Publications by authors named "Fred Wright"

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Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies.
Angela Bearth, Birgit Kopainsky, Lowenna B Jones, Gunn E Vist, Trine Husøy, Fred A Wright

Arch Toxicol· December 2025

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Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model.
Zhuolin Song, Volodymyr P Tryndyak, Rose A Willett, Igor P Pogribny, Ivan Rusyn, Fred A Wright

Toxicol Sci· November 2025

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Strain and Sex Variability in Liver, Kidney and Lung Levels of DNA Adducts EB-GII and -N7G-BD Following Inhalation Exposure to 1,3-Butadiene in Collaborative Cross Mice.
Erik Moran, Samantha Goodman, Fred A Wright, Richard Evans, Natalia Y Tretyakova

Toxics· October 2025

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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice.
Volodymyr P Tryndyak, Rose A Willett, Zhuolin Song, Kostiantyn Dreval, Jennifer M Hughes Hanks, Fred A Wright

Toxicol Appl Pharmacol· September 2025

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Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits.
Kevin W Currin, Hannah J Perrin, Gautam K Pandey, Abdalla A Alkhawaja, Swarooparani Vadlamudi, Fred A Wright

Genome Res· July 2025

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An approach to uncover significant direct and mediated relationships in multi-dimensional new approach methods (NAMs) data: A case study of hazard evaluation of petroleum UVCBs.
Yi-Hui Zhou, Paul J Gallins, Ivan Rusyn, Fred A Wright

Sci Total Environ· July 2025

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A workflow for human health hazard evaluation using transcriptomic data and Key Characteristics-based gene sets.
Han-Hsuan D Tsai, King D Oware, Fred A Wright, Weihsueh A Chiu, Ivan Rusyn

Toxicol Sci· June 2025

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HAP-SAMPLE2: data-based resampling for association studies with admixture.
George Sun, Bryan W Ting, Fred A Wright, Yi-Hui Zhou

Bioinformatics· June 2025

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A systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency.
Hannah M Roe, Han-Hsaun D Tsai, Nicholas Ball, Fred A Wright, Weihsueh A Chiu

ALTEX· April 2025

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Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population.
Danila Cuomo, Zhuolin Song, Megan Nitcher, Rachel Lynch, Estefania Barba, Fred A Wright

Toxicol Sci· April 2025

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Asian diversity in human immune cells.
Kian Hong Kock, Le Min Tan, Kyung Yeon Han, Yoshinari Ando, Damita Jevapatarakul, Fred A Wright

Cell· April 2025

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Zebrafish Cyp1b1 knockout alters eye and brain metabolomic profiles, affecting ocular and neurobehavioral function.
Dante M Perone, Andrew J Annalora, Jared V Goldstone, Allison N Dickey, Matthew C Salanga, Fred A Wright

Toxicol Appl Pharmacol· March 2025

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Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis.
Jaclyn R Stonebraker, Rhonda G Pace, Paul J Gallins, Hong Dang, Melis A Aksit, Fred A Wright

Hepatology· November 2024

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Two-Stage Machine Learning-Based Approach to Predict Points of Departure for Human Noncancer and Developmental/Reproductive Effects.
Jacob Kvasnicka, Nicolò Aurisano, Kerstin von Borries, En-Hsuan Lu, Peter Fantke, Fred A Wright

Environ Sci Technol· September 2024

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Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits.
K Alaine Broadaway, Sarah M Brotman, Jonathan D Rosen, Kevin W Currin, Abdalla A Alkhawaja, Fred Wright

Am J Hum Genet· September 2024

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Characterizing PFAS hazards and risks: a human population-based in vitro cardiotoxicity assessment strategy.
Lucie C Ford, Hsing-Chieh Lin, Yi-Hui Zhou, Fred A Wright, Vijay K Gombar

Hum Genomics· September 2024

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Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology.
Gro H Mathisen, Angela Bearth, Lowenna B Jones, Sebastian Hoffmann, Gunn E Vist, Fred Wright

Arch Toxicol· August 2024

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Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human-Induced Pluripotent Stem-Cell-Derived Cardiomyocytes.
Han-Hsuan D Tsai, Lucie C Ford, Sarah D Burnett, Allison N Dickey, Fred A Wright

Chem Res Toxicol· August 2024

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A Systematic Analysis of Read-Across Adaptations in Testing Proposal Evaluations by the European Chemicals Agency.
Hannah M Roe, Han-Hsuan D Tsai, Nicholas Ball, Fred A Wright, Weihsueh A Chiu

bioRxiv· August 2024

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Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes.
Han-Hsuan D Tsai, Lucie C Ford, Zunwei Chen, Allison N Dickey, Fred A Wright

ALTEX· July 2024

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Control of false discoveries in grouped hypothesis testing for eQTL data.
Pratyaydipta Rudra, Yi-Hui Zhou, Andrew Nobel, Fred A Wright

BMC Bioinformatics· April 2024

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Hazard and risk characterization of 56 structurally diverse PFAS using a targeted battery of broad coverage assays using six human cell types.
Lucie C Ford, Hsing-Chieh Lin, Han-Hsuan D Tsai, Yi-Hui Zhou, Fred A Wright

Toxicology· March 2024

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Ten years of using key characteristics of human carcinogens to organize and evaluate mechanistic evidence in IARC Monographs on the identification of carcinogenic hazards to humans: Patterns and associations.
Ivan Rusyn, Fred A Wright

Toxicol Sci· February 2024

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Application of Ion Mobility Spectrometry-Mass Spectrometry for Compositional Characterization and Fingerprinting of a Library of Diverse Crude Oil Samples.
Alexandra C Cordova, James N Dodds, Han-Hsuan D Tsai, Dillon T Lloyd, Alina T Roman-Hubers, Fred A Wright

Environ Toxicol Chem· November 2023

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Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity.
Courtney Sakolish, Haley L Moyer, Han-Hsuan D Tsai, Lucie C Ford, Allison N Dickey, Fred A Wright

Toxicol Sci· October 2023

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