Publications by authors named "Francesca Perruccio"

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Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
Klemens Hoegenauer, Shaojian An, Jake Axford, Christina Benander, Christian Bergsdorf, Francesca Perruccio

ACS Med Chem Lett· December 2023

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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
Edwige Lorthiois, James Roache, David Barnes-Seeman, Eva Altmann, Ulrich Hassiepen, Francesca Perruccio

J Med Chem· August 2020

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Discovery of Potent and Selective Antibody-Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization.
Alexei S Karpov, Cristina M Nieto-Oberhuber, Tinya Abrams, Edwige Beng-Louka, Enrique Blanco, Francesca Perruccio

ACS Med Chem Lett· December 2019

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Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates.
Alexei S Karpov, Tinya Abrams, Suzanna Clark, Ankita Raikar, Joseph A D'Alessio, Francesca Perruccio

ACS Med Chem Lett· August 2018

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Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
Verena Pries, Christina Nöcker, Danish Khan, Philipp Johnen, Zebin Hong, Francesca Perruccio

Cell Chem Biol· March 2018

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High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.
Ireos Filipuzzi, Simona Cotesta, Francesca Perruccio, Britta Knapp, Yue Fu

PLoS Genet· November 2016

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Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.
Philipp Krastel, Silvio Roggo, Markus Schirle, Nathan T Ross, Francesca Perruccio

Angew Chem Int Ed Engl· August 2015

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Rational design, synthesis and biological evaluation of modular fluorogenic substrates with high affinity and selectivity for PTP1B.
Silvano Sanchini, Francesca Perruccio, Grazia Piizzi

Chembiochem· May 2014

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An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
Paul A Stupple, David V Batchelor, Martin Corless, Patrick K Dorr, David Ellis, Francesca Perruccio

J Med Chem· January 2011

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HPPD: ligand- and target-based virtual screening on a herbicide target.
Miriam López-Ramos, Francesca Perruccio

J Chem Inf Model· May 2010

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High-throughput virtual screening of proteins using GRID molecular interaction fields.
Simone Sciabola, Robert V Stanton, James E Mills, Maria M Flocco, Massimo Baroni, Francesca Perruccio

J Chem Inf Model· January 2010

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High-level QM/MM modelling predicts an arginine as the acid in the condensation reaction catalysed by citrate synthase.
Marc W van der Kamp, Francesca Perruccio, Adrian J Mulholland

Chem Commun (Camb)· April 2008

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Substrate polarization in enzyme catalysis: QM/MM analysis of the effect of oxaloacetate polarization on acetyl-CoA enolization in citrate synthase.
Marc W van der Kamp, Francesca Perruccio, Adrian J Mulholland

Proteins· November 2007

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Ab initio QM/MM modelling of acetyl-CoA deprotonation in the enzyme citrate synthase.
Marc W van der Kamp, Francesca Perruccio, Adrian J Mulholland

J Mol Graph Model· October 2007

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A common reference framework for analyzing/comparing proteins and ligands. Fingerprints for Ligands and Proteins (FLAP): theory and application.
Massimo Baroni, Gabriele Cruciani, Simone Sciabola, Francesca Perruccio, Jonathan S Mason

J Chem Inf Model· May 2007

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