances Wiseman"

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Clinical Manifestations.
Natalie S Ryan, Clíona Farrell, Nanet Willumsen, Helen Rice, Moneeb Nasir, Frances K Wiseman

Alzheimers Dement· December 2025

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Clinical Manifestations.
Natalie S Ryan, Clíona Farrell, Moneeb Nasir, Nanet Willumsen, Ricardo G Pires, Frances K Wiseman

Alzheimers Dement· December 2025

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Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.
Sevda Boyanova, Gareth Banks, Tatiana V Lipina, Rasneer Sonia Bains, Hamish Forrest, Frances K Wiseman

Dis Model Mech· August 2025

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Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.
Yixing Wu, Karen Cleverley, Frances K Wiseman

PLoS One· May 2025

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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Frances K Wiseman

Acta Neuropathol· May 2025

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Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome-Alzheimer's disease.
Clíona Farrell, Yazead Buhidma, Paige Mumford, Wendy E Heywood, Jenny Hällqvist, Frances K Wiseman

bioRxiv· February 2025

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A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia.
Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C C Jochems, Frances Wiseman

Cereb Circ Cogn Behav· October 2023

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Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Frances K Wiseman

Acta Neuropathol Commun· August 2023

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Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21.
Paige Mumford, Justin Tosh, Silvia Anderle, Eleni Gkanatsiou Wikberg, Gloria Lau, Frances K Wiseman

J Neurosci· August 2022

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Rodent Modeling of Alzheimer's Disease in Down Syndrome: and Approaches.
Clíona Farrell, Paige Mumford, Frances K Wiseman

Front Neurosci· June 2022

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Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome.
Claudia Cannavo, Karen Cleverley, Cheryl Maduro, Paige Mumford, Dale Moulding, Frances K Wiseman

PLoS One· May 2022

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Cell models for Down syndrome-Alzheimer's disease research.
Yixing Wu, Nicole R West, Anita Bhattacharyya, Frances K Wiseman

Neuronal Signal· April 2022

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The effects of Cstb duplication on APP/amyloid-β pathology and cathepsin B activity in a mouse model.
Yixing Wu, Heather T Whittaker, Suzanna Noy, Karen Cleverley, Veronique Brault, Frances K Wiseman

PLoS One· November 2021

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Publisher Correction: Genetic dissection of down syndrome‑associated alterations in APP/amyloid‑β biology using mouse models.
Justin L Tosh, Elena R Rhymes, Paige Mumford, Heather T Whittaker, Laura J Pulford, Frances K Wiseman

Sci Rep· July 2021

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Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society.
Mara Dierssen, Yann Herault, Pablo Helguera, Maria Martínez de Lagran, Anna Vazquez, Frances Wiseman

Mol Syndromol· July 2021

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A novel knockout mouse for the small EDRK-rich factor 2 (Serf2) showing developmental and other deficits.
Karen Cleverley, Weaverly Colleen Lee, Paige Mumford, Toby Collins, Matthew Rickman, Frances K Wiseman

Mamm Genome· April 2021

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Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Justin L Tosh, Elena R Rhymes, Paige Mumford, Heather T Whittaker, Laura J Pulford, Frances K Wiseman

Sci Rep· March 2021

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Using mouse models to understand Alzheimer's disease mechanisms in the context of trisomy of chromosome 21.
Claudia Cannavo, Justin Tosh, Elizabeth M C Fisher, Frances K Wiseman

Prog Brain Res· December 2020

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Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellar cortex of the Tc1 mouse model of down syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI.
Da Ma, Manuel J Cardoso, Maria A Zuluaga, Marc Modat, Nick M Powell, Frances K Wiseman

Neuroimage· December 2020

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Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome.
Pishan Chang, Daniel Bush, Stephanie Schorge, Mark Good, Tara Canonica, Frances K Wiseman

Cell Rep· January 2020

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Gene expression dysregulation domains are not a specific feature of Down syndrome.
Helena Ahlfors, Nneka Anyanwu, Edvinas Pakanavicius, Natalia Dinischiotu, Eva Lana-Elola, Frances Wiseman

Nat Commun· June 2019

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Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Simone Granno, Jonathon Nixon-Abell, Daniel C Berwick, Justin Tosh, George Heaton, Frances K Wiseman

Sci Rep· May 2019

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Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease.
Carla M Startin, Nicholas J Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K Wiseman

Alzheimers Res Ther· March 2019

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The integration site of the transgene in the J20 mouse model of Alzheimer's disease.
Justin L Tosh, Matthew Rickman, Ellie Rhymes, Frances E Norona, Emma Clayton, Frances K Wiseman

Wellcome Open Res· October 2018

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Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.
Frances K Wiseman, Laura J Pulford, Chris Barkus, Fan Liao, Erik Portelius

Brain· August 2018

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