Publications by authors named "Fraser Wright"

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The promising potential of gene therapy for diabetes mellitus.
Stefan R Bornstein, J Fraser Wright, Charlotte Steenblock

Nat Rev Endocrinol· November 2024

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Erratum: AAV vector production: Troublesome host innate responses in another setting.
J Fraser Wright

Mol Ther Methods Clin Dev· September 2023

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Re-administration of AAV vectors by masking with host albumin: A Goldilocks hypothesis.
J Fraser Wright

Mol Ther· July 2023

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AAV vector production: Troublesome host innate responses in another setting.
J Fraser Wright

Mol Ther Methods Clin Dev· March 2023

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Design of experiments as a decision tool for cell therapy manufacturing.
Esmond Lee, Devin Shah, Matthew Porteus, J Fraser Wright, Rosa Bacchetta

Cytotherapy· June 2022

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AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicities.
J Fraser Wright

Mol Ther· June 2022

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Safety Assessment of AAV2-hGDNF Administered Via Intracerebral Injection in Rats for Treatment of Parkinson's Disease.
Pramod S Terse, Adrian P Kells, Patricia Noker, J Fraser Wright, Krystof S Bankiewicz

Int J Toxicol· January 2022

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Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes.
Bradley A Hamilton, J Fraser Wright

Front Immunol· October 2021

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The intersection of vector biology, gene therapy, and hemophilia.
Leszek Lisowski, Janice M Staber, J Fraser Wright, Leonard A Valentino

Res Pract Thromb Haemost· August 2021

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Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease.
Annalisa Lattanzi, Joab Camarena, Premanjali Lahiri, Helen Segal, Waracharee Srifa, J Fraser Wright

Sci Transl Med· June 2021

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Quality Control Testing, Characterization and Critical Quality Attributes of Adeno-Associated Virus Vectors Used for Human Gene Therapy.
J Fraser Wright

Biotechnol J· January 2021

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Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll.
J Fraser Wright

Mol Ther· August 2020

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Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates.
Benjamin J Samelson-Jones, Jonathan D Finn, Patricia Favaro, J Fraser Wright, Valder R Arruda

Mol Ther Methods Clin Dev· June 2020

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Codon Modification and PAMPs in Clinical AAV Vectors: The Tortoise or the Hare?
J Fraser Wright

Mol Ther· March 2020

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Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies.
Robert M Kotin, J Fraser Wright

Hum Gene Ther· December 2019

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Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials.
Albert M Maguire, Stephen Russell, Jennifer A Wellman, Daniel C Chung, Zi-Fan Yu, J Fraser Wright

Ophthalmology· September 2019

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Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial.
Frances H Priddy, David J M Lewis, Huub C Gelderblom, Hana Hassanin, Claire Streatfield, J Fraser Wright

Lancet HIV· April 2019

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Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.
Catherine Cukras, Henry E Wiley, Brett G Jeffrey, H Nida Sen, Amy Turriff, J Fraser Wright

Mol Ther· September 2018

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Relative survival of patients with lymphoma in Queensland according to histological subtype.
Fraser Wright, Greg Hapgood, Aravi Loganathan, Nathan Dunn, Shoni Philpot

Med J Aust· August 2018

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Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
Lindsey A George, Spencer K Sullivan, Adam Giermasz, John E J Rasko, Benjamin J Samelson-Jones, J Fraser Wright

N Engl J Med· December 2017

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Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial.
Stephen Russell, Jean Bennett, Jennifer A Wellman, Daniel C Chung, Zi-Fan Yu, J Fraser Wright

Lancet· August 2017

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Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial.
Jean Bennett, Jennifer Wellman, Kathleen A Marshall, Sarah McCague, Manzar Ashtari, J Fraser Wright

Lancet· August 2016

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Progress and challenges in viral vector manufacturing.
Johannes C M van der Loo, J Fraser Wright

Hum Mol Genet· April 2016

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Towards routine manufacturing of gene therapy drugs.
Otto-Wilhelm Merten, J Fraser Wright

Mol Ther Methods Clin Dev· April 2016

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Effects of FVIII immunity on hepatocyte and hematopoietic stem cell-directed gene therapy of murine hemophilia A.
Allison M Lytle, Harrison C Brown, Na Yoon Paik, Kristopher A Knight, J Fraser Wright

Mol Ther Methods Clin Dev· February 2016

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