Publications by authors named "Francesco Leva"

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Vincristine Beyond Mitosis: Uncovering a First Link to G-Quadruplex DNA in Cancer Cells.
Anna Di Porzio, Carolina Persico, Francesca Romano, Alessandra Barra, Immacolata Aiello, Francesco Saverio Di Leva

Int J Mol Sci· October 2025

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Design, synthesis and characterization of aryl bis-guanyl hydrazones as RNA binders of C9orf72 GC extended repeats.
Alice Maiocchi, Martina Pedrini, Veronica Ferrari, Agata Sofia Assunçao Carreira, Vincenzo Maria D'Amore, Francesco Saverio Di Leva

Eur J Med Chem· September 2025

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Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision Therapy.
Isidora Diakogiannaki, Vincenzo Maria D'Amore, Alessandra Affinito, Greta Donati, Elpidio Cinquegrana, Francesco Saverio Di Leva

J Chem Inf Model· June 2025

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Optimizing Body Composition During Weight Loss: The Role of Amino Acid Supplementation.
Daniele Cannavaro, Francesco Leva, Alfredo Caturano, Cesare Celeste Berra, Leonilde Bonfrate

Nutrients· June 2025

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Deepening bis-(thio)carbohydrazones conformational dynamics and hydrogen bond interactions in a non-protic solvent: DFT, molecular dynamics, NMR, and Raman investigations.
Federica Santoro, Vincenzo Maria D'Amore, Alessio Zavaroni, Isidora Diakogiannaki, Dominga Rogolino, Francesco Saverio Di Leva

J Chem Phys· March 2025

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Ex.50.T aptamer impairs tumor-stroma cross-talk in breast cancer by targeting gremlin-1.
Cristina Quintavalle, Francesco Ingenito, Giuseppina Roscigno, Birlipta Pattanayak, Carla Lucia Esposito, Francesco Saverio Di Leva

Cell Death Discov· March 2025

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Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands.
Beatrice Stefanie Ludwig, Nils Krautkremer, Stefano Tomassi, Salvatore Di Maro, Francesco Saverio Di Leva

J Med Chem· February 2025

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Design, Synthesis, and Anticancer Activity of Drug-like Iron Chelators/G-Quadruplex Binders as Synergic Dual Targeting Agents.
Marialuisa Piccolo, Camilla Russo, Valentina Arciuolo, Maria Grazia Ferraro, Vincenzo Abbate, Francesco Saverio Di Leva

J Med Chem· January 2025

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Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes myelination.
Antonella Damiana Recchia, Alessandra Dominicis, Vincenzo Maria D'Amore, Tommaso Fabiano, Aland Ibrahim Ahmed Al Jaf, Francesco Saverio Di Leva

Front Mol Neurosci· October 2024

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A combined approach of structure-based virtual screening and NMR to interrupt the PD-1/PD-L1 axis: Biphenyl-benzimidazole containing compounds as novel PD-L1 inhibitors.
Greta Donati, Monica Viviano, Vincenzo Maria D'Amore, Alessandra Cipriano, Isidora Diakogiannaki, Francesco Saverio Di Leva

Arch Pharm (Weinheim)· March 2024

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Paper-based electrochemical device for early detection of integrin αvβ6 expressing tumors.
Stefano Cinti, Stefano Tomassi, Chiara Ciardiello, Rossella Migliorino, Marinella Pirozzi, Francesco Saverio Di Leva

Commun Chem· March 2024

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Development and Nanoparticle-Mediated Delivery of Novel MDM2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in Colorectal Cancer Cells.
Francesco Merlino, Annalisa Pecoraro, Giuseppe Longobardi, Greta Donati, Francesco Saverio Di Leva

J Med Chem· February 2024

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Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists.
Camilla Russo, Pasquale Russomanno, Vincenzo Maria D'Amore, Antonella Ilenia Alfano, Federica Santoro, Francesco Saverio Di Leva

J Med Chem· February 2024

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Exploring the 1,3-benzoxazine chemotype for cannabinoid receptor 2 as a promising anti-cancer therapeutic.
Nicola Gambacorta, Valeria Gasperi, Tatiana Guzzo, Francesco Saverio Di Leva, Fulvio Ciriaco

Eur J Med Chem· November 2023

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Molecular View on the RGD Peptide Binding Mechanism: Implications for Integrin Activity and Selectivity Profiles.
Vincenzo Maria D'Amore, Greta Donati, Elena Lenci, Beatrice Stefanie Ludwig, Susanne Kossatz, Francesco Saverio Di Leva

J Chem Inf Model· October 2023

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Theoretical and experimental studies on the interaction of biphenyl ligands with human and murine PD-L1: Up-to-date clues for drug design.
Greta Donati, Vincenzo Maria D'Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Francesco Saverio Di Leva

Comput Struct Biotechnol J· June 2023

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Broad-spectrum coronavirus 3C-like protease peptidomimetic inhibitors effectively block SARS-CoV-2 replication in cells: Design, synthesis, biological evaluation, and X-ray structure determination.
Irina Stefanelli, Angela Corona, Carmen Cerchia, Emilia Cassese, Salvatore Improta, Francesco Saverio Di Leva

Eur J Med Chem· May 2023

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Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists.
Claudia Finamore, Carmen Festa, Bianca Fiorillo, Francesco Saverio Di Leva, Rosalinda Roselli

Molecules· March 2023

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The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JPCyV.
Maria Elena Marcocci, Bianka Gabriela Jackowska, Carla Prezioso, Virginia Protto, Marta De Angelis, Francesco Saverio Di Leva

Int J Mol Sci· June 2022

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Targeting SARS-CoV-2 Proteases and Polymerase for COVID-19 Treatment: State of the Art and Future Opportunities.
Rolando Cannalire, Carmen Cerchia, Andrea R Beccari, Francesco Saverio Di Leva, Vincenzo Summa

J Med Chem· February 2022

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Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand.
Stefano Tomassi, Vincenzo Maria D'Amore, Francesco Saverio Di Leva, Andrea Vannini, Giacomo Quilici

J Med Chem· May 2021

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The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins.
Beatrice Stefanie Ludwig, Stefano Tomassi, Salvatore Di Maro, Francesco Saverio Di Leva, Anke Benge

Biomaterials· April 2021

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Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences.
Stefano Tomassi, Anna Maria Trotta, Caterina Ieranò, Francesco Merlino, Anna Messere, Francesco Saverio Di Leva

Chemistry· August 2020

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Bioinformatics and Biosimulations as Toolbox for Peptides and Peptidomimetics Design: Where Are We?
Ilda D'Annessa, Francesco Saverio Di Leva, Anna La Teana, Ettore Novellino, Vittorio Limongelli

Front Mol Biosci· May 2020

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GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis.
Simona De Marino, Claudia Finamore, Michele Biagioli, Adriana Carino, Silvia Marchianò, Francesco Saverio Di Leva

ACS Med Chem Lett· May 2020

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