Publications by authors named "Francesca Simorini"

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New antiproliferative agents derived from tricyclic 3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazine scaffold: Synthesis and pharmacological effects.
Marco Robello, Silvia Salerno, Elisabetta Barresi, Paola Orlandi, Francesca Vaglini, Francesca Simorini

Arch Pharm (Weinheim)· November 2022

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Translocator Protein 18-kDa: A Promising Target to Treat Neuroinflammation- related Degenerative Diseases.
Chiara Tremolanti, Lorenzo Germelli, Elisabetta Barresi, Eleonora Da Pozzo, Francesca Simorini

Curr Med Chem· August 2022

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Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-]pyrimidine-Based Antiproliferative Multikinase Inhibitors.
Silvia Salerno, Elisabetta Barresi, Aída Nelly García-Argáez, Sabrina Taliani, Francesca Simorini

ACS Med Chem Lett· April 2019

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Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.
Silvia Salerno, Valeria La Pietra, Mariafrancesca Hyeraci, Sabrina Taliani, Marco Robello, Francesca Simorini

Eur J Med Chem· March 2019

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New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors.
Silvia Salerno, Aída Nelly García-Argáez, Elisabetta Barresi, Sabrina Taliani, Francesca Simorini

Eur J Med Chem· April 2018

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1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.
Vito Coviello, Beatrice Marchi, Stefania Sartini, Luca Quattrini, Anna Maria Marini, Francesca Simorini

J Med Chem· July 2016

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TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.
Anna Santoro, Giuseppina Mattace Raso, Sabrina Taliani, Eleonora Da Pozzo, Francesca Simorini

Eur J Pharm Sci· June 2016

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Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.
Elisabetta Barresi, Silvia Salerno, Anna Maria Marini, Sabrina Taliani, Concettina La Motta, Francesca Simorini

Bioorg Med Chem· February 2016

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Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.
Silvia Salerno, Anna Maria Marini, Giacomo Fornaciari, Francesca Simorini, Concettina La Motta

Eur J Med Chem· October 2015

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Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.
Elisabetta Barresi, Agostino Bruno, Sabrina Taliani, Sandro Cosconati, Eleonora Da Pozzo, Francesca Simorini

J Med Chem· August 2015

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Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.
Stefania Sartini, Vito Coviello, Agostino Bruno, Valeria La Pietra, Luciana Marinelli, Francesca Simorini

J Med Chem· February 2014

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Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.
Sabrina Taliani, Isabella Pugliesi, Elisabetta Barresi, Silvia Salerno, Christophe Marchand, Francesca Simorini

J Med Chem· September 2013

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Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
Stefania Sartini, Sandro Cosconati, Luciana Marinelli, Elisabetta Barresi, Salvatore Di Maro, Francesca Simorini

J Med Chem· December 2012

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Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
Anna M Marini, Alfonso Maresca, Mayank Aggarwal, Elisabetta Orlandini, Susanna Nencetti, Francesca Simorini

J Med Chem· November 2012

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Medicinal chemistry of indolylglyoxylamide GABAA/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents.
Silvia Salerno, Federico Da Settimo, Sabrina Taliani, Francesca Simorini, Concettina La Motta

Curr Top Med Chem· June 2012

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Medicinal chemistry of indolylglyoxylamide TSPO high affinity ligands with anxiolytic-like effects.
Francesca Simorini, Anna Maria Marini, Sabrina Taliani, Concettina La Motta, Silvia Salerno

Curr Top Med Chem· June 2012

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3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
Sabrina Taliani, Isabella Pugliesi, Elisabetta Barresi, Francesca Simorini, Silvia Salerno

J Med Chem· February 2012

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Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
Barbara Cosimelli, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Federico Da Settimo

Eur J Med Chem· September 2011

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Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity.
Barbara Costa, Eleonora Da Pozzo, Beatrice Chelli, Nicola Simola, Micaela Morelli, Francesca Simorini

Psychoneuroendocrinology· May 2011

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Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
Sabrina Taliani, Concettina La Motta, Laura Mugnaini, Francesca Simorini, Silvia Salerno

J Med Chem· May 2010

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Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Sabrina Taliani, Eleonora Da Pozzo, Marusca Bellandi, Sara Bendinelli, Isabella Pugliesi, Francesca Simorini

J Med Chem· May 2010

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Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.
Lisa Dalla Via, Sebastiano Marciani Magno, Ornella Gia, Anna Maria Marini, Federico Da Settimo, Francesca Simorini

J Med Chem· September 2009

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Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Sabrina Taliani, Barbara Cosimelli, Federico Da Settimo, Anna Maria Marini, Concettina La Motta, Francesca Simorini

J Med Chem· June 2009

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Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.
Concettina La Motta, Stefania Sartini, Laura Mugnaini, Silvia Salerno, Francesca Simorini

J Med Chem· March 2009

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Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Federico Da Settimo, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Anna Maria Marini

J Med Chem· September 2008

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