Publications by authors named "George Heaton"

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Targeting specific kinase substrates rescues increased colitis severity induced by the Crohn's disease-linked LRRK2-N2081D variant.
George R Heaton, Xingjian Li, Xianting Li, Xiaoting Zhou, Yuanxi Zhang

J Clin Invest· October 2025

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Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant.
George R Heaton, Xianting Li, Xiaoting Zhou, Yuanxi Zhang, Duc Tung Vu

bioRxiv· September 2024

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Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.
C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, George R Heaton

Immunity· December 2023

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Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration.
C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, George R Heaton

bioRxiv· October 2023

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Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy.
Insup Choi, George R Heaton, You-Kyung Lee, Zhenyu Yue

Sci Adv· October 2022

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Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, George R Heaton

PLoS Biol· May 2022

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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Adamantios Mamais, Jillian H Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G Langston, George R Heaton

PLoS Biol· December 2021

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Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
George R Heaton, Natalie Landeck, Adamantios Mamais, Mike A Nalls, Jonathon Nixon-Abell

Neurobiol Dis· July 2020

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Progress in -Associated Parkinson's Disease Animal Models.
Steven P Seegobin, George R Heaton, Dongxiao Liang, Insup Choi, Marian Blanca Ramirez

Front Neurosci· July 2020

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LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same.
Daniel C Berwick, George R Heaton, Sonia Azeggagh, Kirsten Harvey

Mol Neurodegener· December 2019

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Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Simone Granno, Jonathon Nixon-Abell, Daniel C Berwick, Justin Tosh, George Heaton

Sci Rep· May 2019

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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.
Laura Pellegrini, David N Hauser, Yan Li, Adamantios Mamais, Alexandra Beilina, George Heaton

Hum Mol Genet· September 2018

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Back to the tubule: microtubule dynamics in Parkinson's disease.
Laura Pellegrini, Andrea Wetzel, Simone Grannó, George Heaton, Kirsten Harvey

Cell Mol Life Sci· February 2017

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Ocular biomarkers of Alzheimer's disease.
George R Heaton, Benjamin M Davis, Lisa A Turner, Maria F Cordeiro

Cent Nerv Syst Agents Med Chem· March 2016

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