Publications by authors named "Gabriel Birkus"

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Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: Structural basis of their function.
Martin Klima, Milan Dejmek, Vojtech Duchoslav, Andrea Eisenreichova, Michal Sala

Structure· April 2024

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Synthesis of Original Cyclic Dinucleotide Analogues Using the Sulfo-click Reaction.
Romain Amador, Jean-Jacques Vasseur, Gabriel Birkuš, Emmanuelle Bignon, Antonio Monari

Org Lett· February 2024

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Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Milan Dejmek, Andrea Brazdova, Tomáš Otava, Marketa Pimkova Polidarova, Martin Klíma

Eur J Med Chem· November 2023

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Synthetic Stimulator of Interferon Genes (STING) Agonists Induce a Cytokine-Mediated Anti-Hepatitis B Virus Response in Nonparenchymal Liver Cells.
Marketa Pimkova Polidarova, Lenka Vanekova, Petra Brehova, Milan Dejmek, Zdenek Vavrina, Gabriel Birkus

ACS Infect Dis· January 2023

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus.
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Gabriel Birkus

PLoS One· December 2022

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Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Zdeněk Vavřina, Pavla Perlíková, Nemanja Milisavljević, Florian Chevrier, Miroslav Smola

J Med Chem· October 2022

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Multiparametric Flow Cytometry-Based Immunophenotyping of Mouse Liver Immune Cells.
Lenka Vanekova, Marketa Pimkova Polidarova, Vaclav Veverka, Gabriel Birkus, Andrea Brazdova

Methods Protoc· September 2022

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Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential.
Milan Dejmek, Michal Šála, Andrea Brazdova, Lenka Vanekova, Miroslav Smola

Structure· August 2022

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STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis.
Marketa Pimkova Polidarova, Petra Brehova, Milan Dejmek, Gabriel Birkus, Andrea Brazdova

ACS Infect Dis· March 2022

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Corrigendum to "5'-Phosphonate modified oligoadenylates as potent activators of human RNase L" [Bioorg. Med. Chem. 56 (2022) 116632].
Tomáš Lášek, Magdalena Petrová, Ivana Košiová, Ondřej Šimák, Miloš Buděšínský

Bioorg Med Chem· March 2022

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5'-Phosphonate modified oligoadenylates as potent activators of human RNase L.
Tomáš Lášek, Magdalena Petrová, Ivana Košiová, Ondřej Šimák, Miloš Buděšínský

Bioorg Med Chem· February 2022

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Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Barbora Novotná, Lucie Holá, Monika Staś, Ondrej Gutten, Miroslav Smola

Biochemistry· December 2021

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Synthesis of phosphonate derivatives of 2'-deoxy-2'-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides.
Tomáš Lášek, Juraj Dobiáš, Miloš Buděšínský, Jaroslav Kozák, Barbora Lapuníková

Tetrahedron· June 2021

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Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Markéta Pimková Polidarová, Petra Břehová, Martin Maxmilian Kaiser, Miroslav Smola, Martin Dračínský

J Med Chem· June 2021

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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein.
Miroslav Smola, Ondrej Gutten, Milan Dejmek, Milan Kožíšek, Thomas Evangelidis

Angew Chem Int Ed Engl· April 2021

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Protein-Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory.
Zdeněk Vavřina, Ondrej Gutten, Miroslav Smola, Martin Zavřel, Zahra Aliakbar Tehrani

Biochemistry· March 2021

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Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Barbora Novotná, Lenka Vaneková, Martin Zavřel, Miloš Buděšínský, Milan Dejmek

J Med Chem· December 2019

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Anti-HBV activity of retinoid drugs in vitro versus in vivo.
Gabriel Birkus, Chelsea Snyder, Robert Jordan, Tetsuya Kobayashi, Ryan Dick

Antiviral Res· September 2019

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No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides.
Miroslav Smola, Gabriel Birkus, Evzen Boura

Acta Crystallogr F Struct Biol Commun· September 2019

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Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment.
Joy Y Feng, Ting Wang, Yeojin Park, Darius Babusis, Gabriel Birkus

Antimicrob Agents Chemother· August 2018

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.
Weimei Xing, Ona Barauskas, Thorsten Kirschberg, Anita Niedziela-Majka, Michael Clarke, Gabriel Birkus

PLoS One· October 2017

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs.
Ona Barauskas, Weimei Xing, Esmeralda Aguayo, Madeleine Willkom, Annapurna Sapre, Gabriel Birkus

PLoS One· October 2017

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Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Thorsten A Kirschberg, Sammy Metobo, Michael O Clarke, Vangelis Aktoudianakis, Darius Babusis, Gabriel Birkus

Bioorg Med Chem Lett· April 2017

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Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Ivana Mejdrová, Dominika Chalupská, Pavla Plačková, Christin Müller, Michal Šála, Gabriel Birkus

J Med Chem· January 2017

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Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors.
Michal Šála, Martin Kögler, Pavla Plačková, Ivana Mejdrová, Hubert Hřebabecký, Gabriel Birkus

Bioorg Med Chem Lett· June 2016

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